Last update 14 Jun 2025

IBR854

Overview

Basic Info

Drug Type
CAR-NK
Synonyms
CAR-raNK, Conjugated Antibody Redirecting ready-to-use allogeneic NK cells, IBR 854
+ [2]
Target
5T4
Action
modulators
Mechanism
5T4 modulators(Trophoblast glycoprotein modulators), Gene transference(Gene transference), Natural killer cell replacements
Therapeutic Areas
NeoplasmsDigestive System DisordersUrogenital Diseases
Active Indication
Liver CancerAdvanced Renal Cell Carcinoma
Inactive Indication-
Originator Organization
Yingbairui (Hangzhou) Biomedical Co., Ltd.Yingbairui (Hangzhou) Biomedical Co., Ltd.
Active Organization
Yingbairui (Hangzhou) Biomedical Co., Ltd.Yingbairui (Hangzhou) Biomedical Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with IBR854
NCT06001684
/ RecruitingPhase 1
A Phase I Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of IBR854 Cell Injection in Patients With Unresectable Locally Advanced Or Metastatic Solid Tumors
NCT05137275
/ Unknown statusEarly Phase 1IIT
Dose Escalation and Extension Study to Evaluate the Safety, Tolerability, and Initial Efficacy of Anti-5T4 CAR-raNK Cell Therapy in Locally Advanced or Metastatic Solid Tumors
100 Clinical Results associated with IBR854
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100 Translational Medicine associated with IBR854
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100 Patents (Medical) associated with IBR854
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100 Deals associated with IBR854
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Liver CancerPhase 1
China
Yingbairui (Hangzhou) Biomedical Co., Ltd.Yingbairui (Hangzhou) Biomedical Co., Ltd.
31 Aug 2023
Advanced Renal Cell CarcinomaIND Approval
China
Yingbairui (Hangzhou) Biomedical Co., Ltd.Yingbairui (Hangzhou) Biomedical Co., Ltd.
18 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Clinical Trial

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Approval

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Regulation

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