Last update 26 Feb 2026

GEM-144

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GEM-144, GEM144
Target
HDAC11 x POLA1
Action
inhibitors
Mechanism
HDAC11 inhibitors(histone deacetylase 11 inhibitors), POLA1 inhibitors(DNA polymerase alpha subunit inhibitors), Epigenetic drug
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Colorectal Cancer
Inactive Indication-
Originator Organization
University of MilanUniversity of Milan
Active Organization
University of MilanUniversity of MilanSaint Mary's CollegeSaint Mary's CollegeThe Institute of Molecular Biology & GeneticsThe Institute of Molecular Biology & Genetics
+ [1]
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with GEM-144
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100 Translational Medicine associated with GEM-144
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100 Patents (Medical) associated with GEM-144
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100 Deals associated with GEM-144
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPreclinical
United States
Saint Mary's CollegeSaint Mary's College
29 Apr 2025
Colorectal CancerPreclinical
Italy
University of MilanUniversity of Milan
29 Apr 2025
Colorectal CancerPreclinical
Italy
The Institute of Molecular Biology & GeneticsThe Institute of Molecular Biology & Genetics
29 Apr 2025
Colorectal CancerPreclinical
Lebanon
American University of BeirutAmerican University of Beirut
29 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Clinical Trial

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Approval

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Regulation

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