Delving into the Latest Updates on THDBH110 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

GLP-1R

Mechanism

GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Diabetes Mellitus, Type 2

Inactive Indication-

Originator Organization

Dongbao Zixing (Hangzhou) Biomedical Co., Ltd.

Active Organization

Dongbao Zixing (Hangzhou) Biomedical Co., Ltd.

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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主要目的：评估健康成人单次服用THDBH110胶囊后的安全性和耐受性；评估健康成人多次服用THDBH110胶囊后的安全性和耐受性；次要目的：评估健康成人单次服用THDBH110胶囊后的药代动力学特征；评估健康成人多次服用THDBH110胶囊后的药代/药效动力学特征；评估食物对健康成人服用THDBH110胶囊后的药代动力学特征的影响；评估健康成人单次服用THDBH110胶囊后对QTc间期的影响；初步探索健康成人服用THDBH110胶囊后在人体内的代谢转化情况。

[Translation]

Primary purpose: To evaluate the safety and tolerability of THDBH110 capsules after a single dose in healthy adults; To evaluate the safety and tolerability of THDBH110 capsules after multiple doses in healthy adults; Secondary purpose: To evaluate the pharmacokinetic characteristics of THDBH110 capsules after a single dose in healthy adults; To evaluate the pharmacokinetic/pharmacodynamic characteristics of THDBH110 capsules after multiple doses in healthy adults; To evaluate the effect of food on the pharmacokinetic characteristics of THDBH110 capsules after healthy adults take THDBH110 capsules; To evaluate the effect of a single dose of THDBH110 capsules on the QTc interval in healthy adults; To preliminarily explore the metabolic transformation of THDBH110 capsules in the human body after healthy adults take them.

Start Date29 Nov 2023

Sponsor / Collaborator

Dongbao Zixing (Hangzhou) Biomedical Co., Ltd.

100 Clinical Results associated with THDBH110

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100 Translational Medicine associated with THDBH110

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100 Patents (Medical) associated with THDBH110

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100 Deals associated with THDBH110

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