Effect of Dexmedetomidine on the ED50 and ED95 of Sufentanil in Patient-Controlled Intravenous Analgesia After Cesarean Section: A Randomized, Controlled, Double-Blind Trial

Article

Author: Fu, Wuchang ; Wang, Na ; Li, Jiabei ; Zeng, Sisi ; Li, Xuechao ; Wan, Jixiang ; Wang, Fangjun

PurposeTo determine the effect of dexmedetomidine on the ED₅₀ and ED₉₅ of sufentanil in patient-controlled intravenous analgesia (PCIA) after cesarean section.Patients and MethodsParturients who underwent elective cesarean section (n = 80) were randomly assigned to either the sufentanil group (S group) or the dexmedetomidine-sufentanil combination group (DS group). Patients in the S group received a combination of sufentanil, 5 mg of tropisetron, and saline, whereas patients in the DS group were administered 1.5µg/kg of dexmedetomidine in addition to sufentanil, 5 mg of tropisetron, and saline. The ED₅₀ and ED₉₅ of sufentanil were determined by Dixon sequential method. We used probit regression to calculate the ED₅₀, ED₉₅, and 95% confidence intervals for sufentanil in each group.ResultsThe ED₅₀ and ED₉₅ for sufentanil in the S group were 1.634 (95% CI: 1.476-1.810)µg/kg and 2.035 (95% CI: 1.841-3.312)µg/kg, respectively. The ED₅₀ and ED₉₅ for sufentanil in the DS group were 1.275 (95% CI: 1.187-1.353)µg/kg and 1.503 (95% CI: 1.406-1.824)µg/kg. The VAS scores with rest at t₅ and with movement at t₄- t₅ were lower in the DS group (P< 0.05). The t₂-t₅ Ramsay scores in the DS group were higher than those in the S group (P< 0.05). The doses of sufentanil and tramadol were markedly reduced in the DS group, while the onset of first lactation occurred significantly earlier in the DS group (P< 0.05). Compared with the S group, the DS group had a lower incidence of nausea, vomiting, and skin itching (P< 0.05), and lower frequency of patient-controlled analgesia (PCA) episodes (P< 0.05), and better postoperative pain satisfaction (P< 0.05).ConclusionThe 1.5µg/kg dexmedetomidine can significantly decrease the ED₅₀ and ED₉₅ of sufentanil in patient-controlled intravenous analgesia after cesarean section, provide good postoperative analgesia and sedation, and promote the earlier occurrence of first lactation.

100 Deals associated with Tropisetron Mesylate

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Indication	Country/Location	Organization	Date
Chemotherapy-induced nausea and vomiting	CN	Beijing Wellso Pharmaceutical Co., Ltd.	16 Oct 2002

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