Delving into the Latest Updates on Carbendazim with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Benzimate

+ [5]

Target

DNA-directed DNA polymerase x RT x Tubulin

Mechanism

DNA-directed DNA polymerase inhibitors, RT inhibitors(Reverse transcriptase inhibitors), Tubulin inhibitors

Therapeutic Areas

NeoplasmsImmune System DiseasesInfectious Diseases+ [1]

Active Indication-

Inactive Indication

HIV InfectionsNeoplasms

Originator Organization

Procter & Gamble Co.

Active Organization-

Inactive Organization

ImQuest BioSciences, Inc.Arisyn Therapeutics Inc

Procter & Gamble Co.

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

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Structure

Molecular FormulaC9H9N3O2

InChIKeyTWFZGCMQGLPBSX-UHFFFAOYSA-N

CAS Registry10605-21-7

This research introduces a novel composite material, cobalt hydroxide/titanium dioxide (Co(OH)₂/TiO₂), engineered for the detection of the fungicide carbendazim (CBZ) in environmental samples. A glassy carbon electrode (GCE) was modified with Co(OH)₂/TiO₂ to create an electrochemical sensor capable of highly sensitive CBZ detection. Differential pulse voltammetry was utilized to quantify various CBZ concentrations, revealing that the Co(OH)₂/TiO₂-GCE sensor provided robust response signals across a concentration range from 0.039 μM to 2630.1 μM, with a detection limit of 0.007 μM. The sensor demonstrated notable stability, reproducibility, and selectivity towards CBZ, attributable to the synergistic effects of Co(OH)₂/TiO₂. Additionally, the Co(OH)₂/TiO₂-GCE sensor proved effective for analyzing CBZ in fruit and vegetable samples. Thus, this sensor presents significant potential for widespread application in environmental monitoring and food safety assessments.

01 Jan 2025·Talanta

Highly sensitive detection of carbendazim in agricultural products using colorimetric and photothermal lateral flow immunoassay based on plasmonic gold nanostars

Article

Author: Wu, Qi ; Zhang, Yaohai ; He, Yue ; Zhao, Qiyang ; Wang, Chengqiu ; Cui, Yongliang ; Zhang, Tian ; Xie, Longyingzi ; Liu, Lei

The wide use and high toxicity of carbendazim (CBD) in agriculture pose unprecedented demands for convenient, sensitive, and cost-effective on-site monitoring. Herein, we propose a novel colorimetric and photothermal dual-mode lateral flow immunoassay (LFIA) based on plasmonic gold nanostars (AuNSs) for CBD detection in agricultural products. The AuNSs were synthesized via a rapid seed-mediated growth method (with growth time of ∼5 s). A stable immunoprobe was formed by adsorbing CBD antibodies onto AuNSs. This immunoprobe exhibited high conversion efficiency and sensitivity in photothermal detection with a low limit of detection (LOD) of 0.28 ng mL^-1. The LOD of the colorimetric mode was higher (0.48 ng mL^-1). The results of CBD detection in various agricultural products aligned well with ultra-performance liquid chromatography tandem mass spectrometry. Overall, our LFIA shows excellent sensitivity, specificity, reproducibility, and rapidness in CBD detection, and thus is a highly potential on-site platform in resource-limited environments.

01 Jan 2025·Journal of Pharmaceutical and Biomedical Analysis

Method validation and determination of pesticides in Mikania glomerta Spreng tincture by direct injection and UPLC-MS/MS analysis

Article

Author: de Oliveira, Angélica Castanheira ; Ferraris, Fausto Klabund ; da Nobrega, Armi Wanderley ; de Brito, Thais Morais ; Amendoeira, Fabio Coelho ; da Nóbrega, Armi Wanderley ; Morelli Cardoso, Maria Helena Wohlers ; Bastos, Lucia Helena Pinto ; Rocha, Leandro Machado

Over the past two decades, concerns have arisen about the efficacy and safety of medicinal plants, highlighting good agricultural practices and quality control. This study aimed to validate a multi-residue analysis method for detecting 268 pesticides in Mikania glomerata tincture, using direct injection and UPLC-MS/MS, per SANTE guidelines. The validation of the method involved evaluating the linearity of analytical curves in terms of the determination coefficient r2 and residuals (%), as well as the limits of quantification (LOQ), matrix effects, precision (expressed as the coefficient of variation, CV), and accuracy (determined as the recovery percentage). The parameters and acceptance criteria were assessed based on SANTE guidelines. The method was then applied to analyse commercial samples of M. glomerata tincture, and traces of carbendazim and dimethomorph were detected. This study underscores the need for regulatory measures to enhance agricultural practices, thereby ensuring the safety and efficacy of medicinal plants.

100 Deals associated with Carbendazim

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Carbendazim	-	DB13009

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
HIV Infections	Phase 1	-	ImQuest BioSciences, Inc.	-
HIV Infections	Phase 1	US	Arisyn Therapeutics Inc	-
HIV Infections	Phase 1	-	Procter & Gamble Co.	-
Neoplasms	Phase 1	US	Arisyn Therapeutics Inc	-