A Phase 1, Multiple Dose, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Examining the Effects of CXB722 in Mitigating Neuroendocrine Stress Response in Healthy Males

The purpose of this study is to assess the effects of CXB722 on neuroendocrine stress response and subjective reports related to mood and stress during and after experimentally induced stress among healthy young males.

Start Date01 Dec 2008

Sponsor / Collaborator

CeNeRx BioPharma, Inc.

100 Clinical Results associated with Pivagabine

100 Translational Medicine associated with Pivagabine

100 Patents (Medical) associated with Pivagabine

Literatures (Medical) associated with Pivagabine

16 Dec 2024·Chemical Research in Toxicology

Melatonin Vapes Contain Potential Contaminants and Alter the Human Bronchial Epithelial Transcriptome

Article

Author: Ehrmann, Brandie M. ; Esther, Charles R. ; Love, Charlotte A. ; Schichlein, Kevin D. ; Porter, Ned A. ; Rebuli, Meghan E. ; Clapp, Phillip W. ; Kim, Hye-Young H. ; Guhr Lee, Tara N. ; Jaspers, Ilona

Melatonin vaping products, touted for their faster absorption than oral melatonin supplements, have been gaining popularity among adolescents as sleep aid. Here, we elucidated the response of human bronchial epithelial cells (hBECs) to high levels of melatonin from vaped aerosols, investigated the uptake of melatonin by hBECs in vitro, and characterized the chemical composition of three commercially available melatonin vapes. Melatonin vape exposure decreased the secretion of chemokines and produced an immunosuppressive gene expression signature. The tested devices contained potential contaminants, including pharmaceuticals and industrial chemicals. Further investigation is needed for melatonin vapes to determine their local and systemic toxicity.

01 Apr 2024·Plant and Soil

Correction to: Melatonin enhances the tolerance of apple seedlings to salt stress by regulating the microbial community structure and metabolite composition of the rhizosphere

Author: Du, Peihua ; Yin, Baoying ; Ma, Changqing ; Zhou, Shasha ; Zhang, Xueying ; Cao, Yang ; Shang, Yuwei ; Li, Zhongyong ; Xu, Jizhong ; Liang, Bowen

The potential roles of melatonin (MT) in alleviating salt stress in apple plants (Malus hupehensis) are not understood.We conducted pot experiments in which such plants were exposed to either 0 or 200 mmol/L NaCl together with 100 μmol/L MT.MT enhanced salt stress tolerance through activation of the antioxidant system and regulation of Na+ and K+ balance, which restored plant growth.We used high-throughput sequencing and metabolomics methods to investigate the effects of MT on the microbial community structure and metabolite composition of the rhizosphere.Exogenous MT significantly altered the community structure of bacteria and fungi and increased cooperation among microbial communities.In addition, the communities were enriched with microbes in the genera Thauera, Nocardioides, Desulfuromonas, Amaricoccus, and Microascus, potentially beneficial microorganisms regulated by MT.Exogenous MT also altered the metabolite composition of the soil and increased the relative abundance of beneficial metabolites.Importantly, Spearman correlation anal. revealed that potentially beneficial microorganisms appeared to be recruited by the exudation of (2S)-3-hydroxy-1,2-propanediyl dibutanoate.Our results show that MT effectively reduce ROS, regulate Na+ and K+ balance, and regulate specific microbial communities and metabolites, thus alleviating the inhibitory effects of salt stress.These results improve our understanding of the mechanisms by which MT alleviates salt stress in plants.

24 May 2023·Journal of the American Chemical Society

Photo- and Metal-Mediated Deconstructive Approaches to Cyclic Aliphatic Amine Diversification

Article

Author: Sarpong, Richmond ; Ruble, J. Craig ; Musaev, Djamaladdin G. ; Shi, Yuan ; Payer, Stefan ; Park, Bohyun ; Rackl, Jonas W. ; Kaledin, Alexey L. ; Roque, Jose B. ; Soro, David M. ; Baik, Mu-Hyun

Described herein are studies toward the core modification of cyclic aliphatic amines using either a riboflavin/photo-irradiation approach or Cu(I) and Ag(I) to mediate the process. Structural remodeling of cyclic amines is explored through oxidative C-N and C-C bond cleavage using peroxydisulfate (persulfate) as an oxidant. Ring-opening reactions to access linear aldehydes or carboxylic acids with flavin-derived photocatalysis or Cu salts, respectively, are demonstrated. A complementary ring-opening process mediated by Ag(I) facilitates decarboxylative Csp³-Csp² coupling in Minisci-type reactions through a key alkyl radical intermediate. Heterocycle interconversion is demonstrated through the transformation of N-acyl cyclic amines to oxazines using Cu(II) oxidation of the alkyl radical. These transformations are investigated by computation to inform the proposed mechanistic pathways. Computational studies indicate that persulfate mediates oxidation of cyclic amines with concomitant reduction of riboflavin. Persulfate is subsequently reduced by formal hydride transfer from the reduced riboflavin catalyst. Oxidation of the cyclic aliphatic amines with a Cu(I) salt is proposed to be initiated by homolysis of the peroxy bond of persulfate followed by α-HAT from the cyclic amine and radical recombination to form an α-sulfate adduct, which is hydrolyzed to the hemiaminal. Investigation of the pathway to form oxazines indicates a kinetic preference for cyclization over more typical elimination pathways to form olefins through Cu(II) oxidation of alkyl radicals.

100 Deals associated with Pivagabine

External Link

KEGG	Wiki	ATC	Drug Bank
D07342	Pivagabine	N06AX15	DB12951

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Anxiety Disorders	Phase 2	-	CeNeRx BioPharma, Inc.	-
Anxiety Disorders	Phase 2	United States	CeNeRx BioPharma, Inc.	-
Depressive Disorder	Phase 2	United States	CeNeRx BioPharma, Inc.	-
Stress, Psychological	Phase 2	United States	CeNeRx BioPharma, Inc.	-

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