Last update 01 Nov 2024

Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)

Overview

Basic Info

Drug Type
CAR-T
Synonyms-
Target
CLDN18.2 x PDL1
Mechanism
CLDN18.2 modulators(Claudin 18.2 modulators), PDL1 modulators(Programmed death-ligand 1 modulators), Immunologic cytotoxicity
+ [1]
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmCLDN18.2 positive Solid Tumors
Inactive Indication-
Originator Organization
Sichuan UniversitySichuan University
Active Organization
Sichuan UniversitySichuan University
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)
NCT06084286 / Not yet recruitingPhase 1IIT
A Phase I, Open-label, Single-arm, Dose-escalation and Expansion Study of Specific Dual-targeting CLDN18.2 and PD-L1 CAR-T for Patients With CLDN18.2-positive Advanced Solid Tumors
100 Clinical Results associated with Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)
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100 Translational Medicine associated with Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)
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100 Patents (Medical) associated with Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)
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100 Deals associated with Dual-targeting CLDN18.2 and PD-L1 CAR-T cells(Sichuan University)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
CN
Sichuan UniversitySichuan University
30 Oct 2023
CLDN18.2 positive Solid TumorsPhase 1
CN
Sichuan UniversitySichuan University
30 Oct 2023
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Clinical Result

Indication
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Regulation

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