Delving into the Latest Updates on Dimefline Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Dimefline hydrochloride (JAN/USAN)

+ [4]

Target-

Mechanism-

Therapeutic Areas

Respiratory Diseases

Active Indication

Respiratory Insufficiency

Inactive Indication-

Originator Organization

Shanghai Pharmaceuticals Holding Co., Ltd.

Active Organization

Shanghai Ziyuan Pharmaceutical Co. Ltd.

Shanghai Pharmaceuticals Holding Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC20H21NO3

InChIKeyZXFQRFXLFWWKLX-UHFFFAOYSA-N

CAS Registry1165-48-6

View All Structures (2)

A sensitive method for the quantitative determination of the respiratory stimulant dimefline in 5 ml urine using capillary gas chromatography with nitrogen specific detection is presented. After the oral administration of a therapeutical amount of 16 mg dimefline to five subjects only 0.26 +/- 0.16% of the dose is excreted as the conjugated drug in 24 h. The maximum excretion rate occurred 3 h after dosing, the peak concentration being 154 +/- 60 ng ml-1. The influence of diuretics taken 2 h after the administration of dimefline was studied in three subjects. From these results it appeared that the use of acetazolamide and hydrochlorthiazide in order to circumvent a positive dimefline doping case is questionable. Due to the potent diuretic effect of furosemide, the intake of this diuretic could result in a suppression of the dimefline concentration below the detection limit of 10 ng ml-1.

01 Jan 1989·Archiv der PharmazieQ4 · MEDICINE

Synthesis and Quantitative Structure‐Activity Relationships of Analeptic Agents Related to Dimefline

Q4 · MEDICINE

Article

Author: Piero Valenti ; Maurizio Recanatini ; Paolo Da Re ; Pietro Giusti

AbstractSome new dimefline‐type derivatives have been synthesized and their pharmacological activity, as well as their distribution coefficients have been determined. The distribution coefficients of a number of previously published analogue compounds have also been measured and the QSAR analysis of the whole set has been carried out. The results of such analysis allow to point out which factors are influencing the biological activity of this group of compounds.

01 Oct 1985·Sheng li ke xue jin zhan [Progress in physiology]

[Mechanism of dimefline].

Review

Author: Huang, Q ; Zhang, J R

100 Deals associated with Dimefline Hydrochloride

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