Delving into the Latest Updates on AI-300 with Synapse

Overview

Basic Info

Drug Type

Allergen extract

Synonyms-

Target-

Mechanism

Immunomodulators

Therapeutic Areas

Eye Diseases

Active Indication-

Inactive Indication

Uveitis

Originator Organization

Autoimmune Technologies LLC

Active Organization-

Inactive Organization

Autoimmune Technologies LLC

Drug Highest PhaseDiscontinuedPhase 2

First Approval Date-

Regulation-

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PURPOSEThe AI-300 automated infusion device (Sumitomo Heavy Industries, Ltd., Tokyo, Japan) is subject to administration error as a function of smaller volumes of ¹⁸F-FDG dispensed via a three-way cock supplied with a disposable kit. The present study aimed to validate the administration accuracy of the AI-300 using an improved disposable kit for quantitative positron emission tomography (PET) assessment.METHODSWe determined administration accuracy between the improved and previous disposable kits by measuring variations in dispensed volumes and radioactive concentrations of ¹⁸F-FDG according to the criteria of the Japanese Society of Nuclear Medicine. A reference value was generated by measuring radioactivity using a standard dose calibrator.RESULTSThe values obtained using the previous kit deviated from the reference values by a maximum of -10.6%, and the deviation depended on dispensed volumes of ¹⁸F-FDG<0.25 mL. In contrast, the values were relatively stable when using the improved kit with dispensed ¹⁸F-FDG volumes < 0.25 mL. Variations in radioactive concentrations were relatively stable using the improved kit, whereas that of the previous kit was slightly unstable at high radioactive concentrations.CONCLUSIONThe administration accuracy of the AI-300 using the previous kit varied considerably according to smaller dispensed volumes, but the improved kit might alleviate this problem. The present results indicated that the improved disposal kit should be immediately implemented to eliminate uncertainty surrounding quantitative PET findings.

100 Deals associated with AI-300

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