Last update 08 May 2025

CDK2 (Plexium)

Overview

Basic Info

Drug Type
Degradable Molecular Glue
Synonyms
CDK2 Molecular Glue Ddegrader(Plexium), CDK2 bivalent degrader(Plexium)
Target
CDK2 x CRBN
Action
inhibitors
Mechanism
CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), CRBN inhibitors(Cereblon inhibitors)
Therapeutic Areas
NeoplasmsEndocrinology and Metabolic DiseaseSkin and Musculoskeletal Diseases+ [1]
Active Indication
Hormone receptor positive HER2 negative breast cancerEndometrial CarcinomaOvarian Cancer+ [1]
Inactive Indication-
Originator Organization
Plexium, Inc.Plexium, Inc.
Active Organization
Plexium, Inc.Plexium, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with CDK2 (Plexium)
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100 Translational Medicine associated with CDK2 (Plexium)
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100 Patents (Medical) associated with CDK2 (Plexium)
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100 Deals associated with CDK2 (Plexium)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Hormone receptor positive HER2 negative breast cancerPreclinical
United States
Plexium, Inc.Plexium, Inc.
29 Apr 2025
Endometrial CarcinomaPreclinical
United States
Plexium, Inc.Plexium, Inc.
08 Jun 2024
Ovarian CancerPreclinical
United States
Plexium, Inc.Plexium, Inc.
08 Jun 2024
ER-positive/HER2-negative Breast CancerDiscovery
United States
Plexium, Inc.Plexium, Inc.
05 Jan 2024
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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