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Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

methylfurfural derivatives (YD Life Science)

Target

Sodium channels

Action

blockers

Mechanism

Sodium channels blockers

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication-

Inactive Indication

Neuralgia

Originator Organization

YD Global Life Science, Inc.

Active Organization-

Inactive Organization

Hallym University

YD Global Life Science, Inc.

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Furfural and methylfurfural are dietary mutagens and are present in various food products and beverages. The alkaline-induced unwinding of calf thymus DNA permitted the measurement of the number of strand breaks formed by furfural and methylfurfural, as a function of reaction time with these mutagenic agents. At the fixed DNA bp/mutagens molar ratio of 1:4, furfural treatment resulted in the formation of almost three times as many strand breaks at the end of 16 h reaction. In the presence of 0.2 M NaCl, a 60% reduction in strand breaks occurred in the case of furfural but only 25% with methylfurfural. It is also found that only in the case of methylfurfural treatment did depurination lead to the degradation of DNA, possibly through the alkylation of DNA bases and phosphates. These results suggest that furfural and methylfurfural may act on DNA by different reaction mechanisms.

01 Jan 1991·Food and Chemical ToxicologyQ2 · MEDICINE

Reaction of furfural and methylfurfural with DNA: Use of single-strand-specific nucleases

Q2 · MEDICINE

Article

Author: A Rahman ; Shahabuddin ; S M Hadi

The furans, furfural and methylfurfural, are dietary mutagens that are present in various food products and beverages. AT base-pair-depleted calf thymus DNA was prepared by the action of pea seed single-strand-specific nuclease on native DNA. Compared with furan-treated native DNA, furan-treated AT-depleted DNA showed a reduced rate of S1 nuclease hydrolysis and a reduced formation of single-strand breaks, as determined using an alkaline unwinding assay. These results indicate that furfural and methylfurfural primarily react with AT base pairs in duplex DNA, and demonstrate the usefulness of single-strand-specific nucleases in such studies.

100 Deals associated with YD-307

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