Last update 04 Nov 2025

SNC-109

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
SNC 109, SNC109
Target
EGFRvIII x IL-13Rα2
Action
antagonists, inhibitors
Mechanism
EGFRvIII antagonists(Epidermal growth factor receptor variant III antagonists), IL-13Rα2 inhibitors(Interleukin-13 receptor subunit alpha-2 inhibitors), Immunologic cytotoxicity
Therapeutic Areas
NeoplasmsNervous System DiseasesOther Diseases
Active Indication
Glioblastoma MultiformeRecurrent Glioblastoma
Inactive Indication-
Originator Organization
Shanghai Simnova Biotechnology Co.,Ltd.
Active Organization
Shanghai Simnova Biotechnology Co.,Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Related

2
Clinical Trials associated with SNC-109
NCT06616727
/ Enrolling by invitationPhase 1
A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of SNC109 in Patients With Recurrent Glioblastoma
NCT05868083
/ Unknown statusPhase 1
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of SNC-109 CAR-T Cell Therapy in Subjects With Recurrent Glioblastoma
100 Clinical Results associated with SNC-109
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100 Translational Medicine associated with SNC-109
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100 Patents (Medical) associated with SNC-109
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100 Deals associated with SNC-109
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 1
China
Shanghai Simnova Biotechnology Co.,Ltd.
26 Dec 2023
Recurrent GlioblastomaPhase 1
China
Shanghai Simnova Biotechnology Co.,Ltd.
24 Jun 2022
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Clinical Result

Indication
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Evaluation
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Clinical Trial

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Approval

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Regulation

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