Morbidity and mortality in patients suffering from systemic inflammatory response syndrome (SIRS) remain high. The primary aim of the present study is to assess the efficacy of a standardized 5% serum-protein solution containing immunoglobulins on serum cytokine levels. The secondary aim is to evaluate survival of the patients.

Start Date01 Jul 1996

Sponsor / Collaborator

Medical University of Vienna

100 Clinical Results associated with Biseko

100 Translational Medicine associated with Biseko

100 Patents (Medical) associated with Biseko

Literatures (Medical) associated with Biseko

01 Mar 2012·Basic & Clinical Pharmacology & ToxicologyQ3 · MEDICINE

Prolonged Antispasmodic Effect in Isolated Radial Artery Graft and Pronounced Platelet Inhibition Induced by the Inodilator Drug, Levosimendan

Q3 · MEDICINE

Article

Author: Attila Kun ; János Pataricza ; Nóra Ambrus ; J. Gyula Papp ; Piero Pollesello ; András Varró ; Jeno A. Szolnoky

Abstract: Radial artery frequently develops spasm and requires vasodilator therapy during coronary artery bypass graft surgery (CABG). Levosimendan was recently shown to oppose 5‐hydroxytryptamine‐induced contraction of radial artery (RA) grafts. The aim of the present study was to explore whether levosimendan retains its vasodilatory capacity following in vitro pre‐incubation of RA segments with the inodilator. A possible cumulative effect of the drug in human platelets was also studied. Human isolated RA segments were pre‐incubated in 0.16 μmol/L levosimendan containing solution or in 0.9% NaCl, Bretschneider, 5% albumin and a 5% human serum protein solution (Biseko) as controls for 45 min. Contractions were induced by three consecutive administrations of 5‐hydroxytryptamine (0.31 μM) 45, 90 and 120 min. after exchanging the pre‐incubation solutions with Krebs‐Henseleit solution, uniformly. Receptor‐independent contractions (KCl, 80 mmol/L), endothelium‐dependent (acetylcholine, 1 μmol/L) and independent relaxations (papaverine, 100 μmol/L) were also investigated. Washed human platelets were pre‐incubated with levosimendan (0.06 μmol/L) for 2 or 15 min. and aggregated with thrombin (0.1 IU/mL). Contractions of RA grafts induced by 5‐hydroxytryptamine were significantly smaller 45 min. and 90 min. after the replacement of levosimendan with Krebs‐Henseleit solution. Biseko solution also decreased the contraction of the graft at 45 min. Contractions did not change in time following the pre‐incubations of radial arteries with 0.9% NaCl, Bretschneider and 5% albumin solutions. The grafts remained intact as assessed by their maximum contractions and endothelium‐dependent and endothelium‐independent relaxations at the end of the investigations. Platelets revealed larger anti‐aggregatory effect to levosimendan following the enhancement of the incubation time. Results indicate that the antispasmodic and anti‐aggregatory effects of levosimendan cumulate in the vascular tissue and in platelets. The storage of RA with the inodilator before implantation may help to prevent the intraoperative spasm of the graft and also thrombotic occlusion during CABG surgery.

29 Sep 2009·Eplasty

A qualitative and quantitative analysis of protein substitution in human burn wounds.

Article

Author: Steinau, Hans-Ulrich ; Joneidi-Jafari, Hamid ; Klatte, Walter ; Lehnhardt, Marcus ; Daigeler, Adrien ; Hauser, Joerg ; Fischer, Ulrich

OBJECTIVEIn major burn wounds of more than 15% total burn surface area mediator-associated reactions lead to capillary leak resulting in critical condition. Little is known about the efficiency of protein substitution. We quantified and qualified the systemic and local protein loss in burn patients during protein substitution, comparing fresh frozen plasma and the human serum protein solution Biseko.METHODSIn 40 patients suffering from second-degree burn wounds with the total burn surface area between 20% and 60%, immediately after admission a defined wound surface area was enclosed with in a wound chamber. Wound fluid and serum samples were collected in 8 hour intervals for 2 days. Samples were analyzed for total protein, albumin, immunoglobulins -A, -G, -M, clotting parameters, c-reactive protein, and white blood cells. Protein substitution started 24 hour posttrauma. In a randomized pattern, patients received equal volumes of fresh frozen plasma or Biseko.RESULTSTotal protein and albumin accumulated in high concentrations in wound fluid. With beginning of fresh frozen plasma substitution on day 2 posttrauma, serum total protein (1.7 g-3.9 g) and albumin (1.3 g-3.4 g) concentrations increased. Substitution of Biseko resulted in a stronger increase (serum total protein 1.8 g to 4.5 g, albumin 0.9 g to 3.4 g). Wound fluid concentrations revealed similar change patterns. Immunoglobulins showed higher serum levels in the Biseko group. C-reactive protein and white blood cell values indicated a lower immunological reaction in the Biseko group.CONCLUSIONSSubstitution of human protein solutions such as Biseko can result in significantly higher serum protein and albumin concentrations as well as lower infection parameters. Higher serum immunoglobulins could help to decrease potential immunodeficiency.

01 Jul 2009·European Journal of Cardio-Thoracic SurgeryQ2 · MEDICINE

Biseko® colloidal solution diminishes the vasoreactivity of human isolated radial arteries☆

Q2 · MEDICINE

Article

Author: András Varró ; Antal Szabó-Biczók ; János Pataricza ; Nóra Ambrus ; Jeno Szolnoky ; Julius Gy-Y. Papp ; Gábor Bogáts

OBJECTIVERadial arteries are increasingly used as grafts in coronary artery bypass surgery. The surgical preparation and intraoperative management of this conduit artery may affect its early and long-term patencies. We investigated the effects of the colloidal Biseko and 5% albumin solutions as well as the crystalloid physiological saline (0.9% NaCl) and Bretschneider solutions on the contractile and relaxing capacities of isolated human radial artery grafts.METHODRadial artery segments were harvested using the technique with an ultrasonic scalpel, and 2.5-3mm rings were obtained from the proximal part of the artery. Arterial rings were stored in Biseko or 5% albumin solutions and in 0.9% NaCl or Bretschneider solutions for 45 min. Isometric tensions of radial arteries obtained from 26 patients were measured in isolated organ baths. Contractions were induced by 0.31 micromolL(-1) 5-hydroxytryptamine and 10 micromol L(-1) noradrenaline. Endothelium-dependent relaxations were induced by 10 micromol L(-1) acetylcholine and 1 micromol L(-1) bradykinin as well as the endothelium-independent relaxations by 10 micromol L(-1) glyceryl trinitrate and 100 micromol/l papaverine.RESULTSContractions of radial arteries induced by 5-hydroxytryptamine were significantly lower following storage in Biseko solution (12.6+/-4.4 mN) than in 5% albumin (37.9+/-13.0 mN, p=0.03) or in 0.9% NaCl solution (35.9+/-11.9 mN, p=0.04). Noradrenaline-induced contractions of the arteries were also diminished in Biseko solution compared to those stored in 5% albumin (32.9+/-6.2 mN vs 49.2+/-6.4 mN, p=0.01). No significant differences in relaxations were obtained between the two crystalloid and the two colloidal solutions using endothelium-dependent and independent vasorelaxants.CONCLUSIONOur results suggest that storage of radial artery in Biseko colloidal solution before coronary artery bypass grafting decreases the sensitivity of the graft to vasoconstriction, thereby decreasing the risk of intra/perioperative graft failure.

100 Deals associated with Biseko

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Indication	Country/Location	Organization	Date
Hypovolemia	-	Biotest AG	01 Jan 1949

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