Last update 21 Nov 2024

Acepromazine

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-[10-(3-dimethylamino-propyl)-10H-phenothiazin-2-yl]-ethanone, 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone, 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone

+ [5]

Target

DRDs

Mechanism

DRDs antagonists(Dopamine receptors antagonists)

Therapeutic Areas

Other Diseases

Active Indication

Behavioural disorders

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure

Molecular FormulaC19H22N2OS

InChIKeyNOSIYYJFMPDDSA-UHFFFAOYSA-N

CAS Registry61-00-7

100 Clinical Results associated with Acepromazine

100 Translational Medicine associated with Acepromazine

100 Patents (Medical) associated with Acepromazine

1,258

Literatures (Medical) associated with Acepromazine

01 Dec 2024·Veterinary Research Communications

Influence of gabapentin on the degree of sedation, physiological variables and propofol dosage in cats premedicated with acepromazine and methadone: a randomized, prospective, blinded, clinical study

Article

Author: de Almeida Filho, Fábio Trindade Dutra ; Ferronatto, João Victor Barbieri ; Correia, Bárbara Silva ; Cardozo, Haiumy Garcia ; Monteiro, Eduardo Raposo ; Zardo, Izadora Loeff

This study evaluated the influence of gabapentin on sedation, propofol dosage, and physiological variables in cats premedicated with acepromazine and methadone. Thirty-four cats were randomly assigned to receive 100 mg of oral gabapentin (Gabapentin group) or placebo (Control group) 100 min before intramuscular premedication with acepromazine (0.05 mg/kg) plus methadone (0.3 mg/kg). Variables recorded included sedation, using the Dynamic Interactive Visual Analog Scale (DIVAS, range 0-100 mm) and a Numeric Descriptive Scale (NDS, range 0-14), heart rate, respiratory rate and Doppler systolic arterial pressure (SAP). All variables were measured before (T0), 100 min after administration of gabapentin or placebo (T1), and 30 min after premedication (T2). Physiological variables were also recorded after anesthetic induction with propofol (T3). At T2, NDS scores were higher in Gabapentin than the Control group [median (interquartile range): 4 (2-5) versus 2 (1-4), p = 0.028], whereas DIVAS scores were not significantly different [Control: 9 (4-13); Gabapentin: 12 (5-32)]. Despite the significant difference between groups in NDS scores, overall sedation scores were mild at T1 and T2 regardless of gabapentin administration. The propofol dosage did not differ between groups. The most concerning adverse effect was arterial hypotension (SAP < 90 mmHg), recorded only at T3 in 71% of cats in the Control group and 100% in the Gabapentin group, without significant difference between groups. Administration of gabapentin before premedication with acepromazine and methadone in healthy cats did not result in a clinically significant influence on sedation levels, physiological variables, or propofol dosage required for anesthesia induction.

01 Nov 2024·American Journal of Veterinary Research

Transpulmonary cardiac output with room temperature saline is accurate and tracks directional changes in anesthetized dogs

Article

Author: Cannarozzo, Cheyenne J. ; Martin-Flores, Manuel ; Araos, Joaquin

AbstractOBJECTIVETo assess the performance of transpulmonary thermodilution (TPTD) using room-temperature saline (CORT) and waveform-derived continuous CO (CCO) compared with TPTD using iced saline (COICED) as the indicator for measurements of CO in isoflurane-anesthetized dogs.METHODS8 Beagles aged 1 to 2 years (7.4 to 11.2 kg) were enrolled in this experimental study from March 21 to 31, 2023. Dogs were anesthetized with 0.01 mg/kg acepromazine, 5 to 6 mg/kg propofol, and isoflurane and were mechanically ventilated. Dogs were instrumented with a central venous catheter and a femoral arterial catheter equipped with a thermistor. The COICED, CORT, and pulse wave-derived CCO values were obtained at baseline, during infusions of phenylephrine and norepinephrine, and during blood withdrawal and replacement. Data were analyzed with a mixed effect model, Bland-Altman plots, and concordance. Percent error was calculated. P < .05 was used for significance.RESULTSData were collected from 8 dogs. Significant effects of time and the interaction of time and method were found. Bland-Altman plots showed negligible bias with limits of agreement between −0.35 and 0.25 L/min for CORT versus COICED and −1.23 and 1.15 L/min for CCO versus COICED. Percent errors were 17.7% and 66.6%, respectively. In the 4-quadrant plots, the concordance rate was 95% and 68% for measurements obtained with CORT and for CCO, respectively.CONCLUSIONSTranspulmonary thermodilution using room temperature saline was accurate and able to track changes in CO. Continuous CO had a large percent error and low tracking ability.CLINICAL RELEVANCETranspulmonary thermodilution using room temperature saline is reliable for monitoring CO and obviates the need for iced preparations in clinical scenarios.

01 Nov 2024·Veterinary Medicine and Science

Effects of acepromazine, xylazine and propofol on spinal reflexes in healthy dogs

Article

Author: Kazemi Mehrjerdi, Hossein ; Sarchahi, Ali Asghar ; Sheykhbahaedinzade, Ali

AbstractBackgroundIn the neurological examination, it is crucial to identify the possible location of the lesion in order to determine the appropriate treatment process. In aggressive animals, chemical restraint may be necessary due to their non‐cooperative behaviour. However, sedatives may distort the results of examinations. Therefore, a drug should be found that has minimal impact on the examination results.ObjectivesTo investigate the effects of acepromazine, xylazine, and propofol on spinal reflexes in healthy dogs.MethodsIn a randomized, blinded study, ten native adult mixed‐breed dogs were participated in three groups with a 1‐week washout period between each group. Before performing each step, the spinal reflexes were evaluated. Then, in the first group, acepromazine (0.05 mg/kg, IM), in the second group, xylazine (1 mg/kg, IM), and in the third group, propofol (3 mg/kg, IV for initial bolus and 0.1 mg/kg/min for maintenance) were injected for sedation. The spinal reflexes were reevaluated at maximum sedation and at 15, 30, and 45 min thereafter.ResultsAcepromazine increased the patellar reflex and decreased the panniculus reflex. Xylazine increased the cranial tibial reflex and decreased the panniculus reflex, while propofol decreased the withdrawal, and extensor carpi radialis reflexes, and suppressed the palpebral and gag reflexes.ConclusionsThe drugs used in the present study did not have a significant impact on the most important reflexes evaluated in neurological examinations. Among the drugs, acepromazine has the least effects compared to other drugs, making it a suitable choice for sedation.

100 Deals associated with Acepromazine

External Link

KEGG	Wiki	ATC	Drug Bank
D07065	Acepromazine	N05AA04	DB01614

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Behavioural disorders	-	-	-

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Acepromazine

Overview

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Structure

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External Link

R&D Status

Clinical Result

Translational Medicine

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Core Patent

Clinical Trial

Approval

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