Delving into the Latest Updates on Terguride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Dironyl, Dironyl maleate, Mysalfon

+ [9]

Target

D2 receptor x prolactin

Action

agonists, antagonists

Mechanism

D2 receptor agonists(Dopamine D2 receptor agonists), prolactin antagonists(prolactin antagonists)

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic Disease

Active Indication

Hyperprolactinemia

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

(01 Jan 1994),

Hyperprolactinemia

RegulationOrphan Drug (European Union)

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Structure/Sequence

Molecular FormulaC20H28N4O

InChIKeyJOAHPSVPXZTVEP-YXJHDRRASA-N

CAS Registry37686-84-3

View All Structures (2)

This study aimed to assess the changes in metabolites from beef exudates (EXU), to reveal the potential of its application in determining beef quality.EXU were collected from 2, 4 and 6 days of chilled meat as a study model.Anal. of the EXU using the UPLC-Q-Exactive-MS platform identified 877 metabolites and 433 differential metabolites (DMs).The DMs mainly included organic acids (45), organoheterocyclic (45), lignans (38), phenylpropanoids and polyketides (22), benzenoids (19), organic oxygen (17), and nucleosides (16).Of these, 75 DMs with a KEGG ID were significantly associated with water retention, color and shear force in beef (P < 0.05).These DMs affected beef quality by participating in metabolic pathways, such as energy, carbohydrate and amino acid metabolism, ferroptosis, apoptosis and oxidative status.Based on the results of the current study, it may be feasible to estimate the quality of meat by analyzing its EXU.

01 Jul 2022·Journal of Neurological Surgery Part A: Central European NeurosurgeryQ4 · MEDICINE

Aggressive Pituitary Adenoma Not Fulfilling the New High-Risk Criteria with Progression after 18-Year Stable Clinical Course: Case Report

Q4 · MEDICINE

Article

Author: Ogawa, Yoshikazu ; Watanabe, Mika ; Tominaga, Teiji ; Kawaguchi, Tomohiro

Abstract Background The World Health Organization (WHO) classification of tumors of the endocrine organs was revised in 2017. The term atypical adenoma is no longer recommended, and tumors with rapid growth, radiologic invasion, and high Ki-67 labeling index are defined as high-risk adenomas. In this article, we present the case of an aggressive pituitary adenoma not fulfilling the new high-risk criteria with extraordinary rapid progression after very long stable disease, and discuss the remaining problem of the new criteria in terms of a complicated balance between pathologic findings and clinical features. Case Description A 67-year-old man was admitted with sellar tumor. Serum prolactin concentration was high at 4,552.2 ng/mL. Transsphenoidal surgery achieved subtotal removal. Histologic diagnosis was lactotroph cell adenoma, and Ki-67 labeling index was 2.6%. Postoperatively, magnetic resonance imaging revealed no evidence of tumor regrowth, but terguride or cabergoline administration was continued for slight hyperprolactinemia. Second surgery was performed 18 years after initial surgery because the tumor showed extraordinary rapid regrowth and hyperprolactinemia of 969 ng/mL. Histologic diagnosis was lactotroph cell adenoma with Ki-67 labeling index of 28.9% and positive immunoreactivity for p53. This case could be diagnosed as a high-risk adenoma from the beginning of treatment based on the WHO 2017 criteria, but the clinical course was unusually long and the indication of aggressive adjuvant therapy after initial surgery remained unsolved. Conclusion Pathologic confirmation for the present definition would be expected to assess the cutoff between typical adenomas and aggressive tumors.

01 Dec 2021·European Respiratory JournalQ1 · MEDICINE

“Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.” R. Dumitrascu, C. Kulcke, M. Königshoff,et al.Eur Respir J2011; 37: 1104–1118.

Q1 · MEDICINE

Article

100 Deals associated with Terguride

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