Delving into the Latest Updates on Mannitol/Proline with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Prodarsan

Target

Free radicals

Action

modulators

Mechanism

Free radicals modulators(Free radicals modulators)

Therapeutic Areas

Nervous System DiseasesCongenital DisordersEndocrinology and Metabolic Disease+ [2]

Active Indication-

Inactive Indication

Cockayne Syndrome

Originator Organization

Pharming Group NV

Active Organization-

Inactive Organization

Pharming Group NV

DNage BV

Drug Highest PhaseDiscontinuedPhase 1/2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC6H14O6

InChIKeyFBPFZTCFMRRESA-KVTDHHQDSA-N

CAS Registry69-65-8

View All Structures (2)

This study is to compare the exposure of orally administered Prodarsan to the intravenous dosed Osmitrol (10% solution) in Cockayne Syndrome (CS) patients. Also the pharmacokinetics of single and multiple orally dosed Prodarsan will be evaluated and compared to intravenous dose of Osmitrol in CS patients.

Start Date01 Jun 2010

Sponsor / Collaborator

DNage BV

100 Clinical Results associated with Mannitol/Proline

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100 Translational Medicine associated with Mannitol/Proline

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100 Patents (Medical) associated with Mannitol/Proline

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37

Literatures (Medical) associated with Mannitol/Proline

27 Apr 2022·mSphereQ2 · BIOLOGY

The Stickland Reaction Precursor trans -4-Hydroxy- l -Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

Q2 · BIOLOGY

ArticleOA

Author: Kountz, D. J. ; Rivera, A. J. ; Huang, Y. Y. ; Stewart, A. K. ; Fletcher, J. R. ; Thanissery, R. ; Shen, A. ; Parsons, R. J. ; Reed, A. D. ; Theriot, C. M. ; Balskus, E. P.

Proline is an essential environmental amino acid that C. difficile uses to support growth and cause significant disease. A posttranslationally modified form, hydroxyproline, is highly abundant in collagen, which is degraded by host proteases in response to C. difficile toxin activity.

01 Jan 1982·Acta cientifica venezolana

[5'nucleotidase activity in the venom of Bothrops atrox (L.) Jergón].

Article

Author: Yarlequé, A ; Heredia, V ; Campos, S

01 Jun 1981·Indian journal of biochemistry & biophysics

Characteristics of proline transport in the spheroplasts isolated from Candida albicans cells.

Article

Author: Singh, M ; Jayakumar, A ; Baquer, N Z ; Verma, R S ; Prasad, R

1

News (Medical) associated with Mannitol/Proline

14 Aug 2009

·www.biospace.com

Pharming Group Gets U.S. Okay for Prodarsan Trial

Reuters -- Biotechnology company Pharming Group on Friday said the U.S. Food and Drug Administration accepted its investigational new drug application for Prodarsan, permitting a clinical trial to proceed.

100 Deals associated with Mannitol/Proline

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