Last update 26 Dec 2024

NT-112

Overview

Basic Info

Drug Type
TCR therapy
Synonyms
NT 112
Target
KRAS G12D
Mechanism
KRAS G12D inhibitors(GTPase KRas G12D inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease+ [2]
Active Indication
Adenocarcinoma of large intestineEndometrial CarcinomaNon-Small Cell Lung Cancer+ [2]
Inactive Indication-
Originator Organization
Neogene Therapeutics, Inc.Neogene Therapeutics, Inc.Startup
Active Organization
AstraZeneca PLCAstraZeneca PLCNeogene Therapeutics, Inc.Neogene Therapeutics, Inc.Startup
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with NT-112
NCT06218914 / RecruitingPhase 1
An Open-label, Phase 1, Multicenter Study to Evaluate the Safety and Preliminary Anti-tumor Activity of NT-112 in Human Leukocyte Antigen-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for the KRAS G12D Mutation
100 Clinical Results associated with NT-112
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100 Translational Medicine associated with NT-112
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100 Patents (Medical) associated with NT-112
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100 Deals associated with NT-112
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenocarcinoma of large intestinePhase 1
US
AstraZeneca PLCAstraZeneca PLC
05 Feb 2024
Endometrial CarcinomaPhase 1
US
AstraZeneca PLCAstraZeneca PLC
05 Feb 2024
Non-Small Cell Lung CancerPhase 1
US
AstraZeneca PLCAstraZeneca PLC
05 Feb 2024
Pancreatic Ductal AdenocarcinomaPhase 1
US
AstraZeneca PLCAstraZeneca PLC
05 Feb 2024
Solid tumorPreclinical
NL
Neogene Therapeutics, Inc.Neogene Therapeutics, Inc.Startup
27 Jul 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Approval

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Regulation

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