Delving into the Latest Updates on Fluorapacin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

BFBTS, FLP

Target

Tubulin

Mechanism

Tubulin inhibitors

Therapeutic Areas

NeoplasmsRespiratory Diseases

Active Indication

Lung CancerNon-Small Cell Lung Cancer

Inactive Indication

Advanced cancerAdvanced Malignant Solid Neoplasm

Originator Organization

Acea Bio (Hangzhou) Co., Ltd.

Active Organization

ACEA Therapeutics, Inc.Startup

Inactive Organization

Acea Bio (Hangzhou) Co., Ltd.

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure

Molecular FormulaC14H12F2S3

InChIKeyXCOWUOOCXCXCNS-UHFFFAOYSA-N

CAS Registry869811-23-4

1) Determine the tolerance of this product for 72 hours and its dose-limiting toxicity in humans 2) Investigate the pharmacokinetic behavior of fluphenazine and its metabolites 3) Explore the relationship between the dose, pharmacokinetic parameters and efficacy of this product 4) Preliminary study of the efficacy of fluphenazine 5) Provide a safe and effective reasonable plan for Phase II clinical research

Start Date-

Sponsor / Collaborator-

CTR20130888 / RecruitingPhase 1

氟莱哌素注射液联合培美曲赛治疗晚期NSCLC剂量探索I期临床试验

[Translation] Phase I dose-finding clinical trial of fluphenazine injection combined with pemetrexed in the treatment of advanced NSCLC

(1)确定联合给药下氟莱哌素注射液的剂量；(2)确定联合方案的MTD、DLT；(3)考察药代动力学行为并计算药代动力学参数。(4)评估耐受性和安全性。(5)初步考察联合给药的疗效。(6)为Ⅱ期临床提供安全有效的合理方案。

[Translation]

(1) Determine the dose of fluphenazine injection under combined administration; (2) Determine the MTD and DLT of the combined regimen; (3) Investigate the pharmacokinetic behavior and calculate the pharmacokinetic parameters. (4) Evaluate tolerability and safety. (5) Preliminarily investigate the efficacy of combined administration. (6) Provide a safe and effective reasonable regimen for Phase II clinical trials.

Start Date-

Sponsor / Collaborator-

NCT01361529 / Unknown statusPhase 1

Phase 1 Study of FLP Injection on Tumor Patients

The purpose of this study is to determine the tolerance and maximum tolerated dose (MTD) for FLP Injection with multiple dose in tumor patients.

Start Date01 Jun 2009

Sponsor / Collaborator

Acea Bio (Hangzhou) Co., Ltd.

100 Clinical Results associated with Fluorapacin

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100 Translational Medicine associated with Fluorapacin

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100 Patents (Medical) associated with Fluorapacin

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71

Literatures (Medical) associated with Fluorapacin

01 Jun 2024·Klinische Monatsblätter für Augenheilkunde

Effective Focal Laser Photocoagulation for Persistent Central Serous Chorioretinopathy: A Forgotten Technique

Article

Author: Kiraly, Peter

We report a case of a patient with persistent central serous chorioretinopathy (CSC) who was on the waiting list for half-dose photodynamic therapy (PDT). As the patient's visual function began to deteriorate, patient opted for focal laser photocoagulation (FLP) targeting the presumed leakage site in the superior part of the macula. One month after the FLP treatment, there was complete resolution of SRF accompanied by improved visual function. In light of global verteporfin shortages, limited access to PDT centers, and poor efficacy from other treatment modalities, FLP emerges as an effective treatment option for CSC patients with extrafoveal leakage. Yet, many CSC patients with extrafoveal leakage, who could be effectively treated with FLP, are often merely monitored, experiencing fluctuating SRF and a gradual, irreversible vision decline. Despite FLP's historical presence in CSC treatment, our case serves as an important reminder for retinal specialists to reconsider this treatment approach in selected CSC patients.

25 Dec 2023·Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Enzyme production mechanism of anaerobic fungus Orpinomyces sp. YF3 in yak rumen induced by different carbon source].

Article

Author: Wang, Lamei ; Cao, Yangchun ; Zhou, Linlin ; Li, Yong ; Yao, Junhu ; Zhao, Congcong ; Zhang, Fan ; DU, Xue'er

In order to investigate the enzyme production mechanism of yak rumen-derived anaerobic fungus Orpinomyces sp. YF3 under the induction of different carbon sources, anaerobic culture tubes were used for in vitro fermentation. 8 g/L of glucose (Glu), filter paper (Flp) and avicel (Avi) were respectively added to 10 mL of basic culture medium as the sole carbon source. The activity of fiber-degrading enzyme and the concentration of volatile fatty acid in the fermentation liquid were detected, and the enzyme producing mechanism of Orpinomyces sp. YF3 was explored by transcriptomics. It was found that, in glucose-induced fermentation solution, the activities of carboxymethyl cellulase, microcrystalline cellulase, filter paper enzyme, xylanase and the proportion of acetate were significantly increased (P < 0.05), the proportion of propionate, butyrate, isobutyrate were significantly decreased (P < 0.05). The results of transcriptome analysis showed that there were 5 949 differentially expressed genes (DEGs) between the Glu group and the Flp group, 10 970 DEGs between the Glu group and the Avi group, and 6 057 DEGs between the Flp group and the Avi group. It was found that the DEGs associated with fiber degrading enzymes were significantly up-regulated in the Glu group. Gene ontology (GO) function enrichment analysis identified that DEGs were mainly associated with the xylan catabolic process, hemicellulose metabolic process, β-glucan metabolic process, cellulase activity, endo-1,4-β-xylanase activity, cell wall polysaccharide metabolic process, carbohydrate catabolic process, glucan catabolic process and carbohydrate metabolic process. Moreover, the differentially expressed pathways associated with fiber degrading enzymes enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were mainly starch and sucrose metabolic pathways and other glycan degradation pathways. In conclusion, Orpinomyces sp. YF3 with glucose as carbon source substrate significantly increased the activity of cellulose degrading enzyme and the proportion of acetate, decreased the proportion of propionate, butyrate and isobutyrate. Furthermore, the degradation ability and energy utilization efficiency of fungus in the presence of glucose were improved by means of regulating the expression of cellulose degrading enzyme gene and participating in starch and sucrose metabolism pathway, and other glycan degradation pathways, which provides a theoretical basis for the application of Orpinomyces sp. YF3 in practical production and facilitates the application of Orpinomyces sp. YF3 in the future.

31 Aug 2023·The European journal of prosthodontics and restorative dentistry

Mechanical Characteristics of Composite Resins Produced by Additive and Subtractive Manufacturing.

Article

Author: Kιlιçarslan, M A ; Sahin, Z ; Yιkιcι, C ; Ozer, N E

INTRODUCTIONThe aim of the study was to evaluate the mechanical characteristics of resin composites produced by additive and subtractive manufacturing.METHODSSix composite resin materials produced by subtractive (Vita Enamic-VE, Cerasmart-CE, Lava Ultimate-LU) and additive manufacturing (Varseo Smile Crown plus-VSC, Saremco Print Crowntec-SPC, Formlabs 3B Permanent crown-FLP) were selected. The three-point bending test was performed, and surface hardness of test specimens was measured.RESULTSThe flexural strength values of CE, SPC and LU test groups were found to be statistically higher when compared to VE, FLP and VSC test groups (p⟨0.0033). The modulus of elasticity values of the test specimens was listed as VE>LU>CE>SPC>FLP>VSC. The FLP group [35.11(4.46)] had the lowest surface hardness values, whereas the VE group [252.50 (21.5)] had the highest values. Other groups were listed as LU⟩CE⟩SPC⟩VSC in terms of surface hardness.CONCLUSIONSAccording to the ISO 6872:2015, the flexural strengths of all resin composites were found to be acceptable for single unit fixed restorations. However, the VSC group's flexural strength is suitable for inlay, onlay, veneer restorations or single-unit anterior fixed dental prostheses. Also, VSC may not be a suitable choice for posterior restorations due to its low flexural strength.

100 Deals associated with Fluorapacin

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Lung Cancer	Phase 2	CN	ACEA Therapeutics, Inc.Startup	30 Jan 2022
Non-Small Cell Lung Cancer	Phase 1	CN	-	13 Nov 2013
Advanced Malignant Solid Neoplasm	Discovery	CN	-	13 Nov 2013
Advanced cancer	Discovery	CN	Acea Bio (Hangzhou) Co., Ltd.	01 Jun 2009

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASCO2006	Phase 3	Advanced Gastric Adenocarcinoma First line	220	FLO	qrceiycbhu(vngjewjubr) = obyizfbkyl tdwurjaons (paskwrclpc ) View more	Positive	20 Jun 2006
				FLP	qrceiycbhu(vngjewjubr) = uolsozncgs tdwurjaons (paskwrclpc ) View more
ASCO2004	Not Applicable	recurrent gastric cancer First line	111	FLP	(vufvelmwwr) = hjavdatbje figbxymyeo (fcdloinvvp ) View more	-	15 Jul 2004
				S-1	(vufvelmwwr) = dupvyigncn figbxymyeo (fcdloinvvp ) View more