Last update 01 Aug 2026

TROP2-CAR-NK(M.D. Anderson Cancer Center)

Overview

Basic Info

Drug Type
CAR-NK
Synonyms
IL15-Transduced, TGFBR2 KO, TROP2 CAR- Engineered Cord Blood-Derived NK Cells(M.D. Anderson Cancer Center), TROP2-CAR-NK Cells(Bellicum Pharmaceuticals)
Target
Trop-2
Action
modulators
Mechanism
Trop-2 modulators(Tumor-associated calcium signal transducer 2 modulators), Immunologic cytotoxicity, Natural killer cell replacements
Therapeutic Areas
NeoplasmsDigestive System DisordersRespiratory Diseases+ [1]
Active Indication
Metastatic Gastric CarcinomaColorectal CancerSecondary malignant neoplasm of peritoneum+ [4]
Inactive Indication
Carcinoma of ampulla of Vaterhigh grade serous adenocarcinoma of ovaryMesonephroma+ [2]
Originator Organization
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
Active Organization
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer CenterBellicum Pharmaceuticals, Inc.Bellicum Pharmaceuticals, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

7
Clinical Trials associated with TROP2-CAR-NK(M.D. Anderson Cancer Center)
NCT07631013
/ Not yet recruitingPhase 1
Phase 1 Dose Escalation And Expansion Study Of Intralesional TROP2-CAR/ IL15 TGFBR2 KO Engineered Cord Blood-Derived NK Cells In Patients With Diffused Or Multifocal Oral Premalignant Lesions
NCT07509008
/ Not yet recruitingPhase 1/2IIT
Phase 1/2 Window Of Opportunity Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cells Delivered Intraperitoneally For The Management Of Gastric Cancer Metastatic To The Peritoneum
NCT07377526
/ SuspendedPhase 1/2IIT
Phase 1/2 Study Of IL15-Transduced, TGFBR2 KO, TROP2 CAR- Engineered Cord Blood-Derived NK Cells Administered Intraperitoneally And Intravenously In Combination With Oral Belzutifan For The Management Of Pancreatic Cancer
100 Clinical Results associated with TROP2-CAR-NK(M.D. Anderson Cancer Center)
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100 Translational Medicine associated with TROP2-CAR-NK(M.D. Anderson Cancer Center)
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100 Patents (Medical) associated with TROP2-CAR-NK(M.D. Anderson Cancer Center)
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100 Deals associated with TROP2-CAR-NK(M.D. Anderson Cancer Center)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Gastric CarcinomaPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
01 Sep 2026
Colorectal CancerPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
20 Apr 2026
Secondary malignant neoplasm of peritoneumPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
20 Apr 2026
Carcinoma of ampulla of VaterPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
11 Oct 2023
high grade serous adenocarcinoma of ovaryPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
11 Oct 2023
MesonephromaPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
11 Oct 2023
Pancreatic Ductal AdenocarcinomaPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
11 Oct 2023
Platinum-Resistant Ovarian CarcinomaPhase 2
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
11 Oct 2023
HER2-negative breast cancerPhase 1
United States
Bellicum Pharmaceuticals, Inc.Bellicum Pharmaceuticals, Inc.
24 Oct 2023
Locally Advanced Malignant Solid NeoplasmPhase 1
United States
Bellicum Pharmaceuticals, Inc.Bellicum Pharmaceuticals, Inc.
24 Oct 2023
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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