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Last update 20 Mar 2025
OBT-357
Last update 20 Mar 2025
Overview
Basic Info
Drug Type Monoclonal antibody |
Synonyms + [7] |
Target |
Action inhibitors |
Mechanism BST1 inhibitors(ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 1 |
First Approval Date- |
Regulation- |
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Related
1
Clinical Trials associated with OBT-357NCT02353143
First in Man Study With MEN1112, a CD157 Targeted Monoclonal Antibody, in Relapsed or Refractory Acute Myeloid Leukemia.
100 Clinical Results associated with OBT-357
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100 Translational Medicine associated with OBT-357
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100 Patents (Medical) associated with OBT-357
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1
Literatures (Medical) associated with OBT-35730 May 2017Oncotarget
Targeting CD157 in AML using a novel, Fc-engineered antibody construct
Article
Author: Lichtenegger, Felix S. ; Bisht, Arnima ; Hiddemann, Wolfgang ; Altmann, Torben ; Aud, Dee ; Pombo-Villar, Esteban ; Köhnke, Thomas ; Rohlff, Christian ; Bögeholz, Jan ; Bücklein, Veit ; Wilson, Keith ; Krupka, Christina ; Dusek, Rachel ; Subklewe, Marion ; Roiss, Michael ; Do, To Uyen ; Terrett, Jon
100 Deals associated with OBT-357
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Refractory acute myeloid leukemia | Phase 1 | France | 01 Dec 2014 | |
| Refractory acute myeloid leukemia | Phase 1 | Germany | 01 Dec 2014 | |
| Refractory acute myeloid leukemia | Phase 1 | Belgium | 01 Dec 2014 | |
| Refractory acute myeloid leukemia | Phase 1 | Italy | 01 Dec 2014 | |
| Refractory acute myeloid leukemia | Phase 1 | Spain | 01 Dec 2014 | |
| Relapsing acute myeloid leukemia | Phase 1 | Germany | 01 Dec 2014 | |
| Relapsing acute myeloid leukemia | Phase 1 | Belgium | 01 Dec 2014 | |
| Relapsing acute myeloid leukemia | Phase 1 | Italy | 01 Dec 2014 | |
| Relapsing acute myeloid leukemia | Phase 1 | Spain | 01 Dec 2014 | |
| Relapsing acute myeloid leukemia | Phase 1 | France | 01 Dec 2014 |
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