Last update 28 Jan 2026

Domatinostat tosylate/Sirolimus

Overview

Basic Info

Drug Type
Non-degrading molecular glue
Synonyms
Domatinostat/Sirolimus, HLX-4310, VUJ 100
+ [2]
Target
HDACs x KDM1A x mTOR
Action
inhibitors
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), KDM1A inhibitors(Lysine-specific histone demethylase 1 inhibitors), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors)
Therapeutic Areas
NeoplasmsSkin and Musculoskeletal DiseasesOther Diseases
Active Indication
Osteosarcoma
Inactive Indication-
Originator Organization
Vuja De Sciences, Inc.Vuja De Sciences, Inc.
Active Organization
Vuja De Sciences, Inc.Vuja De Sciences, Inc.
Inactive Organization-
License Organization
Healx Ltd.Healx Ltd.
Vuja De Sciences, Inc.Vuja De Sciences, Inc.
Drug Highest PhaseIND Approval
First Approval Date-
Regulation-

Related

100 Clinical Results associated with Domatinostat tosylate/Sirolimus
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100 Translational Medicine associated with Domatinostat tosylate/Sirolimus
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100 Patents (Medical) associated with Domatinostat tosylate/Sirolimus
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100 Deals associated with Domatinostat tosylate/Sirolimus
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
OsteosarcomaIND Approval
United States
Vuja De Sciences, Inc.Vuja De Sciences, Inc.
01 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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