Delving into the Latest Updates on Bepridil hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

angopril, Bapadin, Bepridil

+ [15]

Target

SCNA x VDCCs x VGKCs

Action

blockers

Mechanism

SCNA blockers(Sodium voltage-gated channel alpha subunits blockers), VDCCs blockers(Voltage-gated calcium channel blockers), VGKCs blockers(Voltage-gated potassium channel blockers)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesOther Diseases+ [3]

Active Indication

Atrial FibrillationAngina PectorisTachycardia, Ventricular+ [1]

Inactive Indication-

Originator Organization

Johnson & Johnson

Active Organization

Organon KK

Dana-Farber Cancer Institute, Inc.

Inactive Organization

Johnson & Johnson Pharmaceutical Research & Development LLC

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (28 Dec 1990),

Angina PectorisAtrial FibrillationTachycardia

Regulation-

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Structure/Sequence

Molecular FormulaC24H35ClN2O

InChIKeyJXBBWYGMTNAYNM-UHFFFAOYSA-N

CAS Registry68099-86-5

Topological indices are effective tools for modeling and predicting the molecular structure and physicochemical properties of medications, eliminating the need for lengthy laboratory procedures. Topological indices offer the benefit of acting as fundamental numerical indicators in models related to quantitative structure-property relationships (QSPR) and quantitative structure-activity relationships (QSAR). In this research, we investigate degree-based topological indices (TIs) that serve as molecular descriptors for the QSPR analysis of antiviral medications such as Favipiravir, Sertraline, Chloroquine, Ribavirin, Bepridil, Clomifene, Galidesivir, Nilotinib, and Brincidofovir, which affect the interactions between viruses and human proteins. We examine both linear and multilinear QSPR models to analyze the connections between different physical and chemical properties including molecular polarizability (MP), Log P, molecular refractivity (MR), and molecular weight (MW) and the numerical values associated with these drugs. Our results indicate a strong correlation between the topological indices of these antiviral medications and their physical and chemical characteristics.

01 Jun 2025·Journal of Arrhythmia

Clinical insights into the role of bepridil in recurrence prevention after ablation of persistent atrial fibrillation

Article

Author: Murotani, Kenta ; Okumura, Yasuo ; Wakamatsu, Yuji ; Hirata, Moyuru ; Watanabe, Ryuta ; Sawada, Masanaru ; Nagashima, Koichi ; Otsuka, Naoto ; Saito, Yuji ; Hirata, Shu ; Kurokawa, Sayaka

Abstract:

Background:

The role of bepridil in preventing atrial fibrillation (AF) recurrence following ablation for persistent atrial fibrillation (PerAF) remains uncertain, particularly in patients with severe atrial substrates.

Methods:

This retrospective study included 232 consecutive PerAF patients who underwent AF ablation between 2014 and 2019. Among them, 162 received bepridil for 3 months post‐ablation (Bepridil group), while 70 received no antiarrhythmic drugs (No‐AADs group). Baseline characteristics, procedural details, and outcomes were compared. Kaplan–Meier analysis and Cox regression models were used to evaluate AF/atrial tachycardia (AT) recurrence, with bepridil use treated as a time‐dependent covariable.

Results:

The Bepridil group had a higher body mass index (25.1 ± 3.7 vs. 23.8 ± 3.9), a higher prevalence of patients with a LAD >40 mm and a LAV >50 mL (67.9% vs. 47.1%, 64.2% vs. 48.5%, respectively), and lower left atrial appendage flow velocity (37.6 ± 15.0 vs. 42.7 ± 20.5 cm/min). They more frequently underwent intracardiac atrial cardioversion (61.7% vs. 40.0%) and additional extra‐pulmonary vein ablation (35.2% vs. 15.7%), but were less likely to receive balloon‐based ablation (39.5% vs. 62.9%) (p < 0.05 for all comparison). During a median follow‐up of 23.3 months, AF/AT‐free survival at 2 years was comparable between the Bepridil and No‐AADs groups (80.4% vs. 81.7%; p = 0.61). This finding remained consistent after adjusting for baseline characteristics and considering bepridil as a time‐dependent covariable. No bepridil‐related adverse events occurred.

Conclusion:

Bepridil may have a limited role in preventing AF/AT recurrence in PerAF patients, particularly those with severe atrial substrates. However, its overall impact appears to be small, warranting further investigation.

01 Jun 2025·British Journal of Pharmacology

Chemosensory signalling in human sperm is controlled by Ca²⁺ influx via CatSper and Ca²⁺ clearance via plasma membrane Ca²⁺ ATPases

Article

Author: Jan Jikeli ; W. Felix Zhu ; Vesna Bojovic ; Christoph Brenker ; Carla Trugge ; Jens Münchow ; David Fußhöller ; Louisa Temme ; Leonie Herrmann ; Teresa Mittermair ; Timo Strünker ; U. Benjamin Kaupp

Abstract:

Background and Purpose:

Loss of function of the sperm‐specific Ca2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca2+ concentration and, thereby, the motility of human sperm. Activation of CatSper by oviductal ligands evokes a transient Ca2+ increase, which entails changes in the flagellar beat that are required for fertilisation. The CatSper‐mediated Ca2+ influx has been studied extensively, whereas the mechanisms underlying Ca2+ clearance and recovery from Ca2+ influx have remained ill‐defined.

Experimental Approach:

We examined how pharmacological suppression of Ca2+ export from the cytosol into the extracellular space or Ca2+ uptake into intracellular stores affects the resting Ca2+ concentration and CatSper‐mediated Ca2+ signals in human sperm. We studied sperm of healthy volunteers and infertile men lacking functional CatSper channels, using kinetic Ca2+‐ and pH‐fluorometry as well as patch‐clamp recordings.

Key Results:

We show that Ca2+ entering human sperm via CatSper is predominantly, if not exclusively, exported by plasma membrane Ca2+ ATPases (PMCAs). Na+/Ca2+ exchange and Ca2+ uptake into intracellular stores or mitochondria play no or only a negligible role in Ca2+ clearance in human sperm.

Conclusions and Implications:

Ca2+ signalling in human sperm is controlled by the functional interplay of CatSper and PMCAs, that is, the balance between Ca2+ influx and Ca2+ export that is required for human sperm function and fertilisation.

100 Deals associated with Bepridil hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D00631	Bepridil hydrochloride	C08EA02	DB01244

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Tachycardia, Ventricular	Japan	Organon KK	03 Jul 1992
Angina Pectoris	United States	Johnson & Johnson Pharmaceutical Research & Development LLC	28 Dec 1990
Atrial Fibrillation	United States	Johnson & Johnson Pharmaceutical Research & Development LLC	28 Dec 1990
Tachycardia	United States	Johnson & Johnson Pharmaceutical Research & Development LLC	28 Dec 1990