Delving into the Latest Updates on Ecenofloxacin hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ecenofloxacin

Target

Bacterial DNA gyrase

Action

inhibitors

Mechanism

Bacterial DNA gyrase inhibitors(Bacterial DNA gyrase inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Bacterial Infections

Inactive Indication-

Originator Organization

CJ CheilJedang Corp.

Active Organization

Wakunaga Pharmaceutical Co., Ltd.

Roussel Uclaf SA

Inactive Organization

CJ CheilJedang Corp.CJ Group

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC19H22ClFN4O3

InChIKeyOTJVJUVCWOCNQA-ZLLRUXOSSA-N

CAS Registry162424-67-1

View All Structures (2)

Antibiotics like enrofloxacin are widely used in animal farming to treat and prevent bacterial infections. A previous study in poultry farms has shown that yardmen show significant concentrations of administered antibiotics in their urine. It is currently unclear how poultry yardmen are exposed to the administered antibiotics. The objective of this exemplarily study is to obtain information on the pharmacokinetics of the different uptake routes (oral, inhaled or dermal).

Start Date27 Apr 2018

Sponsor / Collaborator

Fraunhofer Institute for Chemical Technology

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100 Clinical Results associated with Ecenofloxacin hydrochloride

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100 Translational Medicine associated with Ecenofloxacin hydrochloride

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100 Patents (Medical) associated with Ecenofloxacin hydrochloride

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3,511

Literatures (Medical) associated with Ecenofloxacin hydrochloride

01 Oct 2025·Talanta

Inspired by enzyme-linked aptamer assay: Polydopamine coating-enhanced colorimetric-photothermal lateral flow assay for detection of enrofloxacin

Article

Author: Chen, Peifang ; Qin, Mingwei ; Li, Yu ; Qi, Shuo ; Tang, Dayun ; Wang, Zhouping ; Ding, Ning

Developing rapid and portable tests for enrofloxacin (ENR) residues is critical to ensuring food safety. At present, aptamer-based lateral flow analysis (Apt-LFA) has received extensive attention due to low cost and user friendliness. The study presents a novel LFA for the sensitive detection of ENR, using bovine serum albumin-enrofloxacin (BSA-ENR) conjugates as the competitor. Based on the competitive binding between ENRapt and both ENR and BSA-ENR, we developed an indirect competitive enzyme-linked aptamer assay (icELAA). Leveraging the above findings, an Apt-LFA for rapid ENR analysis was designed. Polydopamine was in situ grown on plasmonic Au nanorods to serve as signal probes (Au NRs/PDA), with improved colorimetric and photothermal responses and enhanced structural stability. The dual-readout Apt-LFA achieved a visual limit of detection of 5 ng/mL, about 20 times more sensitive than conventional Au nanoparticles-based LFA. Notably, the Au NRs/PDA-LFA simplifies the assay process of HRP-based icELAA, presenting a flexible and promising tool for extensive food safety assessment.

01 Aug 2025·Bioresource Technology

Metabolic responses of microalgal-bacterial granular sludge to enrofloxacin and sulfamethoxazole exposure

Article

Author: Shi, Yuting ; Xu, Chengxiang ; Xu, Kaiyang ; Li, Anjie ; Chen, Changqing ; Ji, Bin

This study examined the removal performance and responses of the microalgal-bacterial granular sludge (MBGS) system to enrofloxacin (ENR), sulfamethoxazole (SMX), and their combination. Results showed that MBGS could achieve 73.2 % and 64.0 % removals of ENR and SMX at 1 mg/L of mixed antibiotics, while ENR severely affected organics removal (from 84.5 % to 74.7 %). Antibiotic exposures could raise reactive oxygen species levels, thereby disrupted cellular structures and energy metabolism. ENR had the most significant disruptive effect, markedly reducing the abundance of Oscillatoriales and impairing their interactions with other taxa. In contrast, Xanthomonadales and Micrococcales were essential for sustaining energy metabolism under ENR stress, while Hyphomicrobiales demonstrated strong adaptability to these antibiotics. Notably, the combination of ENR and SMX mitigated oxidative stress, facilitating the growth of Rhodospirillales and Chloroflexales. These findings provide insights into microbial adaptation mechanisms under antibiotic pressure and offer guidance for optimizing wastewater treatment strategies in antibiotic-contaminated environments.

01 Jul 2025·Food Chemistry

Quasi-solid hydrogel electrolyte/nitrogen dot-based electrochemiluminescence sensor for enrofloxacin detection in milk

Article

Author: Ma, Qiang ; Liu, Ning ; Wang, Jinling ; Wang, Peilin ; Li, Zhenrun

In this study, a novel quasi-solid hydrogel-based electrochemiluminescence (ECL) sensor was developed to detect enrofloxacin (ENR) in milk. First, nitrogen-rich quantum dots ((5-AT-co-CA)-N-dots) with high luminescence efficiency were synthesized and served cathodic ECL luminophores. Second, the P(AM-co-AMPS)-PEDOT:PSS (PAMES) hydrogel was prepared as a quasi-solid electrolyte. The hydrogel exhibited high ionic conductivity (52.5 mS cm^-1), excellent adhesion properties, high transparency (83 %), and high water content (89 %). The ECL signal of (5-AT-co-CA)-N-dots was enhanced by 4.3 times in is PAMES hydrogel compared to the solution. The solventless sensing system based on quasi-solid hydrogel electrolyte addressed the limitations of leakage and instability of traditional liquid electrolytes, thereby improving the portability and environmental adaptability of the sensor. Furthermore, a molecularly imprinted sensing system was constructed to detect ENR based on the PAMES hydrogel. This novel ECL sensor significantly simplified the operations and expanded s potential sensing applications.

100 Deals associated with Ecenofloxacin hydrochloride

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