Delving into the Latest Updates on Thymol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

Adiponectin receptors x NF-κB x PPARγ

Action

agonists, inhibitors

Mechanism

Adiponectin receptors agonists, NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors), PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)

Therapeutic Areas

Infectious Diseases

Active Indication

Gram-Negative Bacterial InfectionsBacillaceae InfectionsEscherichia Coli Infections+ [2]

Inactive Indication

Obesity

Originator Organization-

Active Organization

Wenzhou Medical College

University of Tabriz

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

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The prevalence of obesity in Mexico is 35.4%, and it is considered a risk factor for the development of diabetes, systemic arterial hypertension and dyslipidemia. Obesity due to the increased distribution and growth of adipose tissue creates a pro-inflammatory state induced by molecules secreted by the adipocytes themselves. Netrin-1 is a cell migration protein, which directs the recruitment, migration and entrapment of macrophages in different tissues, within adipose tissue the entrapment of macrophages induces the release of pro-inflammatory cytokines, which increase the secretion of pro-inflammatory adipokines. It has been found in high concentration in patients with obesity, insulin resistance and type 2 diabetes. Thymol is a phytopharmaceutical derived from oregano oil that has shown powerful anti-inflammatory and antioxidant effects through the stimulation of PPAR-gamma, adiponectin and inhibition of the NF-κB pathway mediated by the JNK pathway, pathways in which netrin-1 is involved in macrophage entrapment and recruitment.

Start Date01 Apr 2022

Sponsor / Collaborator-

CTRI/2020/04/024492

/ Not yet recruitingPhase 1IIT

Comparative clinical evaluation of 1% chlorhexidine and thymol varnish application with Scaling-Root Planing and Scaling-Root Planing alone in patients with chronic periodontitis.

Start Date20 Apr 2020

Sponsor / Collaborator-

100 Clinical Results associated with Thymol

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100 Translational Medicine associated with Thymol

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100 Patents (Medical) associated with Thymol

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3,409

Literatures (Medical) associated with Thymol

01 Sep 2025·New Biotechnology

Biodegradable zein/PEG nanofibers incorporated with natural antimicrobial compounds for eco-friendly food packaging

Article

Author: Šišková, Alena Opálková ; Matošková, Lucie ; Janalíková, Magda ; Bartošová, Lucie ; Krejčí, Ondřej ; Pleva, Pavel ; Sedlaříková, Jana ; Polášková, Martina

Nanofibrous zein/PEG based membranes incorporated with natural antimicrobial compounds were fabricated by electrospinning method. Structural and thermal analysis of prepared nanofibers revealed that the applied processing technique did not significantly affect the structure of pristine zein polymer. Morphological characterization showed a higher degree of polydispersity in the fibers modified with eugenol, thymol, nisin, or their combinations, and an average fiber diameter in the range from 300 to 390 nm. Nanofibrous samples with eugenol and thymol prevented the growth of Escherichia coli and Staphylococcus aureus, while the nisin or its mixtures with phenols proved a high antibacterial effect against Gram-positive Listeria ivanovii. Zein/PEG membranes with bioactive molecules significantly eliminated biofilm formation, with the most pronounced effect of zein/PEG/Eug/Thy combination. Biodegradability testing of bioactive membranes revealed no significant slowdown of degradation process in comparison to control sample. Zein/PEG hydrophilic nanofibers enriched with phenol/nisin combinations demonstrated a high potential for development of sustainable packaging to improve the shelf-life and quality of foods.

01 Sep 2025·FOOD CHEMISTRY

An innovative approach for the recovery of nobiletin, hesperidin, and other phytochemicals from tangerine leaves (Citrus reticulata) by-products using a solvent mixture based on natural compounds

Article

Author: Rodríguez-García, Camilo ; Palomeque, Liliam ; Montero, Lidia ; Parada-Alfonso, Fabián ; Sorita, Guilherme Dallarmi ; Strieder, Monique Martins ; Domínguez-Rodríguez, Gloria ; Ibáñez, Elena ; Bragagnolo, Felipe Sanchez

Citrus reticulata leaves, rich in phytochemicals, are underutilized by-products with sustainable valorization potential under Green Chemistry principles. This study developed an eco-friendly solvent combining thymol (Thy), oxalic acid (OA), and ethanol (EtOH) to extract nobiletin and hesperidin guided by COSMO-RS and high-intensity ultrasound (HIUS). The optimum solvent composition (0.9 % oxalic acid, 24.1 % thymol and 75 % EtOH) achieved higher yields of nobiletin (0.38 mg mL^-1), hesperidin (0.74 mg mL^-1) than pure EtOH (0.30 mg mL^-1 of nobiletin and 0.64 mg mL^-1 of hesperidin). HPLC-DAD-MS/MS and GC-MS analyses revealed that the optimized extract had a more complex phytochemical profile with a richer composition than the EtOH extract. Furthermore, optimized Thy-OA-EtOH extract exhibited superior bioactivity, with enhanced antioxidant capacity and neuroprotective effects (IC₅₀: 334.40 mg mL^-1) compared to HIUS-EtOH (IC₅₀: 1482.20 mg mL^-1). This study highlights the potential of natural compound mixtures with HIUS for extracting phytochemicals from citrus leaves for food and pharmaceutical applications.

01 Sep 2025·FOOD CHEMISTRY

Bacteria-triggered on-demand thymol release for salmon preservation: A self-destructive antibacterial strategy

Article

Author: Jia, Xiaohui ; Wu, Tong ; Zhu, Wanying ; Zhang, Zhou ; Dong, Yuhe ; Zhong, Tian ; Huang, Xiaoyu ; Yu, Xi ; Feng, Chun ; Xiao, Ying ; Jiang, Tao

To prevent foodborne pathogen invasion in fresh meat during storage, this study develops an enzyme/redox dual-responsive nanomaterial (Thy@MSN-S-S-Casein). Upon encountering bacteria, the casein shell is degraded by bacterial proteases, and glutathione (GSH) cleaves the disulfide bonds on the mesoporous silica nanoparticle (MSN) surface, releasing thymol to combat the bacteria. Trypsin and GSH triggered a cumulative release of 68.37 % thymol from Thy@MSN-S-S-Casein within 48 h, which was significantly higher than the release by trypsin alone (49.93 %) or without any activation (17.33 %). The antibacterial activities of Thy@MSN-S-S-Casein can be triggered by both artificially inoculated bacteria and naturally-infected bacteria on the salmon surfaces, leading to a reduction in the total viable count (TVC) in both experiments. Additionally, it inhibited the deterioration of the salmon fillets' quality indicators and extended their shelf life by about 3 days. This bacteria-triggered release strategy offers a promising self-destructive antibacterial approach for mitigating pathogen outbreaks in food preservation.

100 Deals associated with Thymol

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Obesity	Phase 2	Mexico	-	01 Apr 2022
Gram-Negative Bacterial Infections	Preclinical	China	Wenzhou Medical College	05 Apr 2023
Bacillaceae Infections	Preclinical	Iran	University of Tabriz	13 Apr 2010
Escherichia Coli Infections	Preclinical	Iran	University of Tabriz	13 Apr 2010
Pseudomonas aeruginosa infection	Preclinical	Iran	University of Tabriz	13 Apr 2010
Staphylococcus Aureus Infections	Preclinical	Iran	University of Tabriz	13 Apr 2010

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


FOCIS2017	Not Applicable	-	-	Thymol derived from Trachyspermum ammi	xqrjwllegi(knydqtohnk) = adfclgkcwm dptpwxgpfu (lrevdgnebq )	-	14 Jun 2017
ERS2013	Not Applicable	Cough	18	Nasal thymol	wpdwzumqpd(xwrtnzgfgz) = wapwsirfci pujmkqejkc (qhszmznzfx ) View more	-	01 Sep 2013
ERS2013	Not Applicable	Cough	18	Saline	wpdwzumqpd(xwrtnzgfgz) = nweomylrvu pujmkqejkc (qhszmznzfx ) View more	-	01 Sep 2013