Delving into the Latest Updates on TranspoCART19(Instituto de Investigación Biomédica de Salamanca) with Synapse

Overview

Basic Info

Drug Type

Autologous CAR-T

Synonyms-

Target

CD19

Mechanism

CD19 modulators(B-lymphocyte antigen CD19 modulators)

Therapeutic Areas

NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases

Active Indication

B-cell lymphoma recurrentB-cell lymphoma refractory

Inactive Indication-

Originator Organization

Instituto de InvestigaciÃ³n BiomÃ©dica de Salamanca - IBSAL

Active Organization

Instituto de InvestigaciÃ³n BiomÃ©dica de Salamanca - IBSAL

Inactive Organization-

Drug Highest PhasePhase 1/2

First Approval Date-

Regulation-

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Phase I/IIa multicentre phase I/IIa study of infusion of autologous peripheral blood T lymphocytes expanded and genetically modified using Sleeping Beauty family transposons to express a chimeric antigenic receptor with anti-CD19 specificity conjugated to the 4-1BB co-stimulatory and signal-transduction region CD3z and huEGFRt (TranspoCART19) in patients with relapsed or refractory B-cell lymphoma.

Start Date-

Sponsor / Collaborator-

NCT06378190 / RecruitingPhase 1/2

Multicentre Phase I/IIa Study of Infusion of Autologous Peripheral Blood T Lymphocytes Expanded and Genetically Modified Using Sleeping Beauty Family Transposons to Express a Chimeric Antigenic Receptor With Anti-CD19 Specificity Conjugated to the 4-1BB Co-stimulatory Region and CD3z and huEGFRt Signal Transmission (TranspoCART19) in Patients With Relapsed or Refractory B-cell Lymphoma

The goal of this clinical trial is to to evaluate the safety and efficacy of TranspoCART19 in patients with relapsed/refractory B-lymphoma. The main questions it aims to answer are:
Maximum tolerated dose (MTD) Response rates Participants will be treated with the investigational medicinal product and will be followed for 36 months.

Start Date11 Mar 2024

Sponsor / Collaborator

Instituto de InvestigaciÃ³n BiomÃ©dica de Salamanca - IBSAL

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100 Clinical Results associated with TranspoCART19(Instituto de Investigación Biomédica de Salamanca)

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100 Translational Medicine associated with TranspoCART19(Instituto de Investigación Biomédica de Salamanca)

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100 Patents (Medical) associated with TranspoCART19(Instituto de Investigación Biomédica de Salamanca)

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100 Deals associated with TranspoCART19(Instituto de Investigación Biomédica de Salamanca)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
B-cell lymphoma recurrent	Phase 2	ES	Instituto de InvestigaciÃ³n BiomÃ©dica de Salamanca - IBSAL	11 Mar 2024
B-cell lymphoma refractory	Phase 2	ES	Instituto de InvestigaciÃ³n BiomÃ©dica de Salamanca - IBSAL	11 Mar 2024