sAJM589

A rapid, efficient and environmentally benign procedure for the synthesis of novel heteroaryl-substituted dihydrobenzo[a]pyrimido[5',4':5,6]pyrido[2,3-c]phenazines were developed via condensation/Knoevenagel/Michael/heterocyclization reactions of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aromatic aldehydes and 6-amino-1,3-dimethyluracil in the presence of H₃PW₁₂O₄₀@nano-ZnO as a recyclable heterogeneous catalyst in aqueous medium under microwave irradiationThis sequential green processed with main aspects such as: operational simplicity, high yields, low cost, easy handling, eco-friendly and reusability of the catalyst, absence of any tedious workup or purification and avoidance of hazardous or toxic reagents/catalysts/solvents opened an effective and convenient way to pyrimido-functionalized benzophenazine systems, which were promising compounds for different biomedical applications.