Delving into the Latest Updates on Thymol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

Mechanism

Adiponectin receptors agonists, NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors), PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Obesity

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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The prevalence of obesity in Mexico is 35.4%, and it is considered a risk factor for the development of diabetes, systemic arterial hypertension and dyslipidemia. Obesity due to the increased distribution and growth of adipose tissue creates a pro-inflammatory state induced by molecules secreted by the adipocytes themselves. Netrin-1 is a cell migration protein, which directs the recruitment, migration and entrapment of macrophages in different tissues, within adipose tissue the entrapment of macrophages induces the release of pro-inflammatory cytokines, which increase the secretion of pro-inflammatory adipokines. It has been found in high concentration in patients with obesity, insulin resistance and type 2 diabetes. Thymol is a phytopharmaceutical derived from oregano oil that has shown powerful anti-inflammatory and antioxidant effects through the stimulation of PPAR-gamma, adiponectin and inhibition of the NF-κB pathway mediated by the JNK pathway, pathways in which netrin-1 is involved in macrophage entrapment and recruitment.

Start Date01 Apr 2022

Sponsor / Collaborator-

100 Clinical Results associated with Thymol

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100 Translational Medicine associated with Thymol

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100 Patents (Medical) associated with Thymol

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3,340

Literatures (Medical) associated with Thymol

01 Feb 2025·Neurochemical Research

Neuroprotective Effects of Thymol and p-Cymene in Immobilized Male rats through Alterations in Molecular, Biochemical, Histological, and Behavioral Parameters

Article

Author: Asle-Rousta, Masoumeh ; Peirovy, Yasaman

The research was conducted to examine the neuroprotective effect of thymol and its precursor p-cymene on chronic immobility stress in adult male Wistar rats. The rats were subjected to 2.5 h of stress every day for 14 consecutive days by placing them inside a restrainer. Thymol (10 mg/kg) and p-cymene (50 mg/kg) were given to the rats during the same period. The results showed that thymol and p-cymene prevented the increase of MDA level, decline of GSH level, and decrease of SOD and GPx activity in the hippocampus of rats exposed to stress. These monoterpenes also prevented the increase in the expression of Tnfa, Il1b, Tlr4, and Nfkb, and the decrease in the expression of Nrf2, Ho1, and Bdnf. In addition, thymol and p-cymene inhibited the increase in the expression and activity of acetylcholinesterase in the hippocampus of animals exposed to immobility and enhanced the expression of A7nachr. They also reduced neuronal death in the CA1 region of stressed animals and improved their performance in the Morris water maze and elevated plus maze tests. Based on these findings, thymol and p-cymene may be effective in preventing neurodegenerative diseases as they reduce oxidative stress and neuroinflammation, strengthen ACh signaling, and stimulate Bdnf expression.

01 Jan 2025·Food Microbiology

Antimicrobial activity of essential oil components against Escherichia coli depends on the food components present in a food matrix

Article

Author: Fernández-Segovia, Isabel ; Barat, José M ; Barat, José M. ; González-Bello, Concepción ; Jiménez, M, Consuelo ; Jiménez, M Consuelo ; Gómez-Llorente, Héctor ; Pérez-Esteve, Édgar ; Jiménez, M. Consuelo

Despite numerous studies evaluating the antimicrobial activity of essential oil components (EOCs) against different microorganisms, the effect of the composition of the matrix in which they are applied remains unexplored. Hence, the effect of different food components (i.e., proteins, lipids, carbohydrates, acids, ethanol) on vanillin antimicrobial activity was carried out by assessing the growth of E. coli at different incubation times (0, 1, 4, 8 and 24 h). Based on these outcomes, the food components that most adversely affected vanillin antimicrobial activity were subsequently tested with four other EOCs (i.e., carvacrol, eugenol, geraniol, thymol). The effective concentration of antimicrobials after coming into contact with food components was quantified. The results indicated that bovine serum albumin (BSA), sunflower oil and carbohydrates partially or completely inhibited the antimicrobial efficacy of the tested EOCs, and the inhibition rate depended on the specific EOC-food component combination. Geraniol was notably the most efficient with BSA present. Eugenol performed best with sunflower oil. Carvacrol, eugenol, geraniol and thymol were more effective than vanillin with D-lactose present. This study confirmed that loss of EOCs' effective concentration due to an interaction with food constituents is a significant cause of antimicrobial activity inhibition. These findings underscore the importance of considering matrix composition when selecting antimicrobials to combat a particular strain in real food applications.

01 Jan 2025·Food Chemistry

Protecting anthocyanins of postharvest blueberries through konjac glucomannan/low-acyl gellan gum coatings contained thymol microcapsule during low-temperature storage

Article

Author: Sameen, Dur E ; Lai, Yunya ; Xiao, Zhenkun ; Liu, Yaowen ; Sameen, Dur E. ; Chen, Mingrui ; Rong, Xingyu ; Qin, Wen ; Fu, Fengmei ; Zhu, Huiyan ; Tang, Tingting ; Xie, Jing

In order to protect the anthocyanins in blueberries during low-temperature storage, TMs/KGM/LAG (TKL) coatings were developed by composite thymol/β-cyclodextrin (β-CD) microcapsules (TMs), konjac glucomannan (KGM), and low acyl gellan gum (LAG). The results showed that the TMs prolonged the release of thymol for at least 30 d. The TKL was effective in maintaining the color of blueberry skin by regulating the activities of key enzymes for anthocyanin synthesis and degradation. Among the different treatment groups, TKL60 (thymol concentration of 60 mg/L) was the most effective in protecting anthocyanin. At 42 d of storage, the TKL60 group showed the highest anthocyanin levels of malvidin-3-O-galactoside (718.38 μg/g), delphinidin-3-O-galactoside (343.75 μg/g) and cyanidin-3-O-galactoside (40.67 μg/g). In addition, TKL60 treatment still showed good maintain the qualities of blueberries (weight loss, decay, hardness and TSS). Thus, this study provides a new approach to protect anthocyanin in blueberries after harvest during low-temperature storage.

100 Deals associated with Thymol

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Obesity	Phase 2	MX	-	01 Apr 2022

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ERS2013	Not Applicable	Cough	18	Nasal thymol	dwnbklejpv(vihjhcmvkj) = xcwwlanjbf gajoqgsael (dbqrfreamb ) View more	-	01 Sep 2013
				Saline	dwnbklejpv(vihjhcmvkj) = buixoeswgi gajoqgsael (dbqrfreamb ) View more