Delving into the Latest Updates on S-allyl-L-cysteine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

S-allyl L-cysteine

+ [3]

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular DiseasesCongenital DisordersEndocrinology and Metabolic Disease+ [1]

Active Indication

Inactive Indication

GastritisPeptic UlcerRecurrent ulcer+ [1]

Originator Organization

Pharma King Co., Ltd.

Active Organization

University of British Columbia

University of Aston

Inactive Organization

Pharma King Co., Ltd.

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC6H11NO2S

InChIKeyZFAHNWWNDFHPOH-YFKPBYRVSA-N

CAS Registry21593-77-1

Changes in chemical composition during food processing and handling are crucial for the alteration of food flavor and function, and accurate characterization of key chemical reaction pathways in complex food matrices is one of the core challenges in food chemistry research. Here, this study attempts to establish a strategy for sensitive characterization of chemical reactions during food processing based on on-line extraction electrospray ionization mass spectrometry (oEESI-MS). The process of making garlic into black garlic, a traditional global flavor food, was chosen as an exemplary research template. The direct MS characterization of raw garlic as well as black garlic samples with different processing times was achieved by using the self-constructed oEESI-MS device. Benefiting from the high tolerance of oEESI-MS to complex matrix interferences, all samples can be fingerprinted directly without any pre-processing or pre-separation. As a result, oEESI-MS achieved a sensitive characterization of the changes of key substances during the preparation of black garlic. Further, a new chemical reaction pathway, the degradation of γ-L-glutamyl-S-allyl-L-cysteine to S-allyl-l-cysteine, was completely demonstrated by analyzing the differential substances before and after the treatment, and verified by standard substances and chemical theory calculations. In conclusion, a complete oEESI-MS-based strategy for tracking the substance changes in food processing was established in this study, which has a widely applicable prospect for the precise setting of food processing time and parameters, and the innovation of processing technology.

01 Apr 2025·Plant Physiology and Biochemistry

The protective roles of boron against copper excess in citrus roots: Insights from physiology, transcriptome, and metabolome

Article

Author: Shen, Qian ; Huang, Wei-Lin ; Chen, Li-Song ; Huang, Wei-Tao ; Huang, Zeng-Rong ; Lu, Fei ; Chen, Xu-Feng ; Yang, Lin-Tong ; Lai, Ning-Wei

Boron (B) deficiency and copper (Cu) excess are common problems in citrus orchard soils. Citrus sinensis seedlings were exposed to 25 (B25) or 2.5 (B2.5) μM H₃BO₃ and 0.5 (Cu0.5) or 350 (Cu350) μM CuCl₃ for 24 weeks. Cu350 upregulated 2210 (1012) genes and 482 (341) metabolites and downregulated 3201 (695) genes and 175 (43) metabolites in roots at B2.5 (B25). Further analysis showed that the B-mediated mitigation of Cu toxicity in roots involved the coordination of the following aspects: (a) enhancing the ability to maintain cell wall and plasma membrane stability and function; (b) lowering the impairment of Cu350 to primary and secondary metabolisms and enhancing their adaptability to Cu350; and (c) alleviating Cu350-induced oxidative stress via the coordination of reactive oxygen species (ROS) and methylglyoxal detoxification systems. Cu350 upregulated the abundances of some saccharides, amino acids and derivatives, phospholipids, secondary metabolites, and vitamins, and the expression of several ROS detoxification-related genes in roots of B2.5-treated seedlings (RB2.5), but these adaptive responses did not prevent RB2.5 from Cu-toxicity (oxidative damage). The study identified some genes, metabolites, and metabolic processes/pathways possibly involved in root Cu tolerance. Additionally, the responses of gene expression and metabolite profiling to Cu-B treatments differed between leaves and roots. Therefore, this study provided novel information for B to reduce Cu toxicity in roots and might contribute to the development of soil amendments targeting Cu excess in citrus and other crops.

01 Apr 2025·Biomaterials

LIFU-unlocked endogenous H2S generation for enhancing atherosclerosis-specific gas-enzymatic therapy

Article

Author: Jiang, Weixi ; Li, Pan ; Du, Chier ; Cheng, Chen ; Zhou, Zhiyi ; Ren, Jianli ; Wang, Jingxue ; Xu, Min ; Ran, Haitao ; Wang, Xiaoting ; An, Hongjin ; Guo, Xun ; Hou, Shengzhe ; Wang, Zhigang ; Qiu, Xiaoling

Atherosclerotic plaques, which are characterized by endothelial oxidative stress, lipid metabolism disorders and persistent inflammation, can induce serious cardiovascular diseases. However, the pharmacotherapies currently used to treat atherosclerosis (AS), such as lipid-lowering and antithrombotic drugs, can regulate only a single pathological feature of AS, and there is still a dearth of integrated platforms for the multifaceted regulation of AS progression. Herein, we developed a synergistic combination of endogenous H₂S gas therapy with a multienzyme-like nanozyme (named ^LyP-1Lip@HS) for the treatment of AS. The high affinity of the LyP-1 peptide for macrophages and foam cells within plaques allows ^LyP-1Lip@HS to actively target atherosclerotic lesions. After cavitation was induced by low-intensity focused ultrasound (LIFU), the lipid membrane of ^LyP-1Lip@HS was disrupted, thereby "unlocking" the enzyme-like activity of hollow mesoporous Prussian blue (HMPB) and facilitating the release of the endogenous H₂S donor S-allyl-L-cysteine (SAC). Notably, H₂S endogenously generated by enzymatic catalysis plays multiple roles, upregulating the ATP-binding cassette transporter A1 in foam cells to increase lipid efflux and promote the conversion of M1 macrophages to M2 macrophages. Moreover, the high level of reactive oxygen species in the inflammatory microenvironment of the plaque was mitigated. Overall, ^LyP-1Lip@HS provides a specific and controlled treatment to prevent oxidative stress, inflammation and lipid metabolism disorders, making it a candidate for AS treatment.

100 Deals associated with S-allyl-L-cysteine

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Age Related Macular Degeneration	Preclinical	Canada	University of British Columbia	22 Jan 2024
Age Related Macular Degeneration	Preclinical	United Kingdom	University of Aston	22 Jan 2024
Diabetic Retinopathy	Preclinical	United Kingdom	University of Aston	22 Jan 2024
Diabetic Retinopathy	Preclinical	Canada	University of British Columbia	22 Jan 2024
Glaucoma	Preclinical	Canada	University of British Columbia	22 Jan 2024
Glaucoma	Preclinical	United Kingdom	University of Aston	22 Jan 2024
Peptic Ulcer	Discovery	South Korea	Pharma King Co., Ltd.	24 Nov 2014
Recurrent ulcer	Discovery	South Korea	Pharma King Co., Ltd.	24 Nov 2014
Gastritis	Discovery	United States	Pharma King Co., Ltd.	01 Dec 2012
Stomach Ulcer	Discovery	United States	Pharma King Co., Ltd.	01 Dec 2012