Last update 10 May 2025

JTT-251

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
JTT 251
Target
PDHK
Action
inhibitors
Mechanism
PDHK inhibitors(Pyruvate dehydrogenase kinase inhibitors)
Therapeutic Areas
Respiratory DiseasesOther Diseases
Active Indication-
Inactive Indication
Pulmonary Arterial Hypertension
Originator Organization
Japan Tobacco (Hong Kong) Ltd.
Active Organization-
Inactive Organization
Akros Pharma, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC26H30F3N3O5
InChIKeyWTPZYIZNHQOCOQ-VQIWEWKSSA-N
CAS Registry1627957-26-9

Related

3
Clinical Trials associated with JTT-251
PER-053-18
/ SuspendedPhase 2
A PHASE 2, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF JTT 251 ADMINISTERED FOR 24 WEEKS TO PARTICIPANTS WITH PULMONARY ARTERIAL HYPERTENSION (RELIEF–PAH)
NCT03789643
/ WithdrawnPhase 2
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JTT-251 Administered for 24 Weeks to Participants With Pulmonary Arterial Hypertension (RELIEF-PAH)
EUCTR2017-005093-19-DK
/ Not yet recruitingPhase 2
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JTT-251 Administered for 24 Weeks to Participants with Heart Failure with Reduced Ejection Fraction - BEAT-CHF
100 Clinical Results associated with JTT-251
Login to view more data
100 Translational Medicine associated with JTT-251
Login to view more data
100 Patents (Medical) associated with JTT-251
Login to view more data
100 Deals associated with JTT-251
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Arterial HypertensionPhase 2-
Akros Pharma, Inc.
01 Mar 2019
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free