The chemodivergent property of dimethyl sulfoxide (DMSO) along with 1,2-dichloroethane (DCE) was exploited for the incorporation of a methylene group to form diarylmethanes through a dearomatization/rearomatization process. Methyl(methylene)sulfonium ions (CH₂=S⁺-Me) were generated by simple heating of commonly used solvents such as DMSO and DCE. These ions were subsequently trapped by electron-rich arenes and heteroarenes, resulting in the synthesis of both symmetrical and unsymmetrical diarylmethanes. This protocol was further extended to access N-methylenamides by reacting 2-naphthol with amides or nitriles in the presence of DMSO and DCE.

01 Mar 2023·Russian Journal of General Chemistry

Synthesis of Calix[4]resorcinarene and 1,1′-Dinaphthylmethane Amide Derivatives and Their Ability to Extract Metal Cations

Author: Maslennikova, V. I. ; Kamkina, A. V. ; Isaeva, S. A. ; Serkova, O. S. ; Glushko, V. V. ; Toropygin, I. Yu.

Aminolysis of ester derivatives of 1,1'-dinaphthylmethane and rctt-calix[4]resorcinarene afforded a series of ligands differing in the mol. platform structure, the number of electron-donor sites, the nature of terminal amide component, the nature and size of the spacers connecting the polycyclic core with the amide group.Using liquid extraction method, the effect of ligand structural features on its ability to recognize and bind s-, p-, d-, and f-metal cations was investigated, and the stoichiometry of formed complexes was calculated

01 Apr 2022·Research on Chemical Intermediates

Retrievable magnetic copper ferrite nanoparticles: an efficient catalyst for air oxidative cyclization of bisnaphthols

Author: Saeedian, Fateme ; Bahiraei, Hamed ; Shiri, Azam ; Khorramabadi-zad, Ahmad

Herein, a green and efficient heterogeneous and photocatalytic system for the oxidation of bisnaphthols in acetonitrile under light-emitting diode will be presented.In this reaction, aerial oxygen and H₂O₂ have been used as oxidant in the presence of copper ferrite nanoparticles and N-hydroxyphthalimide as an organic co-catalyst.Copper ferrite nanoparticles were magnetically separated, the efficiency of which remained nearly unchanged up to five cycles.Magnetic copper ferrite nanoparticles were synthesized by sol-gel method and characterized by XRD, FT-IR, SEM, TEM, VSM and DRS anal.In this project, both sets of diastereomers were formed.

100 Deals associated with ST-1859

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Phase 1	-	Alfasigma USA, Inc.	-
Alzheimer Disease	Phase 1	-	Sigma-Tau BV	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

ST-1859

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation