Last update 08 May 2025

Mannitol/Proline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Prodarsan
Target
Free radicals
Action
modulators
Mechanism
Free radicals modulators(Free radicals modulators)
Therapeutic Areas
Nervous System DiseasesCongenital DisordersEndocrinology and Metabolic Disease+ [2]
Active Indication-
Inactive Indication
Cockayne Syndrome
Originator Organization
Pharming Group NVPharming Group NV
Active Organization-
Inactive Organization
Pharming Group NVPharming Group NVDNage BVDNage BV
License Organization-
Drug Highest PhaseDiscontinuedPhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC6H14O6
InChIKeyFBPFZTCFMRRESA-KVTDHHQDSA-N
CAS Registry69-65-8
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Related

1
Clinical Trials associated with Mannitol/Proline
NCT01142154
/ CompletedPhase 1/2
A Phase I/II Crossover Study To Evaluate and Compare the Pharmacokinetics of a Single IV Dose of D-Mannitol (Osmitrol®10%) to Single and Multiple, Escalating Doses of Liquid, Oral Prodarsan™ in Patients With Cockayne Syndrome
100 Clinical Results associated with Mannitol/Proline
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100 Translational Medicine associated with Mannitol/Proline
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100 Patents (Medical) associated with Mannitol/Proline
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1
News (Medical) associated with Mannitol/Proline
14 Aug 2009
Pharming Group Gets U.S. Okay for Prodarsan Trial
100 Deals associated with Mannitol/Proline
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cockayne SyndromePhase 2
United States
DNage BVDNage BV
01 Jun 2010
Cockayne SyndromePhase 2
United States
DNage BVDNage BV
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Approval

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Regulation

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