Investigation of effectiveness of sake yeast supplementation (Saccharomyces cerevisiae) and S-sdenosyl methionine (SAM) in pharmacoresistant epileptic patients

Start Date03 Apr 2022

Sponsor / Collaborator

Semnan University

NCT03887169 / CompletedPhase 1/2IIT

Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.

The purpose of this study is to determine the safety and tolerance of an oral administration of methionine in the treatment of pulmonary alveolar proteinosis due to the double mutation Ala393Thr / Ser567Leu in the MARS gene. This disease is very severe and especially leads to chronic respiratory insufficiency. There is no curative treatment for this disease. The MARS gene encodes the methionine tRNA synthetase (MetRS). Mutations in this gene leads to a defect in MetRS function. In cultured mutated yeast, addition of methionine in culture medium restores MetRS function. Therefore, the investigators hypothesized that treatment of patients with methionine could have beneficial effects on the disease.

Start Date16 Sep 2019

Sponsor / Collaborator

Assistance Publique des Hôpitaux de Paris SA

100 Clinical Results associated with Methionine

100 Translational Medicine associated with Methionine

100 Patents (Medical) associated with Methionine

17,884

Literatures (Medical) associated with Methionine

01 Feb 2025·NEUROBIOLOGY OF AGING

Effects of age and dietary methionine restriction on cognitive and behavioural phenotypes in the rTg4510 mouse model of frontotemporal dementia

Article

Author: Sil, Annesha ; Riedel, Gernot ; Matos, Marina Souza ; Delibegovic, Mirela ; Souza Matos, Marina ; Platt, Bettina

Metabolic disorders such as diabetes and obesity are linked to neurodegenerative diseases, with evidence of lower brain glucose metabolism and insulin resistance in dementia patients. Dietary methionine restriction (MR) is a nutritional intervention that enhances insulin sensitivity and delays ageing-associated metabolic alterations, however, its impact on neurodegenerative diseases is not fully understood. Here, we examined the behavioural and metabolic phenotypes of a murine tauopathy model (rTg4510), which overexpresses human P301L mutated tau, at 6 and 12 months of age, assessing the impact of an 8-week dietary MR in the older group. While rTg4510 mice displayed progressive behavioural and motor impairments at both ages, MR led to significant benefits in the 12-month-old cohort, improving motor coordination, short-term memory, and social recognition. These effects were accompanied by increased glycolysis markers and FGF21R1 levels in the hippocampus, alongside unaltered glucose metabolism/adiposity. Overall, our results reveal the impact of MR on an FTD-mouse model, suggesting this as a potential therapeutic intervention to delay and/or improve the progression of tau-related disease.

01 Feb 2025·FOOD CHEMISTRY

Insight into the oxidation mechanism of coconut globulin by atmospheric cold plasma focusing on side chain amino acids

Article

Author: Li, Tong ; Zhang, Weimin ; Luo, Yangchao ; Li, Tian ; Chen, Yang

Atmospheric cold plasma (ACP), a novel non-thermal processing technology, generates active substances that stimulate protein oxidation in protein-based foods. Nevertheless, the precise mechanism through which ACP initiates amino acid oxidation on protein side chains remains ambiguous. This study primarily aimed to elucidate the mechanism of ACP-induced oxidation of coconut globulin, focusing on the process of amino acid oxidation. Analysis of protein oxidation products indicated a positive correlation between the extent of protein oxidation and the voltage and duration of ACP treatment. By analyzing the composition of amino acids and active ingredients, the study identified that the most significant changes amino acids were methionine, cysteine, and arginine, and •OH was the primary free radicals. The findings from oxidation kinetics and dynamic simulation indicated that •OH predominantly oxidized methionine, followed by L-cysteine and L-arginine. These results offer theoretical framework for understanding protein oxidation by ACP and suggest potential applications in protein-based food.

01 Jan 2025·METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatocyte-specific SLC27A4 deletion ameliorates nonalcoholic fatty liver disease in mice via suppression of phosphatidylcholine-mediated PXR activation

Article

Author: Xie, Wenmin ; Liu, Changhui ; Gonzalez, Frank J ; Zhao, Jian ; Shen, Chuangpeng ; Pan, Zhisen ; Zhao, Ling ; Gonzalez, Frank J. ; Miao, Deyu ; Gao, Yong ; Wang, Wei ; Liu, Min ; Zhong, Yanhua ; Zhong, Chong

BACKGROUND:

The protein Solute carrier family 27 member 4 (SLC27A4) is crucial for fatty acid synthesis and β-oxidation, but its role in hepatic steatosis and nonalcoholic fatty liver disease (NAFLD) progression is not fully understood.

METHODS:

Mice with AAV-mediated overexpression of Slc27a4 in liver and hepatocytes-specific deletion of Slc27a4 were fed a standard chow diet, a high-fat diet (HFD), or a methionine and choline-deficient diet (MCD). Serum and liver tissues were collected and analyzed by biochemical assay, histology, lipidomic analysis, RNA-seq analysis, qPCR, western blot and immunofluorescence.

RESULTS:

This study found elevated expression of SLC27A4 in individuals with NAFLD and OAPA-treated MPHs cells, leading to increased lipid accumulation and diet-induced liver steatosis, inflammation, and fibrosis. Conversely, hepatocyte-specific deletion of Slc27a4 improved the development of both NAFLD and NASH. SLC27A4 overexpression resulted in increased hepatic pregnane X receptor (PXR) expression and accumulation of phosphatidylcholine (PC), which activates PXR signaling and inducing SLC27A4 expression. PXR overexpression hinders the protective impact of Slc27a4 deletion on lipid accumulation and inflammation, whereas its deficiency in mice reduces the effect of Slc27a4 overexpression on NAFLD development.

CONCLUSION:

These results indicate that SLC27A4 plays a critical role of lipid accumulation and inflammation, and is implicated in the development of NAFLD progression, rendering it potentially actionable target for NAFLD treatment.

News (Medical) associated with Methionine

19 Jul 2023

·www.sciencedaily.com

More than just lifestyle and genes: New factor influencing excess body weight discovered

What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight. A new study shows that a kind of formatting of the DNA code in one gene that is associated with satiety is implicated in a slightly elevated risk of excess body weight -- at least in women. This 'epigenetic marking' is established early on during the embryonic stage. What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight. A new study by Charité -- Universitätsmedizin Berlin in Science Translational Medicine* shows that a kind of formatting of the DNA code in one gene that is associated with satiety is implicated in a slightly elevated risk of excess body weight -- at least in women. This "epigenetic marking" is established early on during the embryonic stage. People who are overweight, especially those who are severely overweight, are at increased risk of a number of serious diseases such as cardiovascular disease, diabetes, and cancer. It is a growing health issue. All over the world, the number of overweight people is increasing. In the European Region, two out of three adults (59 percent) are overweight or obese, according to the World Health Organization. But what determines whether people will become overweight? Genetic predisposition plays a major role, alongside lifestyle. The similarity of the body mass index (BMI) in identical twins ranges from 40 to 70 percent. Even identical twins raised in different families still show the same significant similarity. Scientists have identified several genetic variants that influence a person's body weight -- and with it, the risk of developing obesity. But even taken all together, they cannot explain the heritability that has been observed. Researchers began to suspect there must be additional non-genetic factors that affect a person's propensity to gain excess weight. Satiety gene is not altered, but formatted Researchers led by Prof. Peter Kühnen, Director of the Department of Pediatric Endocrinology at Charité, have now identified one such factor in their recent study. According to their findings, women's risk of being overweight increases by about 44 percent if there are an especially large number of methyl groups adhering to the POMC (pro-opiomelanocortin) gene, which is responsible for the feeling of satiety. Methyl groups are tiny chemical units the body uses to mark the letters in the DNA code to activate or deactivate genes without modifying the sequence of letters in the DNA. In other words, the effect is much like highlighting a section of a text without rewriting the text itself. This type of "DNA formatting" is known as epigenetic marking. For their study, the team of researchers analyzed the "formatting" of the POMC gene in more than 1,100 people. They found more methyl groups attached to the satiety gene in obese women with a BMI of over 35 than in women with normal body weight. "A 44 percent increase in the risk of obesity is about the same as the effect that has been observed for individual gene variants as well," says Kühnen. "By comparison, socioeconomic factors have a much stronger effect. They can increase the risk by a factor of two to three. As for why the methylation effect only shows up in women, we don't know yet." The POMC gene is "formatted" very early on during embryonic development, as the researchers showed by comparing methylation patterns in more than 15 sets each of identical and fraternal twins. While the "formatting" of the satiety gene was the same in most of the identical twins, there was hardly any correlation in the fraternal twins. "This indicates that the epigenetic marking of the POMC gene is established shortly after the egg and sperm cells merge, before the fertilized egg divides into two twin embryos," explains Lara Lechner, the study's first author, who works at the Department of Pediatric Endocrinology. This means the very early stage of pregnancy is crucial. What influences formatting? But what influences how much methylation the satiety gene undergoes -- and thus, the risk that a person will become overweight? Past studies indicated that the presence or absence of certain nutrients that supply methyl groups could have an effect on epigenetic processes. These nutrients include betaine, methionine, and folic acid, all of which are typically absorbed through a person's diet. A newly developed method involving individual human stem cells allowed the Charité researchers to simulate in the lab how the methylation pattern is determined during embryonic development and how nutrients affect it. "On the one hand, our studies and others as well show that folic acid, betaine, and other nutrients have a limited effect on the extent of methylation," Kühnen notes. "We've observed that the 'DNA formatting system' is very stable on the whole, with cells compensating for minor fluctuations in the nutrient supply. On the other hand, there are indications that the variability of this 'formatting' develops at random. That means that it is not possible -- not yet, at any rate -- to externally influence whether a person has more or less methylation in the POMC region." Medications may help At least in theory, women who are at elevated risk of developing obesity due to methylation of the POMC gene could receive medications to help them lose weight, as initial studies of four severely obese women and one man with this exact type of "formatting" of the satiety gene suggest. The subjects were given a specific drug that curbs the feeling of hunger and has already been approved to treat obese patients with a mutation of the POMC gene. Within three months after starting treatment, all five patients experienced less hunger. They lost an average of seven kilograms, or about five percent of their body weight. Some of them continued the treatment and continued to lose weight. "These findings show, for a start, that a POMC gene that has undergone epigenetic changes can in fact potentially be addressed through medication," Kühnen says. "Further large controlled studies will be needed to show whether treatment with this drug would also be effective over a longer period, and if so, how effective and how safe this type of treatment is. Overall, though, a medication like this would still need to be just one piece of a holistic treatment strategy."

Drug ApprovalClinical ResultOligonucleotide

12 Mar 2021

·www.globenewswire.com

Divine Locks Reviews (Complex) - Does Divine Locks Complex Really Helps Curb Hair Loss!! Review By DietCare Reviews

Chennai, March 12, 2021 (GLOBE NEWSWIRE) -- Divine Locks Complex Reviews Struggling with hair loss has both physical and psychological effects. With unhealthy hair, growth is not only stunted. Unhealthy hair leads to thin, dull, wispy stranded, and dry hair with poor scalp health. The problem with poor hair health and stunted hair growth is that it particularly affects older women. Especially at an older age, it may be difficult to find an effective treatment for hair loss. However, there may just be a solution to unhealthy hair and hair loss problem. According to the official site, the Divine Locks Complex dietary supplement is formulated to treat hair loss and poor hair growth in women. The site goes on to claim that the supplement is formulated using 29 key natural ingredients to improve hair health for all types of users – both the young and old. Click to order Divine Locks Complex from the official website & get lowest price online What Is Divine Locks Complex Supplement? Divine Locks is a dietary supplement formulated to improve hair health and stop hair loss. As mentioned above, the supplement is put together into 29 natural ingredients complied into tablets to treat the hair loss problem by supplying the body with the right nutrients. What makes the supplement stand out is that it addresses the root cause of hair loss and poor growth rather than temporarily treating symptoms. Using the supplement yields 5 key results. These include; Thicker hair Shiny hair Faster hair growth Stronger hair Bouncier hair How Does Divine Locks Complex Works For Hair Growth? According to a study conducted by Harvard medical school, there is a single hair follicle responsible for hair growth. The hair follicle has different cells responsible for different functions – like a hair shaft and cuticle. However, the dermal papillae are the cells responsible for nutrient delivery to the hair. These cells are located at the base of the hair follicle. This, in turn, means that the dermal papillae cells are responsible for hair loss, thinning, and poor hair growth. The study by Harvard medical school claims that as a person gets older, their Dermal Papilla folds over and gets pinched – thus, reducing the flow of nutrients the hair needs to grow and stay healthy. The Dermal Papilla cells work like straws – thus, as they are pinched, the flow route is distorted. As a person ages, the number of Dermal Papilla halves. With the reduced nutrient flow to the hair, the hair strands eventually begin to brittle, wispier, and ultimately, die and fall off. Physically, this leads to bald spots, thinner strands, and unhealthy hair. Thus, this explains why even the application of creams and oils may not help to regrow or improve hair health. This is where the Divine Locks jumps in. The Divine Locks formula is taken to restore the flow of nutrients to each hair stand on the head. The supplement doesn’t only reverse hair loss and kickstart hair growth. It delivers adequate nutrients to the hair for improved health and faster growth too. EXPOSED, See More: Even top doctors are stunned – Critical Report about this supplement Released! Divine Locks Ingredients Explained The Divine Locks dietary supplement is formulated with up to 29 different active ingredients to ensure its effectiveness. These include; Fo-Ti Extracted from a natural root that’s endemic to Asia, Fo-Ti is responsible for rejuvenating strong and beautiful hair. Furthermore, Fo-Ti is responsible for initiating the growth stage of the hair cycle. In fact, after just a few weeks of using Fo-Ti, hair follicles increase to double the size. With increased hair follicles, the hair is filled up with hair – filling in the bald patches and stopping hair fall out. Seaweed Extracts Seaweed extract has been proven to play a significant role in creating new Derma Papillae cells faster. Furthermore, seaweed extract is responsible for unpinching the existing Dermal Papillae cells which improve the delivery of nutrients to the hair follicles. The Divine Locks supplement is formulated using three 3 different kinds of seaweed. These include bladderwrack, nori yaki, and wakame. Gotu Kola Gotu Kola increased the size of Dermal Papillae cells and makes them wide. With wide Dermal Papillae cells means that you have larger nutrient delivery vessels. This means that the hair receives more nutrients and oxygen. With increased nutrient delivery, the hair grows faster and longer with increased density. Grape Seed Extract Grape seed extract promotes increased hair growth. It provides a thick and beautiful hairline too. Grape seed extract contains a substance called Proanthocyanins. This substance works as a color pigment – giving flowers colors like red, blue, or purple. Proanthocyanins promote hair growth too. Silica Silica is responsible for hair growth and hair thickening. Furthermore, silica reduces hair breakage. Methylsulfonylmethane (MSM) The organic compound, MSM is added to the supplement for its three key functions. It aids in improving hair appearance, hair shine, and hair volume. Biotin Nearly half of women suffering from hair loss and unhealthy hair have a biotin deficiency. Thus, it is added to the Divine Locks supplement to help with this deficiency. With adequate biotin, hair grows faster and sheds less. Selenium Rich in antioxidants, selenium promotes hair growth by eliminating free radicals from the body. Additionally, as an antioxidant, it reverses the effects of oxidative stress on the hair cells to improve their functions. Furthermore, Selenium is responsible for regenerating antioxidants within the body naturally. L-Methionine A sulfur containing amino acid, L-methionine plays a role in cell physiology as it works as an antioxidant. Furthermore, it improves cellular health by breaking down fats and heavy metals. Additionally, l-methionine prevents premature hair loss. Alpha Lipoic Acid Alpha lipoic acid supports the healthy inflammatory and antioxidant responses to improve hair health. Astaxanthin Similar to Fo-Ti, Astaxanthin helps to increase the amount of hair follicles – resulting in more hair growth and thicker hair. Hyaluronic Acid Hyaluronic acid unpinches Dermal Papillae cells to increase nutrients and oxygen delivered to the hair follicles. Furthermore, increased delivery of nutrients stimulates cell (Dermal Papillae cells) proliferation. In addition to the ingredients listed above, the Divine Locks dietary supplement contains other key ingredients. These include vitamin C, vitamin E, vitamin B6, pantothenic acid, zinc, copper, manganese, bovine (collagen), keratin, amla fruit, goji berry, and olive water. Learn more about the science behind the Divine Locks Complex ingredients Divine Locks Complex Dosage As a daily recommended supplement, a person should take at least 2 tablets of the Divine Locks formula per day. It is advised that the tablets are taken in the morning with a glass of water with breakfast. To ensure maximum results, it is recommended to take the Divine Locks Complex supplements daily without skipping any day. According to the official site, a person begins to see results in just 30 days of using the Divine Locks hair supplement. In this time, a person will begin to see results such as shedding reduction by up to 80% or higher, thicker hair at the roots, and regrowth in areas that have been bald for quite a while. According to the site, the Divine Locks tablets work by unpinching and proliferating Dermal Papillae cells in a week. Thus, as the Dermal Papillae cells grow nutrient and oxygen delivery to the hair follicles increase. The site goes on to claim that whilst the supplements work are intended to work in 30 days, actual changes can be observed at varying times. Whilst a person may notice changes in 30 days, another person may do the same in less or more days. Therefore, it is advised to take the supplements for at least 6 months to experience optimum results. Is Divine Locks Complex legit? Find out here Benefits of Divine Locks Complex According to the online Divine Locks Complex before and after customer reviews are positive; the Divine Locks supplements improve more than just hair growth. Unlike other hair supplements, the Divine Locks formula is packed with nutrients to improve overall hair health for good. Amongst other benefits include; Full and faster hair growth Adequate supply of nutrients including essential vitamins and nutrients to the hair Thicker and voluminous bouncy hair Divine Locks Complex reduces hair breakage Eliminated split ends Strong hair to allow curling Divine Locks Complex helps beautiful looking and shiny healthy hair Healthier scalp Where to Buy Divine Locks for the Best Price? The Divine Locks Complex supplement can be purchased exclusively from the official site. This means that the supplements are not available in other marketplaces such as Amazon or Walmart. According to the site, this is done for a reason – to protect the customer from scammers and duplicators. At the moment, the Divine Locks supplements are available in a choice of three different pricing packages at a discounted price. The lowest package comes with a single 60-capsule bottle that lasts for 30 days. Instead of $290, this bottle is now available for only $39 – a discount of $251. Furthermore, the single bottle is shipped out at a small shipping fee. Alternatively, the 3-month package is another option. It comes with three 60-capsule bottles – each costing $37. In total, the customer will save up to $759. For the best value, the Divine Locks dietary supplements are available in a 6-month package which comes with up to 6 bottles Costs $34 – offering a total of $1,536 and receiving free shipping. In addition to the discounted prices, each Divine Locks supplement bottle comes with a 100% risk-free 180-day money back guarantee. This means that a person can use the supplements for up to 6 months within purchase – if they are not impressed, they can request a full refund. Additionally, the site claims that every Divine Locks comes with a 2-year shelf life. This means that even with the 6-month package, the supplements will not get to half of the shelf life before the tablets are depleted. Check Current 2021 Divine Locks Complex Supplement Pricing & Discounts: Visit Official Website Here!! Divine Locks Reviews - The Final Verdict Overall Divine Locks Complex reviews conclusion, the Divine Locks Complex supplement is quite unique from other supplements. Divine Locks reviews show that works by tackling the root cause of hair loss and stunted growth – thus, improving the overall health of the hair. Furthermore, the supplement addresses other areas of the hair to make it shiny, strong, and voluminous. After using the supplement, a person can go back to enjoying the styles they rocked in the 20s with full confidence. Additionally, to ensure lifelong health, the Divine Locks tablets ensure an adequate supply of nutrients and oxygen to the hair permanently. However, it is important to remember that Divine Locks Complex is merely a dietary supplement. Therefore, it should not be used as a replacement for prescribed medication or treatment plans. In fact, it is advised to consult a physician before taking the supplement – to get an OK. Furthermore, the supplement is advised against use for pregnant women, women who breastfeed, and people under the age of 18 years old. Click to order Divine Locks Complex from the official website & get lowest price online Product Contact: support@divinelockscomplex.com C/O Inner Beauty & You 37 Inverness Drive E Ste 100 Englewood, CO 80112 By Phone: United States, Australia, UK & Canada: (866) 393-3483 About: DietCare Reviews DietCare Reviews shares e-commerce and sales news, product reviews and latest news on various products. This review for informational purposes only. The information does not constitute advice or an offer to buy. Any purchase done from this story is done on your own risk. Consult an expert advisor / health professional before any such purchase. Any purchase done from this link is subject to final terms and conditions of the website that is selling the product. The content on this release does not take any responsibility directly or indirectly. Dietcarereviews ( contact@dietcarereviews.com ) Medical Disclosure: The FDA will never approve a dietary supplement. According to the Food and Drug Administration, dietary supplements are a category of their own, and they are not subject to FDA regulation or approval. If a company is claiming that the FDA approves their diet supplement, run. This is a clear misrepresentation. -- This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. --- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This news has been published for the above source. 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IN NO EVENT SHALL KISS PR BE LIABLE OR RESPONSIBLE TO YOU OR ANY OTHER PERSON FOR ANY DIRECT, INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, OR EXEMPLARY DAMAGES OF ANY KIND, INCLUDING WITHOUT LIMITATION, LOST PROFITS OR LOST OPPORTUNITIES, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGES IN ADVANCE AND REGARDLESS OF THE CAUSE OF ACTION UPON WHICH ANY SUCH CLAIM IS BASED, INCLUDING, WITHOUT LIMITATION, ANY CLAIM ARISING OUT OF OR IN CONNECTION WITH ANY OF THE CONTENT, INCLUDING, WITHOUT LIMITATION, AUDIO, PHOTOGRAPHS, AND VIDEOS, OF OR THE ACCURACY OF ANY STATEMENT MADE IN OR OMITTED FROM ANY ADVERTISEMENT, SPONSORSHIP, ENDORSEMENT, TESTIMONIAL, OPINION, OR OTHER PRODUCT-RELATED OR SERVICE-RELATED STATEMENT OR REVIEW APPEARING IN THE WEBSITES OR IN ANY POST OR ARTICLE DISTRIBUTED VIA THE WEBSITES. © 2021 KissPR.com LLC Media Contact Website: [KISS PR Brand Story PressWire] - Email: Media@kisspr.com Attachment Divine Locks Complex Reviews 2021

23 Jan 2021

·www.globenewswire.com

Zenith Lab’s Hair Revital X – Do This Supplement Ingredients Really Effective? Hair Revital X Reviews by Nuvectramedical

McHenry, IL, Jan. 23, 2021 (GLOBE NEWSWIRE) -- A frustrating problem that both men and women face over the age of 40 is hair fall. The most important feature of your body is your hair. It makes you look more beautiful and is also a factor that gives you confidence about yourself. Already Planned to Order? Click Here to Buy Hair Revital X Supplement Won't you feel completely lost if you start losing your hair? Each morning when you wake up from the bed, how would you feel when you see your hair all over the pillow? Or right after taking a shower, your hair getting clogged on the shower sink? Nothing could be more devastating than seeing your own hair shedding in front of your eyes. It becomes more painful if you're not able to find the right solution for it. But not to worry anymore! This never-ending problem of yours has now got an incredible solution. Hair Revital X is going to be your hair growth remedy that you can completely trust on. It activates the growth factors of your hair and stops further hair fall so that you will not be losing any more of your valuable hair. Know About the Hair Revital X Hair Revital X is an extraordinary combination of a dietary supplement and a topical solution that is specially made to address the most common and unavoidable problem which is hair fall. None of the hair fall control shampoos provides a permanent solution to your hair fall problem. They only make you spend nearly $60 a month. But all you end up having is the same hair fall problem and a complete loss of the money that you invested on the shampoo. But Hair Revital X stands apart from this. The natural substances present in it, destroys all the factors that are stopping your hair growth and makes your hair grow from the root. This concentrates both on hair growth and hair fall control. You no longer need to worry about your hair fall issue or try out shampoos and hair transplant treatments. Hair transplantation is only going to take your problem forward. Hair Revital X is going to take care of every strand of your hair that you will witness a positive result and a huge difference where you will see that your hair has grown better than before. Without causing any side effects Hair Revital X is going to give you back each and every single hair that you've lost and even much more than what you've lost! How Does Hair Revital X Work? Hair Revital X is formulated with a blend of natural ingredients to accelerate and maximise the hair growth in different ways like counteracting that short genetic straw and boost reducing DHT level and get free from follicles. You can get an opportunity to increase the number of follicle cells to make you feel younger and also stop damaging your follicles to stimulate better hair growth directly. Hair Revital X ingredients will quickly reduce the DHT levels to maintain in right level for stimulating hair growth and retrieves your lost hair back during the right time. Hair Revital X can realise the benefit of using blends to protect and regrow new hair by balancing DHT and Follicles to maximise the natural Hair Growth Cycle rapidly. The given regrowth extender blend is clinically tested and shortens your follicles “Shed” stage and expands the “regrowth” stage to experience better results. Read Full List of Hair Revital X Ingredients and Side Effects Before You Buy What Will You Get from Hair Revital X? By using Hair Revital X, you can improve the hair follicle cycle to start growing new healthy hair again by spending 17 hours per day in the regrowth stage for having a faster result. Once you start following Hair Revital X formulation in your daily life, it supports for healthy and shimmering hair to keep your hair young, hydrated and healthy forever. Here it supports for healthy nail, kin, and hair tissue by keeping healthy hair cell with water and oxygen to get better results on stronger hair growth, less breaking and less greying. Hair Revital X helps to lengthen your hair follicles, balance your DHT, regrowth stage and start to keep nourishing your hair cells to get healthy hair growth as much as faster. The oral capsule provides an internal tool for solving problems in the body, and topical solutions target issues directly through the skin. What Formulates the Hair Revital X? We need to know the origin of this problem before getting to know the perfect solution. Your body has a hormone called Dihydrotestosterone (DTH). It is a natural hormone that carries messages between the organs. It is responsible for a lot of growth during puberty. As you reach adulthood, their growth becomes considerably less. But when your body produces too much DTH, you experience hair fall. Every hair generally stays for a period of 4 years after which it sheds itself completely and grows again. When there is a wild growth of DTH in your body, it sends signals to your follicles and tells them to stop regrowing. As a result, many follicles get stuck at the shedding stage without reaching the regrowing stage which is why you end up losing a huge chunk of hair regularly. And this DTH imbalance could partly be a genetic reason. Hair Revital X can be stopped by what we call as DTH inhibitors. They reduce the growth of DTH. It matches the DTH hormones and makes the DTH hormones think that they have already delivered a message to the follicles. As your follicles aren't receiving any messages to stop regrowing, they automatically start growing and they get used to the normal cycle of growing, shedding and regrowing. The Hair Revital X is that DTH inhibitor that is going to help you regrow your hair. It has got the most powerful natural hair growth plant called Saw Palmetto which is said to be one of the most powerful DTH inhibitors. This can ensure that your hair stops falling and you end up getting back nothing but thick and long hair. The Hair Revital X comes up with a dietary supplement and a topical solution and now I'm about to share with you the essential natural ingredients that make up t Hair Revital X amazing hair fall rescue solution. The oral Hair Revital X supplement has got three ingredient blends. The Anti- Genetics Blend They concentrate on reducing the genetic reasons that increase the DTH growth. It has got, Nettle Leaf Extract Pygeum Bark Extract (the bark of African cherry tree ) L- Methionine (an essential amino acid that is found in your body ) The Regrowth Extender Blend Its main goal is to shorten each follicle's shed stage and increase their regrowth stage. It consists of four main ingredients Vitamin A Palmitate Phytosterols (a component from sunflower) Vitamin B5 Zinc The Healthy Hair Blend This blend supports the growth of healthy shinning hair. It is made up of four main ingredients. L- Cysteine & Vitamin B6 (they keep the hair hydrated and healthy) Folic Acid and Biotin (they produce stronger hair and supports less breaking and less greying of your hair) Together the dietary supplement of the Hair Revital X reduces the DTH growth and improves the life and growth of each hair. Likewise, the topical solution has got four ingredient blends. Anti- Genetics It has got three main ingredients. Saw Palmetto Rosemary Extract & Carthamus Thistle Extract Regrowth Extender It has got two natural ingredients. Apigenin (a component found in parsley and chamomile) Centella (a plant also called as Asian Pennywort) Healthy Hair The two ingredients that are present in this blend are, Biotinoyl Tri-Peptide 1 Panax The additional blend that's there on the topical solution is the Deep Absorption Blend. It has got three main ingredients which are, Butylene Glycol Lecithin (comes from egg yolks, sunflower seeds and soybeans) Capsaicin (comes from red pepper) These three massages your scalp from the root and helps your follicles absorb the solution. Lowest Price Guaranteed – Get Hair Revital X Supplement for The Most Discounted Price Online Known Benefits of Using Hair Revital X Hair Revital X nourishes your hair from the root. Hair Revital X can make your hair 184% denser than before. Hair Revital X reduces the DTH growth which is the main cause for your hair fall problem. Hair Revital X can give you younger looking hair. Hair Revital X comes with no side effects. All you are going to get is healthier looking thick hair. Say goodbye to your hair fall problem. Hair Revital X decreases the shedding stage of your follicles and increases the regrowing stage. How to Get the Hair Revital X? You can get this incredible solution to hair fall at an affordable cost. 30- day supply for Hair Revital X $49; 90- day supply for Hair Revital X $117 6-month supply for Hair Revital X $198 Each of which comes with a 180-day Money- Back Guarantee where you can get a refund if you're not satisfied with the product. Who should not use Hair Revital X? If you are under 18 or pregnant, you better avoid taking dietary supplements generally! It is always a good idea to consult your doctor before taking any supplement. FDA and Supplements: The FDA will never approve a dietary supplement. According to the Food and Drug Administration, dietary supplements are a category of their own, and they are not subject to FDA regulation or approval. If a company is claiming that the FDA approves their diet supplement, run. This is a clear misrepresentation. These statements have not been evaluated by the Food and Drug Administration. Hair Revital X product is not intended to diagnose, treat, cure, or prevent any disease. Conclusion – Hair Revital X Reviews Your hair fall problem is going to be long gone. With Hair Revital X all you're going to have is younger looking healthy hair that is going to boost your inner confidence like never before. Throw away those expensive shampoos that are going to cost you your hair as well as your money. Super looking thicker hair isn't too far away from you anymore. Hair Revital X promises you your every single lost hair and you're going to see the amazingly improved hair for yourself once you start using it. Visit the Official Hair Revital X Here for Huge Discount Pricing Media Contact: Zenith Labs 4610 Prime Parkway McHenry, IL, 60050, USA Email: support@tryzenith.co Phone: +1 (800) 928-1184 This product review is for informational purposes only. The information does not constitute advice or an offer to buy. Any purchase made from this story is made at your own risk. Consult an expert advisor/health professional before any such purchase. Any purchase made from this link is subject to the final terms and conditions of the website selling the product. The content on this release does not take any responsibility directly or indirectly. Contact Nuvectramedical at vijai@nuvectramedical.com This news has been published for the above source. 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This disclosure applies to content displayed on all mobile, desktop, and other online versions of KISS PR’s websites and to those of KISS PR’s distribution partners (hereinafter referred to collectively as “the Websites”) and is provided for the purpose of disclosing the nature of the connection between KISS PR and product reviewers, advertisers, sponsors, endorsers, and other third-parties whose advertisements, sponsorships, endorsements, testimonials, opinions, or other product-related or service-related statements or reviews may appear on the Websites (hereinafter referred to as an "Product Reviewer"). This Product Reviewer Compensation Disclosure is intended to disclose to you that in consideration of payment of monetary and other compensation from a Product Reviewer, as described below, KISS PR sells various advertising, sponsorships, and marketing campaigns that are featured on one or more of the Websites. There is a financial connection related to some of the products or services mentioned, reviewed, or recommended on the Websites between KISS PR and the Product Reviewer that owns, markets, or sells such product or service. If you decide to purchase a product or service featured on one or more of the Websites, KISS PR will not receive compensation related to that purchase from a Product Reviewer but may receive a one-time fee from the Product Reviewer for posting or distributing the product review on or via the Websites. Further, KISS PR may post or otherwise promote on the Websites content, including editorial content, which may feature third-party products and services (a "Reviewed Product"). This content may contain weblinks to third-party owned or operated web sites where you can purchase Reviewed Product (“Product Link”). 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KISS PR will, subject to the disclaimer of liability set forth below, endeavor to ensure that product or service endorsements appearing in the Websites or in posts or articles distributed via the Websites reflect the honest opinions, findings, beliefs, or experiences of the Product Reviewer as they relate to such product or service. If you have any complaint, concern, or question relating to the content of any such post or article, including alleged infringement of any intellectual property rights, you should address your complaint, concern, or question directly to the Product Reviewer or the Vendor. NO REPRESENTATIONS OR WARRANTIES; NON-RELIANCE. EXCEPT FOR ANY EXPRESS REPRESENTATIONS AND WARRANTIES CONTAINED IN THIS DISCLOSURE STATEMENT, NEITHER KISS PR NOR ANY OTHER PERSON ON KISS PR’S BEHALF HAS MADE OR MAKES ANY EXPRESS OR IMPLIED REPRESENTATION OR WARRANTY, EITHER ORAL OR WRITTEN, WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE, TRADE, OR OTHERWISE, ALL OF WHICH ARE EXPRESSLY DISCLAIMED, AND YOU ACKNOWLEDGE THAT YOU HAVE NOT RELIED UPON ANY REPRESENTATION OR WARRANTY MADE BY KISS PR OR ANY OTHER PERSON ON KISS PR’S BEHALF, EXCEPT AS SPECIFICALLY PROVIDED IN THIS DISCLOSURE STATEMENT. DISCLAIMER OF LIABILITY. IN NO EVENT SHALL KISS PR BE LIABLE OR RESPONSIBLE TO YOU OR ANY OTHER PERSON FOR ANY DIRECT, INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, OR EXEMPLARY DAMAGES OF ANY KIND, INCLUDING WITHOUT LIMITATION, LOST PROFITS OR LOST OPPORTUNITIES, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGES IN ADVANCE AND REGARDLESS OF THE CAUSE OF ACTION UPON WHICH ANY SUCH CLAIM IS BASED, INCLUDING, WITHOUT LIMITATION, ANY CLAIM ARISING OUT OF OR IN CONNECTION WITH ANY OF THE CONTENT, INCLUDING, WITHOUT LIMITATION, AUDIO, PHOTOGRAPHS, AND VIDEOS, OF OR THE ACCURACY OF ANY STATEMENT MADE IN OR OMITTED FROM ANY ADVERTISEMENT, SPONSORSHIP, ENDORSEMENT, TESTIMONIAL, OPINION, OR OTHER PRODUCT-RELATED OR SERVICE-RELATED STATEMENT OR REVIEW APPEARING IN THE WEBSITES OR IN ANY POST OR ARTICLE DISTRIBUTED VIA THE WEBSITES. © 2021 KissPR.com LLC Media Contact Website: [KISS PR Brand Story PressWire] - Email: Media@kisspr.com Attachment Zenith Lab’s Hair Revital X – Do This Supplement Ingredients Really Effective? Hair Revital X Reviews by Nuvectramedical

100 Deals associated with Methionine

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KEGG	Wiki	ATC	Drug Bank
D00019	Methionine	V03AB26	DB00134

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Indication	Country/Location	Organization	Date
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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00597246 (CTgov)	Not Applicable	Brain Cancer	30	1-t-butyl carbamate-3- trifluoromethane sulfonoxy-1-cyclobutane-1+FACBC+F-18 fluoride	yaytrplctg(kzzqyzyqwi) = hupisbgeqk zqcymfdoxr (bqegkeuahj, uwwmgakvbt - iqdorohztm) View more	-	17 Dec 2020
ASTRO	Not Applicable	Brain Cancer	-	Methionine (CTV-Gd (20 mm))	gldqrykddj(uehxdqihno) = pjwwbkbzvl slvnhvgwsq (zelvoyxnez )	-	01 Sep 2019
				Methionine (CTV-T2 (20 mm))	gldqrykddj(uehxdqihno) = kijyhpabfn slvnhvgwsq (zelvoyxnez ) View more
NCT02526524 (CTgov)	Phase 2	Diabetes Mellitus, Type 2	571	Met DR (600 mg Met DR qAM)	bcvtjdztyp(fzlxhhpugd) = kiqhuszwuz bhtbuvuvhh (waobyqyqqt, rwsevxmkxz - vtikwajqxy) View more	-	27 Apr 2018
				Met DR (900 mg Met DR qAM)	bcvtjdztyp(fzlxhhpugd) = sorzmlkiur bhtbuvuvhh (waobyqyqqt, mmyrlumnxs - brlnytzsoc) View more
NCT01804842 (CTgov)	Phase 1/2	Diabetes Mellitus, Type 2	26	Met DR (500 mg Met DR BID)	iguckdbmlk(oykhpxxtxl) = zyacipbolq uovplfktbk (zievjgxkve, bfjfuqmgbu - iqyecdhism) View more	-	07 Apr 2016
				Met DR (1000 mg Met DR qAM)	iguckdbmlk(oykhpxxtxl) = ziborfyzjo uovplfktbk (zievjgxkve, dujfhyylwv - dtatrlyubn) View more
NCT02291510 (CTgov)	Phase 1	-	20	Met DR (500 mg Met DR BID)	jihxsdcebd(ungdapkzto) = gdfpimaucu cpobjcsqog (pgkxxoyhok, wxivfdpnkr - hlsvkjitly) View more	-	21 Sep 2015
				Met DR (1000 mg Met DR BID)	jihxsdcebd(ungdapkzto) = qgvyjchgus cpobjcsqog (pgkxxoyhok, lfcxfbetph - lkfezloicr) View more
SFN2006	Not Applicable	-	-	methionine 35 (Native Aβ)	ncftseoyad(fvknejqqhi) = ofmagdwrqt oswgxaylff (gjloocftvf )	-	14 Oct 2006

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