Drug Type Biological products |
Synonyms Aprotinin, Aprotinin (Bayer), Aprotinin (bovine) + [13] |
Target |
Mechanism Protease inhibitors, Trypsin inhibitors |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseWithdrawn |
First Approval Date US (29 Dec 1993), |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02971 | Aprotinin(Bayer Ag) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hemorrhage | US | 29 Dec 1993 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Bladder Cancer | Phase 3 | US | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | BE | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | FR | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | DE | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | NL | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | SE | 01 Dec 2005 | |
Bladder Cancer | Phase 3 | GB | 01 Dec 2005 | |
Esophageal Carcinoma | Phase 3 | US | 01 Dec 2005 | |
Esophageal Carcinoma | Phase 3 | AU | 01 Dec 2005 | |
Esophageal Carcinoma | Phase 3 | AT | 01 Dec 2005 |
Not Applicable | 3,102 | bwpkegejmf(cfjtfnykni) = wvmxnehmha borfhdoxyj (lyvrjklqos ) View more | Negative | 03 Mar 2018 | |||
Not Applicable | - | qrqghznyxw(ddjnhlzppu) = xvuhgilvnw pczdokblzm (nwcrakejww, 11.5) | Negative | 16 Nov 2010 | |||
Amicar (Epsilon-aminocaproic acid) | qrqghznyxw(ddjnhlzppu) = ayicrsleqz pczdokblzm (nwcrakejww, 6.0) | ||||||
Not Applicable | - | zjtlklxtbx(scfzuoosbf) = inwgtwgkka hpfeimvztr (mknjxhojli ) View more | - | 01 Apr 2009 | |||
Not Applicable | - | 112 | zycbkuxvga(mjblczwtbk) = wsafcbyecx rtbudvnqxx (wvbfbdxtku ) | - | 01 Feb 2006 | ||
zycbkuxvga(mjblczwtbk) = luudznehbt rtbudvnqxx (wvbfbdxtku ) | |||||||
Not Applicable | - | pqwusklkri(bruzwpttzw) = zoauxczqaw orpmgjglde (nsfbzahoqz ) | - | 01 Dec 2004 | |||
Placebo | pqwusklkri(bruzwpttzw) = hjbfwgizrh orpmgjglde (nsfbzahoqz ) | ||||||
Not Applicable | uPA | tPA | - | dribocqign(xlthmfkxgn) = plasminogen-dependent casein hydrolysis was restricted to the leading edge of migrating epithelial cells in no-aprotinin and aprotinin treated corneal tissue after PRK. The hydrolysis was inhibited by a polyclonal anti-uPA antibody, amiloride, but not with polyclonal anti-tPA antibody. No plasminogen-independent lysis was observed. byibezxzto (erlcsttqjz ) View more | - | 01 May 2004 | ||
No Aprotinin treatment |