A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study

This is a two-part trial assessing the effects of MENT on blood pressure. The first part of the trial is an open-label pilot study to verify the MENT gel formulation delivers appropriate drug levels. Upon confirming MENT serum levels are within the required range, clinical trial material will be produced and labeled. Consequently, the second part of the trial, the main study, will proceed approximately two months after the conclusion of the pilot study. The main study, is a randomized, double-blind, placebo-controlled study.

Start Date01 Dec 2008

Sponsor / Collaborator

The Population Council, Inc.

100 Clinical Results associated with 7-Alpha-Methyl-19-Nortestosterone

100 Translational Medicine associated with 7-Alpha-Methyl-19-Nortestosterone

100 Patents (Medical) associated with 7-Alpha-Methyl-19-Nortestosterone

192

Literatures (Medical) associated with 7-Alpha-Methyl-19-Nortestosterone

11 Dec 2023·Biology of reproduction

Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

Article

Author: Brown, Jill E ; Nguyen, Donna ; Kim, Kyuri ; Furimsky, Anna M ; Lee, Min S ; Kroopnick, Jeffrey M ; Parman, Toufan ; Gupta, Pranab ; Blithe, Diana L ; Rausch, Linda ; Bunin, Deborah I ; Lin, Ming-Teh

Abstract:

Male contraceptive development has included use of testosterone (T) with or without a progestin or the use of a single molecule such as progestogenic androgens (PA) for suppression of testicular T production. Expanding upon the vast amount of data accumulated from nortestosterone (NT), NT analogs, and their prodrugs, a new series of PA, the C7 methyl, and ethyl α-substituted T analogs 7α-Methyltestosterone (7α-MT) and 7α-Ethyltestosterone (7α-ET), respectively, were hypothesized and designed to have superior androgenic and progestogenic activities when compared with parent T. Results from androgen receptor and progesterone receptor competitive binding and transcriptional activation assays showed favorable activities for these T analogs. Additionally, 7α-MT and 7α-ET were shown to be active substrates for aromatase in vitro, mitigating a potential negative impact on bone mineral density with long-term use. In conjunction with this observation, the diminished metabolism of these T analogs by 5α-reductase may reduce potential concerns for prostatic growth. In the Hershberger in vivo rat bioassay, 7α-MT and 7α-ET showed superior androgenic and anabolic activities as compared with T. These C7 α-substituted T analogs also showed clear progestogenic activity in the McPhail bioassay which evaluated endometrial glandular arborization in a rabbit model. The discovery of aromatizable molecules with reduced metabolism by 5α-reductase that have androgenic, anabolic, and progestogenic properties indicates that the core and/or prodrugs of 7α-MT and 7α-ET are promising molecules for further development as male contraceptive PAs.

01 Oct 2023·Nutrition (Burbank, Los Angeles County, Calif.)

Effect of the ketogenic diet on gut microbiome composition and metabolomics in polycystic ovarian syndrome rats induced by letrozole and a high-fat diet.

Article

Author: Ren, Ning ; Chen, Yun ; Zhao, Ying ; Fang, Xiaohong ; Cheng, Wei ; Wang, Ruye ; Zhang, Qin ; Miao, Chenyun

OBJECTIVES:

The ketogenic diet (KD) is recommended to improve polycystic ovary syndrome (PCOS); however, its mechanisms of action are unclear. We aimed to study the effects and mechanisms of action of the KD on the gut microbiome and metabolites in PCOS rats and determine whether the sex hormone regulatory effects are related to modulations of the gut microbiota and metabolites.

METHODS:

PCOS was induced with a high-fat diet and letrozole in the rats. A KD was fed to rats for 8 wk, serum samples were collected for biochemical analysis, and the rats' fecal samples were subjected to 16S ribosomal RNA sequencing and metabolomic analysis.

RESULTS:

Feeding with a KD for 8 wk suppressed body weight gain, decreased luteinizing hormone and androgen levels, and improved insulin levels. Furthermore, the KD reversed the dysregulation of the gut microbiota in PCOS rats by adjusting the ratio of firmicutes and bacteroidetes. Also, the KD was involved in hormonal metabolic pathways by reducing the levels of some metabolites (such as testosterone and 7α-hydroxytestosterone) that are closely related to gut microbes.

CONCLUSIONS:

The KD improved the clinical phenotype and insulin resistance in PCOS rats and altered the composition of the gut microbiome and metabolites, which were associated with androgen metabolism, representing a potential mechanism for mediating the effects of the KD on sex hormone metabolism in PCOS. However, our study found contradictory effects of KD on the gut microbiome in PCOS, which need further research.

01 Sep 2022·Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Bisphenol F blocks Leydig cell maturation and steroidogenesis in pubertal male rats through suppressing androgen receptor signaling and activating G-protein coupled estrogen receptor 1 (GPER1) signaling

Article

Author: Zhu, Yang ; Tian, Fuhong ; Ge, Ren-Shan ; Li, Huitao ; Li, Qiyao ; Shi, Mengna ; Li, Jingjing ; Shi, Lei

Bisphenol F (BPF) is a new analog of bisphenol A (BPA). BPA has deleterious effects on the male reproductive system, but the effect of BPF has not been studied in detail. In this study we focus on the effect of BPF on Leydig cell maturation. Male Sprague-Dawley rats were gavaged with 0, 1, 10, or 100 mg/kg BPF from postnatal days 35-56. BPF significantly reduced serum testosterone levels and sperm count in cauda epididymis at dose ≥1 mg/kg. It significantly down-regulated the expression of steroidogenic enzymes, while increasing FSHR and SOX9 levels at 10 and 100 mg/kg. Further studies showed that BPF reduced NR3C4 expression in Leydig and Sertoli cells without affecting its levels in peritubular myoid cells. BPF markedly increased GPER1 in Leydig cells at 100 mg/kg, and it significantly reduced SIRT1 and PGC1α levels in the testes at 100 mg/kg. BPF significantly inhibited testosterone production by immature Leydig cells at 50 μM after 24 h of treatment, which was completely reversed by NR3C4 agonist 7α-methyl-19-nortestosterone and partially reversed by GPER1 antagonist G15 not by ESR1 antagonist ICI 182,780. In conclusion, BPF negatively affects Leydig cell maturation in pubertal male rats through NR3C4 antagonism and GPER1 agonism.

News (Medical) associated with 7-Alpha-Methyl-19-Nortestosterone

23 Jun 2021

·www.coatingsworld.com

The Shepherd Color Company Launches New IR Reflective Green Pigment

Breaking News The Shepherd Color Company Launches New IR Reflective Green Pigment Chromium Oxide Green, also known as C.I. Pigment Green 17, is widely used in high-performance color matches and has wide regulatory approvals. Shepherd Color has more than 90 years of experience developing, optimizing, and manu-facturing its range of complex inorganic color pigments. This addition to their specialty performance Dynamix easily-dispersed and Arctic IR Reflective pigment lines, adds yet another pigment to their extensive color options. Chromium Oxide Green, also known as C.I. Pigment Green 17, is widely used in high-performance color matches and has wide regulatory approvals and inclusion in chemical registries around the world. Green 30C659 is an addition to the Arctic IR Reflective line of pigments which have become the standard for use in “cool coatings” because of their po-tential to reduce energy usage in building products. Shepherd Color’s Green 30C659 incorporates its Dynamix technology, which removes the time consuming, energy-intensive, and variable pigment grinding step in laboratory de-velopment, scale-up and full production. Green 30C659 is all inorganic and doesn’t have any organic dispersion aids or resins in-cluded that might compromise the performance of systems incorporating the pigment. This unique blending of properties makes the pigment a cornerstone of any sustainable coating or plastic system. Common uses for Green 30C659 are high-performance coatings such as coil coating, ex-trusion spray, automotive, industrial, architectural, powder and other coatings. It can also be used in plastics and engineering polymers, especially in thin films and fibers. The pig-ment is optimized for easy dispersion and has the following characteristics: • Dark green color • High Total Solar Reflectance (TSR) • High opacity and heat stability • Compatible with wide range of water and solvent systems and plastics Green 30C659 is a great partner to Shepherd Color’s other innovative Arctic IR Reflective pigments helping customers to expand their inorganic durable and weatherable color space options. Shepherd Color announced the launch of its new specialty Chromium Oxide Green 30C659.Shepherd Color has more than 90 years of experience developing, optimizing, and manu-facturing its range of complex inorganic color pigments. This addition to their specialty performance Dynamix easily-dispersed and Arctic IR Reflective pigment lines, adds yet another pigment to their extensive color options.Chromium Oxide Green, also known as C.I. Pigment Green 17, is widely used in high-performance color matches and has wide regulatory approvals and inclusion in chemical registries around the world. Green 30C659 is an addition to the Arctic IR Reflective line of pigments which have become the standard for use in “cool coatings” because of their po-tential to reduce energy usage in building products.Shepherd Color’s Green 30C659 incorporates its Dynamix technology, which removes the time consuming, energy-intensive, and variable pigment grinding step in laboratory de-velopment, scale-up and full production.Green 30C659 is all inorganic and doesn’t have any organic dispersion aids or resins in-cluded that might compromise the performance of systems incorporating the pigment. This unique blending of properties makes the pigment a cornerstone of any sustainable coating or plastic system.Common uses for Green 30C659 are high-performance coatings such as coil coating, ex-trusion spray, automotive, industrial, architectural, powder and other coatings. It can also be used in plastics and engineering polymers, especially in thin films and fibers. The pig-ment is optimized for easy dispersion and has the following characteristics:• Dark green color• High Total Solar Reflectance (TSR)• High opacity and heat stability• Compatible with wide range of water and solvent systems and plasticsGreen 30C659 is a great partner to Shepherd Color’s other innovative Arctic IR Reflective pigments helping customers to expand their inorganic durable and weatherable color space options.

100 Deals associated with 7-Alpha-Methyl-19-Nortestosterone

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-	7-Alpha-Methyl-19-Nortestosterone	-	DB05830

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