Prusogliptin/Metformin

Main objectives: The first part evaluates the bioequivalence of a single oral administration of plutagliptin metformin extended-release fixed-dose combination tablets and a combined administration of plutagliptin tablets and metformin hydrochloride extended-release tablets in healthy subjects in the fed state; the second part evaluates the effect of food on the pharmacokinetics of plutagliptin and metformin hydrochloride after a single oral administration of plutagliptin metformin extended-release fixed-dose combination tablets in healthy subjects. Secondary objectives: To evaluate the safety of the test preparation and the reference preparation after a single oral administration in healthy subjects.