Author: Li, Pingping ; Ma, Xingyu ; Wu, Boji ; Zhang, Jiawen ; Pan, Lina ; Zhang, Jihang ; He, Jingyu ; Liu, Chuan ; Qin, Zhexue ; Hu, Houyuan ; Wang, Xuhong ; Ning, Ke ; Bian, Shizhu ; He, Yi ; Tang, Heng

Scutellarein (Sc), a natural flavonoid, holds potential for treating pulmonary arterial hypertension (PAH), yet its mechanisms remain unexplored. This study investigated Sc's therapeutic effects and underlying pathways in PAH. In vivo experiments demonstrated that Sc significantly attenuated right ventricular hypertension, pulmonary arterial remodeling, αSMA expression, and vascular inflammation in PAH models. In vitro, Sc suppressed hypoxia-induced proliferation, migration, inflammation, and pyroptosis in human pulmonary artery smooth muscle cells (HPASMCs). Mechanistically, Sc activated the SIRT1/NAD⁺ axis to restore mitochondrial homeostasis: it upregulated SIRT1 expression and elevated NAD⁺ levels by promoting SIRT1-mediated deacetylation of nicotinamide nucleotide transhydrogenase (NNT), thereby enhancing NNT activity. Elevated NAD⁺ further activated SIRT1, forming a self-reinforcing SIRT1/NNT/NAD⁺ feedback loop that mitigated hypoxia-induced mitochondrial dysfunction. This study identifies Sc as a novel regulator of the SIRT1-dependent NNT deacetylation pathway, which stabilizes NAD⁺ homeostasis to counteract HPASMCs dysregulation in PAH. These findings highlight Sc's potential as a therapeutic candidate for PAH, offering insights into targeting mitochondrial-metabolic pathways for vascular remodeling diseases.

01 Jun 2025·Current Pharmaceutical Design

Therapeutic Role of Scutellarein in Neurological Disorders

Article

Author: Shukla, Rahul ; Kumar, Rohit ; Bai, Sucharitha ; Naqvi, Saba

Scutellarein, a flavone found in the perennial herb Scutellaria baicalensis, has a wide range of pharmacological actions, such as antioxidant, anti-inflammatory, and neuroprotective. Increasing evidence has emphasized the developing significance of scutellarein in several neurological illnesses, such as Alzheimer's and Parkinson's disease, cerebral ischemia, and neuroblastoma. This review is centered on the molecular processes that underlie the neuroprotective properties of scutellarein in various neurological disorders, as indicated by recent pre-clinical research. Furthermore, it critically examines the potential challenges and advantages of scutellarein inclusion within the range of treatments for neurological disorders.

01 May 2025·Food Chemistry

A design of Tetrastigma hemsleyanum's flavonoid loaded polyvinylpyrrolidone nanoparticles for improving its bioavailability and biological activities

Article

Author: Li, Dongbin ; Ruan, Xiao ; Zheng, Shaojian ; Xu, Fengjiao ; Yang, Li ; Yu, Minfen ; Wang, Qiang ; Qu, Aili

Flavonoids in plant extracts exhibit significant biological activities but are limited by their low bioavailability. This research aimed to improve the functional properties by synthesizing polyvinylpyrrolidone (PVP) nanoparticles using flavonoids derived from T. hemsleyanum. 208 flavonoids were identified using ultrahigh-performance-mass/mass spectrometry and used for nanoparticle preparation. The nanoparticles exhibited 24 % and 55 % higher equilibrium dissolution rates in simulated intestinal and gastric fluids than free flavonoids. With spherical morphologies, 100 nm size and - 26.7 mV zeta potential, these nanoparticles showed remarkable improvements in biological activities, including 1.5-fold enhancement in antioxidant capacity, HeLa cell inhibition, and antimicrobial efficacy, and a 5-fold increase in anti-inflammatory effects compared to unencapsulated flavonoids. This research has established a methodological system that could effectively enhance the utilization rate of flavonoids in plant extracts, offering promising potential for application in functional foods.

100 Deals associated with Scutellarein

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Severe Acute Respiratory Syndrome	Preclinical	South Korea	Kookmin University	01 Jun 2012

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Scutellarein

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation