Last update 20 Mar 2025

BMS-986453

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Target
BCMA x GPRC5D
Action
modulators
Mechanism
BCMA modulators(B-cell maturation protein modulators), GPRC5D modulators(G-protein coupled receptor family C group 5member D modulators)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]
Active Indication
Relapse multiple myeloma
Inactive Indication-
Originator Organization
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
Active Organization
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Related

2
Clinical Trials associated with BMS-986453
CTIS2023-506003-26-00
/ RecruitingPhase 1
- CA1190002
NCT06153251
/ RecruitingPhase 1
A Phase 1, Open-Label, Dose-Finding Study of BMS-986453, Dual Targeting BCMAxGPRC5D Chimeric Antigen Receptor T Cells, in Participants With Relapsed and/or Refractory Multiple Myeloma
100 Clinical Results associated with BMS-986453
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100 Translational Medicine associated with BMS-986453
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100 Patents (Medical) associated with BMS-986453
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100 Deals associated with BMS-986453
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapse multiple myelomaPhase 1
Spain
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
23 Jan 2024
Relapse multiple myelomaPhase 1
France
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
23 Jan 2024
Relapse multiple myelomaPhase 1
United States
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
23 Jan 2024
Relapse multiple myelomaPhase 1
Germany
Juno Therapeutics, Inc.Juno Therapeutics, Inc.
23 Jan 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Clinical Trial

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Approval

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Regulation

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