Last update 27 Feb 2026

AutoSynVax vaccine (Agenus/PureMHC)

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
AutologouscancervaccineAgenus, Neoantigen vaccine Agenus, ASV AGEN2017
+ [1]
Target-
Action
stimulants
Mechanism
Apoptosis stimulants, Immunostimulants
Therapeutic Areas
NeoplasmsDigestive System DisordersRespiratory Diseases+ [3]
Active Indication-
Inactive Indication
Advanced cancerBladder CancerBreast Cancer+ [7]
Originator Organization
Pure MHC LLCPhosImmune, Inc.PhosImmune, Inc.
Active Organization-
Inactive Organization
Agenus, Inc.Agenus, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with AutoSynVax vaccine (Agenus/PureMHC)
NCT03673020
/ CompletedPhase 1
Phase 1a First-in-Human Study of Safety and Tolerability of ASV® AGEN2017 With QS-21 Stimulon® Adjuvant as a Single Agent in Subjects With Solid Tumor at Risk of Relapse Undergoing Observation as SOC Following Complete Surgical Resection
NCT02992977
/ TerminatedPhase 1
A Phase 1 Study of Safety and Tolerability of AutoSynVax™ Vaccine as a Single Agent in Subjects With Advanced Cancer
100 Clinical Results associated with AutoSynVax vaccine (Agenus/PureMHC)
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100 Translational Medicine associated with AutoSynVax vaccine (Agenus/PureMHC)
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100 Patents (Medical) associated with AutoSynVax vaccine (Agenus/PureMHC)
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100 Deals associated with AutoSynVax vaccine (Agenus/PureMHC)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bladder CancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Breast CancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Colorectal CancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Head and Neck NeoplasmsPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Kidney NeoplasmsPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
MelanomaPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Non-Small Cell Lung CancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Soft Tissue SarcomaPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Uterine Cervical CancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
16 May 2019
Advanced cancerPhase 1
United States
Agenus, Inc.Agenus, Inc.
01 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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