Delving into the Latest Updates on NBM-BMX softgel capsules with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

NBM BMX softgel capsules, NBM-BMX

+ [1]

Target

HDAC8

Mechanism

HDAC8 inhibitors(Histone deacetylase 8 inhibitors)

Therapeutic Areas

NeoplasmsNervous System DiseasesOther Diseases

Active Indication

NeoplasmsAdvanced Malignant Solid NeoplasmGlioblastoma+ [1]

Inactive Indication

Advanced cancer

Originator Organization

NatureWise Biotech & Medicals Corp.

Active Organization

NatureWise Biotech & Medicals Corp.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC23H27NO5

InChIKeySOWOYQPLOHLYEY-NTEUORMPSA-N

CAS Registry1246952-34-0

NBM-BMX is an orally available new chemical entity to inhibit histone deacetylases 8 (HDAC8) activity specifically, being developed as a potential anti-cancer therapeutic by NatureWise. This study aims to evaluate the safety, pharmacokinetics, and preliminary efficacy of NBM-BMX as monotherapy in subjects with advanced solid tumors or combination with the standard of care treatment in subjects with newly diagnosed glioblastoma.

Start Date11 Aug 2023

Sponsor / Collaborator-

IRCT20180610040037N5

/ RecruitingPhase 3IIT

Examining the Effectiveness and Side Effects of Softgel-Encapsulated IMOD in Individuals Living with HIV

Start Date23 Jul 2023

Sponsor / Collaborator

Tehran University of Medical Sciences

NCT03808870

/ CompletedPhase 1

A Phase 1, Open-label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Efficacy of NBM-BMX in Asian Subjects With Advanced Solid Tumors

NBM-BMX is an orally available new chemical entity to inhibit HDAC8 activity specifically, being developed as a potential anti-cancer therapeutic by NatureWise. The objectives of this study are to evaluate the safety, pharmacokinetics, and preliminary efficacy of NBM-BMX as monotherapy in subjects with advanced solid tumors (Arm A) or in combination with the standard of care treatment (i.e., concomitant RT/TMZ followed by adjuvant TMZ) in subjects with newly diagnosed glioblastoma (Arm B).

Start Date28 Dec 2018

Sponsor / Collaborator

NatureWise Biotech & Medicals Corp.

100 Clinical Results associated with NBM-BMX softgel capsules

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100 Translational Medicine associated with NBM-BMX softgel capsules

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100 Patents (Medical) associated with NBM-BMX softgel capsules

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106

Literatures (Medical) associated with NBM-BMX softgel capsules

06 Jun 2024·International Journal of Phytoremediation

Effective removal of malachite green oxalate from aqueous solution using Newbouldia laevis husk/MWCNTs nanocomposite: equilibrium, kinetics, and thermodynamics

Article

Author: Amaku, Friday James ; Taziwa, Raymond

The discharge of colored effluent into water bodies is a big concern; hence, the current work was designed to fabricate a superior nanocomposite (NBM) using the Newbouldia laevis husk (NB) and functionalized multiwalled carbon nanotubes (f-MWCNTs) for the adsorption of malachite green oxalate (MGO). Brunauer-Emmett-Teller (BET) surface analysis was used to assess the specific surface area of NB (0.7699 m² g^-1) and NBM (94.006 m² g^-1). Fourier transform infrared spectroscopy (FTIR) was employed to determine the chemical moieties on the surface of the adsorbent. Field emission scanning electron microscopy (FESEM) and thermogravimetric analysis (TGA) were used to analyze the surface morphology and the thermal behavior of the adsorbents. Essential factors of the adsorption process were investigated, and it was revealed that pH 6.0, adsorbent dose of 0.05 g, contact time 80 min, concentration of 100 mg dm^-3 and maximum adsorption capacity of 35.78 mg g^-1 (NB) and 69.97 mg g^-1 (NBM) were the optimal parameters. The NB and NBM adsorption processes followed a pseudo-first-order kinetic model. The exothermic and endothermic adsorptive processes were noticed to be the best descriptions of MGO elimination by NB and NBM, respectively. The uptake of MGO by NB and NBM was best described by models of Freundlich and Langmuir isotherms. Besides, NBM demonstrated uptake efficiency that is >80% after the fourth adsorption/desorption cycle. As a result, NBM has a wide range of possible uses in environmental remediation.

01 Apr 2024·World Neurosurgery

Deep Brain Stimulation as an Emerging Therapy for Cognitive Decline in Alzheimer Disease: Systematic Review of Evidence and Current Targets

Review

Author: Lopez, Alexander M ; Wong, Joey ; Paff, Michelle R ; Andalib, Saman ; Brown, Nolan J ; Dutta, Rajeev R ; Oh, Michael Y ; Solomon, Sean S ; Hsu, Frank P ; Picton, Bryce

OBJECTIVEWith no cure for Alzheimer disease (AD), current efforts involve therapeutics that prevent further cognitive impairment. Deep brain stimulation (DBS) has been studied for its potential to mitigate AD symptoms. This systematic review investigates the efficacy of current and previous targets for their ability to slow cognitive decline in treating AD.METHODSA systematic review of the literature was performed through a search of the PubMed, Scopus, and Web of Science databases. Human studies between 1994 and 2023 were included. Sample size, cognitive outcomes, and complications were recorded for each study.RESULTSFourteen human studies were included: 7 studies with 6 distinct cohorts (n = 56) targeted the fornix, 6 studies with 3 distinct cohorts (n = 17) targeted the nucleus basalis of Meynert (NBM), and 1 study (n = 3) investigated DBS of the ventral striatum (VS). The Alzheimer's Disease Assessment Scale-Cognitive Subscale, Mini-Mental State Examination, and Clinical Dementia Rating Scale Sum of Boxes were used as the primary outcomes. In 5 of 6 cohorts where DBS targeted the fornix, cognitive decline was slowed based on the Alzheimer's Disease Assessment Scale-Cognitive Subscale or Mini-Mental State Examination scores. In 2 of 3 NBM cohorts, a similar reduction was reported. When DBS targeted the VS, the patients' Clinical Dementia Rating Scale Sum of Boxes scores indicated a slowed decline.CONCLUSIONSThis review summarizes current evidence and addresses variability in study designs regarding the therapeutic benefit of DBS of the fornix, NBM, and VS. Because of varying study parameters, varying outcome measures, varying study durations, and limited cohort sizes, definitive conclusions regarding the utility of DBS for AD cannot be made. Further investigation is needed to determine the safety and efficacy of DBS for AD.

01 Aug 2023·Journal of Environmental Management

Revealing the mechanism of novel nitrogen-doped biochar supported magnetite (NBM) enhancing anaerobic digestion of waste-activated sludge by sludge characteristics

Article

Author: Zhang, Pengfei ; Zou, Xiang ; He, Junguo ; Cai, Qiupeng ; Zhong, Yijie ; Duan, Shengye ; Pan, Xinlei ; Zhang, Jie

Anaerobic digestion (AD) is a promising technology in waste treatment and energy recovery. However, it suffers from long retention time and low biogas yield. In this study, novel nitrogen-doped biochar supported magnetite (NBM) was synthesized and applied to enhance the AD of waste-activated sludge. Results showed that NBM increased cumulative methane production and SCOD removal efficiency by up to 1.75 times and 15% respectively at 5 g/L compared with the blank. NBM enhanced both hydrolysis and methanogenesis process during AD and the activities of α-glucosidase, protease, coenzyme F₄₂₀ and electron transport system were increased by 19%, 163%, 104% and 160% respectively at 5 g/L NBM compared with the blank. NBM also facilitated the secretion of conductive protein in extracellular polymeric substances as well as the formation of conductive pili, leading to 3.18-7.59 times higher sludge electrical conductivity. Microbial community analysis revealed that bacteria Clostridia and archaea Methanosarcina and Methanosaeta were enriched by the addition of NBM, and direct interspecies electron transfer might be promoted between them. This study provides a practical reference for future material synthesis and its application.

100 Deals associated with NBM-BMX softgel capsules

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Malignant Solid Neoplasm	Phase 2	TW	-	11 Aug 2023
Glioblastoma	Phase 2	TW	-	11 Aug 2023
Neoplasms	Phase 2	CN	NatureWise Biotech & Medicals Corp.	24 Aug 2022
Alzheimer Disease	Phase 1	CN	NatureWise Biotech & Medicals Corp.	24 Aug 2022
Advanced cancer	Preclinical	US	NatureWise Biotech & Medicals Corp.	16 Oct 2018