Delving into the Latest Updates on Gamolenic acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(6,9,12)-linolenic acid, (6Z,9Z,12Z)-Octadecatrienoic acid, (Z,Z,Z)-6,9,12-octadecatrienoic acid

+ [16]

Target-

Action

modulators

Mechanism

Immunomodulators

Therapeutic Areas

Immune System DiseasesCongenital DisordersSkin and Musculoskeletal Diseases

Active Indication

Dermatitis, Atopic

Inactive Indication

Breast CancerMastodyniaRheumatoid Arthritis

Originator Organization

Scotia

Active Organization

Scotia

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Australia (15 Jul 1994),

Dermatitis, Atopic

Regulation-

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Structure/Sequence

Molecular FormulaC18H30O2

InChIKeyVZCCETWTMQHEPK-QNEBEIHSSA-N

CAS Registry506-26-3

Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as preventing esophageal stricture after endoscopic submucosal dissection of superficial esophageal neoplasms - The efficacy of shielding method with autologous fibrin glue and polyglycolic acid sheets for the prevention of postoperative stricture after esophageal endoscopic submucosal dissection

Start Date15 May 2017

Sponsor / Collaborator-

100 Clinical Results associated with Gamolenic acid

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100 Translational Medicine associated with Gamolenic acid

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100 Patents (Medical) associated with Gamolenic acid

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15,129

Literatures (Medical) associated with Gamolenic acid

01 Apr 2025·Food Chemistry

Polar lipids and proteins in milk fat globule membranes as players in spontaneous lipolysis in cow’s milk

Article

Author: Hurtaud, C ; Viala, D ; Cebo, C ; Imbert, A ; Bonnet, M ; Bernard, L ; Delosière, M

A study of the lipidome and proteome was performed on milk fat globule membranes (MFGM) originating from milk samples from high (HL) and low (LL) lipolysis groups of cows. Combined univariate and multivariate statistical analyses proposed a set of variables highly associated to contrasted samples with regard to milk lipolysis. Milk from HL group were related to 4 phosphatidylinositols, 8 phosphatidylcholines, 1 sphingomyelin and 27 proteins, among them the phosphatidylcholine/phosphatidylethanolamine ratio and ORM1 may contribute to the membrane remodeling of the MFGM. The abundance of CP, CHI3L1, NECTIN2, A2M were strongly positively correlated with HL. Conversely, 3 phosphatidylinositols, 1 phosphatidylcholine and 2 phosphatidylethanolamines were assigned to the LL group. The HL group in cows is associated with a specific MFGM phospholipids and proteins profile, suggesting an impact on membrane fluidity and lipid rafts composition intervening in LPL anchoring and activation, as well as on pro-inflammatory lipids and proteins.

01 Apr 2025·Aquaculture

Effects of dietary zinc on growth, bone-related genes expression and skeletal anomalies in gilthead seabream (Sparus aurata) larvae

Author: Sivagurunathan, U. ; Dominguez, David ; Tseng, Yiyen ; Izquierdo, Marisol ; Philip, Antony Jesu Prabhu

Zinc (Zn) is one of the essential nutrients required for growth and bone development in all vertebrates.Zn deficiency has been related to demineralization of bones and low growth in fish.The present study was conducted to determine the role of dietary Zn levels on growth, bone mineralization, gene expression and skeletal anomalies during early developmental stages of gilthead seabream (Sparus aurata).For that purpose, larvae were fed with six microdiets containing different levels of Zn: 79, 98, 110, 130, 150, and 248 mg Zn/kg diets, resp.After 16 days of feeding, larvae fed diets with110 and 130 mg Zn/kg showed better growth and mineralization of vertebrae, along with a lower incidence of skeletal anomalies compared to larvae fed with other diets.Moreover, the expression of bmp2, opn and oc was linearly related to mineralization of vertebrae.On the contrary, larvae fed diets non-supplemented with Zn (79 mg Zn/kg diet), showed an increase in the TBARS value, reduced growth, and a high incidence of severe skeletal anomalies denoting a deficiency in Zn.Besides, the highest dietary Zn levels (248 mg Zn/kg diet) also increased TBARS value and reduced larval growth.These results suggested that dietary Zn levels up to 110 mg/kg would be required by seabream larvae (36 dph) to promote growth, bone mineralization, protection from oxidation and prevent the prevalence of skeletal anomalies, whereas symptoms of Zn deficiency and excess were resp. found at 79 and 248 mg Zn/kg diet.

01 Mar 2025·Lipids

Association of erythrocyte fatty acid compositions with the risk of pancreatic cancer: A case–control study

Article

Author: Yu, Le ; Wang, Yongjin ; Zhang, Hui ; Shehzad, Qayyum ; Wang, Xingguo ; Yin, Hongming ; Xiao, Feng ; Wu, Gangcheng ; Jin, Qingzhe ; Wang, Yandan

AbstractPancreatic cancer (PC) is one of the most fatal malignancies, which has attracted scientists to investigate its etiology and pathogenesis. Nevertheless, the association between erythrocyte fatty acids and PC risk remains unclear. This study aimed to evaluate the association between levels of erythrocyte fatty acids and PC risk. The erythrocyte fatty acid compositions of 105 PC patients and 120 controls were determined by gas chromatography. Cases and controls were frequency matched by age and sex. Multivariable conditional logistic regression model and restricted cubic spline were applied to estimate the odds ratio with 95% confidence interval (OR, 95% CI) of erythrocyte fatty acids and PC risk. Our main findings indicated a significant negative association between levels of erythrocyte total monounsaturated fatty acids (MUFA) and n‐3 polyunsaturated fatty acids (n‐3 PUFA) and the risk of PC (ORT3‐T1 = 0.30 [0.14, 0.63] and ORT3‐T1 = 0.15 [0.06, 0.33], respectively). In contrast, erythrocyte n‐6 polyunsaturated fatty acids, specifically linoleic acid (LA) and arachidonic acid (AA) levels, were positively associated with PC incidence (RT1‐T3 = 4.24 [1.97, 9.46] and ORT1‐T3 = 4.53 [2.09, 10.20]). Total saturated fatty acid (SFA), especially high levels of palmitic acid (16:0), was positively associated with the risk of PC (ORT3‐T1 = 3.25 [1.53, 7.08]). Our findings suggest that levels of different types of fatty acids in erythrocytes may significantly alter PC susceptibility. Protective factors against PC include unsaturated fatty acids such as n‐3 PUFA and MUFA.

100 Deals associated with Gamolenic acid

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