[Translation] A Phase Ic clinical study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of DA-302168S tablets after repeated oral administration in overweight/obese subjects
(1)评价 DA-302168S 片在超重/肥胖受试者中多次口服给药的安全性和耐受性;(2)评价 DA-302168S 片在超重/肥胖受试者中多次口服给药的药代动力学(PK)特征;(3)评价 DA-302168S 片在超重/肥胖受试者中多次口服给药的药效学(PD)特征;(4)基于 PopPK 分析方法,评价 DA-302168S 片在超重/肥胖受试者中的 PK 特征;(5)评价 DA-302168S 片的暴露与效应之间的相关性;(6)评价在超重/肥胖受试者中 DA-302168S 片对 QT 间期的影响
[Translation] (1) To evaluate the safety and tolerability of DA-302168S tablets after multiple oral administration in overweight/obese subjects; (2) To evaluate the pharmacokinetic (PK) characteristics of DA-302168S tablets after multiple oral administration in overweight/obese subjects; (3) To evaluate the pharmacodynamic (PD) characteristics of DA-302168S tablets after multiple oral administration in overweight/obese subjects; (4) To evaluate the PK characteristics of DA-302168S tablets in overweight/obese subjects based on the PopPK analysis method; (5) To evaluate the correlation between exposure and effect of DA-302168S tablets; (6) To evaluate the effect of DA-302168S tablets on the QT interval in overweight/obese subjects.