NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), Sodium channels blockers, VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization

China Resources Double-Crane Pharmaceutical Co., Ltd.

Active Organization

China Resources Double-Crane Pharmaceutical Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

China (04 Aug 2015),

Hypertension

Regulation-

Structure/Sequence

Molecular FormulaC7H8ClN3O4S2

InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N

CAS Registry58-93-5

View All Structures (4)

Clinical Trials associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

CTR20140795

/ Active, not recruitingNot Applicable

复方利血平氨苯蝶啶胶囊人体生物等效性试验

[Translation] Bioequivalence study of compound reserpine and triamterene capsules in human body

本试验的目的是选择中国健康受试者，以北京星昊医药股份有限公司提供的复方利血平氨苯蝶啶胶囊为受试制剂，按有关BE试验的规定，与国内上市的北京双鹤药业股份有限公司生产的复方利血平氨苯蝶啶片（商品名：0号，参比制剂）进行人体相对生物利用度与生物等效性试验，计算受试制剂的相对生物利用度，比较两种制剂的生物等效性。

[Translation]

The purpose of this study was to select healthy Chinese subjects, use the compound reserpine and triamterene capsules provided by Beijing Xinghao Pharmaceutical Co., Ltd. as the test preparation, and conduct human relative bioavailability and bioequivalence tests on the compound reserpine and triamterene tablets (trade name: No. 0, reference preparation) produced by Beijing Shuanghe Pharmaceutical Co., Ltd. on the domestic market in accordance with the relevant BE test regulations, calculate the relative bioavailability of the test preparation, and compare the bioequivalence of the two preparations.

Start Date08 Apr 2015

Sponsor / Collaborator

Beijing Sunho Pharmaceutical Co., Ltd.

100 Clinical Results associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

100 Translational Medicine associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

100 Patents (Medical) associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

Literatures (Medical) associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

Collegium Antropologicum

An analysis of the pollution problem in Slavonski Brod (eastern Croatia)

Author: Brana, Josip ; Roland, Danijela ; Puntaric, Dinko ; Gvozdic, Vlatka ; Malatesti, Nela ; Vidosavljevic, Domagoj

H₂S, PM_2.5, O₃, NO₂, SO₂ and meteorol. parameters such as temperature, relative humidity, precipitation, wind speed and wind direction were measured simultaneously in an eastern Croatian town called Slavonski Brod during the season winter/spring 2010.Emissions from the nearby cross-border (Bosnia and Herzegovina) oil refinery were identified as sources of temporary elevated concentrations of H₂S.The maximum daily averages of PM_2.5 concentrations during the winter period were as high as 240 μg m_-3 which is a value 10 times greater than the threshold prescribed by the World Health Organization.It is considered that the heating season, dense traffic, intense industrial activities and temperature inversion during stable weather conditions are prevailing contributors to higher winter concentrations of PM_2.5.The results of the principal component anal. technique (PCA) have shown that lower air temperature, lower wind speed and higher relative humidity play a significant role in the winter pollution episodes.From a public health point of view, implementation of measures aimed at reducing the levels of H₂S and PM_2.5 should be considered.

Journal of Environmental Sciences (Beijing, China)

Treating both wastewater and excess sludge with an innovative process

Author: Wang, Lin ; Jiang, Yi-feng ; Wang, Bao-zhen ; He, Sheng-bing

The innovative process consists of biol. unit for wastewater treatment and ozonation unit for excess sludge treatment.An aerobic membrane bioreactor (MBR) was used to remove organics and N, and an anaerobic reactor was added to the biol. unit for the release of P contained at aerobic sludge to enhance the removal of P.For the excess sludge produced in the MBR, which was fed to ozone contact column and reacted with ozone, then the ozonated sludge was returned to the MBR for further biol. treatment.This process could remove organics, N, and P efficiently, and the removals for COD, NH₃-N, TN and TP were 93.17, 97.57, 82.77, and 79.5%, resp.Batch test indicated that the specific nitrification rate and specific denitrification rate of the MBR were 1.03 mg NH₃-N/(g MLSS·h) and 0.56 mg NO_x-N/(g MLSS·h), and denitrification seems to be the rate-limiting step.Under the test conditions, the sludge concentration in the MBR was kept at 5000-6000 mg/L, and the wasted sludge was ozonated at an ozone dosage of 0.10 kg O₃/kg SS.During the exptl. period of 2 mo, no excess sludge was wasted, and a zero withdrawal of excess sludge was implemented.

Guangpuxue Yu Guangpu Fenxi

Study on removing the lamp spectrum structure in differential optical absorption spectroscopy

Author: Qu, Xiao-ying ; Li, Yu-jin

Differential optical absorption spectroscopy (DOAS) technique has been used to measure trace gases in the atm. by their strongly structured absorption of radiation in the UV and visible spectral range, and nowadays this technique has been widely utilized to measure.trace polluted gases in the atm. e.g. SO₂, NO₂, O₃, HCHO, etc.People home and abroad generally employ two ways to handle this problem, one is segmenting band retrieving method, another is remedial retrieveing method.In the present paper, a new retrieving method to deal with this trouble is introduced.The authors used moving-window average smoothing method to obtain the slow part of the absorption spectra of atm., then achieved the lamp (xenon lamp in the paper) spectrum structure in the measured band of the absorption spectra of atm.The authors analyzed and retrieved the measured spectrum of the atm., and the result is better than the forenamed ways.χ² Of residuum was 2.995 × 10^-4, and this method was proved to be able to avoid shortcoming of choosing narrow band and disadvantage of discovering the new component of atm. in retrieving the concentration of air pollutants and measuring the air pollutants.

100 Deals associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

External Link

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Indication	Country/Location	Organization	Date
Hypertension	China	China Resources Double-Crane Pharmaceutical Co., Ltd.	04 Aug 2015

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