Probiotic CECT 7746(AB Biotics)

Exploratory, phase I study to evaluate the clinical efficacy of Streptococcus dentisani CECT 7746 in the risk reduction of caries. Patients who meet the inclusion and exclusion criteria will be randomized and receive the corresponding treatment. The study will follow a randomized design, with two groups in parallel (placebo group and probiotic group) of prospective, double-blind follow-up, for a period of 45 days. The present study will be conducted in a single center and will include a total of 70 patients. The present study has a double main objective:
Evaluate whether the administration of the probiotic S. dentisani CECT 7746 alkalizes the basal pH of saliva.
Test the safety and tolerability of the probiotic
Secondary
Evaluate other microbiological parameters associated with caries risk such as the presence of microorganisms such as S. mutans.
Evaluate the presence in the mouth and colonization capacity of S. dentisani.
Evaluate the lactic acid and the pH of the ex vivo plate before and after the administration of a sugar solution
Evaluate the salivary pH before and after the administration of a sugar solution
Evaluate the salivary pH before brushing with water.
Evaluate the buffer capacity of saliva