100 Clinical Results associated with Etofesalamide
100 Translational Medicine associated with Etofesalamide
100 Patents (Medical) associated with Etofesalamide
1
Literatures (Medical) associated with Etofesalamide01 Jul 2005·Acta pharmacologica SinicaQ1 · MEDICINE
Phase II metabolites of etofesalamide in filamentous fungi1
Q1 · MEDICINE
Article
Author: Da-fang Zhong ; Qiang Li ; Gui-lei Ma ; Hai-hua Huang ; Yu-ming Sun
AIM:To study phase II metabolites of etofesalamide in filamentous fungi.
METHODS:Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure.
RESULTS:Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected.
CONCLUSION:Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals.
100 Deals associated with Etofesalamide