Last update 22 Nov 2024

LY-3849891

Overview

Basic Info

Drug Type
siRNA
Synonyms
PNPLA3 siRNA, LY 3849891, LY3849891
Target
PNPLA3
Mechanism
PNPLA3 modulators(1-acylglycerol-3-phosphate O-acyltransferase modulators), RNA interference
Therapeutic Areas
Digestive System Disorders
Active Indication
Metabolic dysfunction-associated steatotic liver disease
Inactive Indication-
Originator Organization
Dicerna Pharmaceuticals, Inc.Dicerna Pharmaceuticals, Inc.
Active Organization
Eli Lilly & Co.Eli Lilly & Co.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with LY-3849891
NCT05395481 / RecruitingPhase 1
A Single-Ascending and Repeated Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3849891 in Participants With Nonalcoholic Fatty Liver Disease Who Have the PNPLA3 I148M Genotype
100 Clinical Results associated with LY-3849891
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100 Translational Medicine associated with LY-3849891
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100 Patents (Medical) associated with LY-3849891
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100 Deals associated with LY-3849891
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metabolic dysfunction-associated steatotic liver diseasePhase 1
US
Eli Lilly & Co.Eli Lilly & Co.
08 Jun 2022
Metabolic dysfunction-associated steatotic liver diseasePhase 1
JP
Eli Lilly & Co.Eli Lilly & Co.
08 Jun 2022
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Clinical Result

Indication
Phase
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Approval

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Regulation

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