Delving into the Latest Updates on Geraniol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

NeoplasmsOther Diseases

Active Indication-

Inactive Indication

InflammationNeoplasms

Originator Organization

Paediatrics Hospital Affiliated To Fudan University

Active Organization-

Inactive Organization

Paediatrics Hospital Affiliated To Fudan University

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC10H18O

InChIKeyGLZPCOQZEFWAFX-JXMROGBWSA-N

CAS Registry106-24-1

Lespedeza bicolor Turcz. is a traditional medicinal plant with a wide range of ethnomedicinal values.The main components of L. bicolor essential oil (EO) were β-pinene (15.41%), β-phellandrene (12.43%), and caryophyllene (7.79%).The EO of L. bicolor showed antioxidant activity against ABTS radical and DPPH radical with an IC₅₀ value of 0.69 ± 0.03 mg/mL and 10.44 ± 2.09 mg/mL, resp.The FRAP antioxidant value was 81.96 ± 6.17 μmol/g.The EO had activities against acetylcholinesterase, α-glucosidase, and β-lactamase with IC₅₀ values of 309.30 ± 11.16 μg/mL, 360.47 ± 35.67 μg/mL, and 27.54 ± 1.21 μg/mL, resp.Mol. docking showed Me dehydroabietate docked well with all tested enzymes.Sclareol and (+)-borneol acetate showed the strongest binding affinity to α-glucosidase and β-lactamase, resp.The present study provides a direction for searching enzyme inhibitors for three tested enzymes and shows L. bicolor EO possesses the potential to treat a series of diseases.

01 Jun 2025·Toxicology Reports

Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity

Article

Author: Araújo, Isaac Moura ; de Oliveira Borges, João Arthur ; Tintino, Saulo Relison ; Pereira, Raimundo Luíz Silva ; de Azevedo, Francisco Roberto ; de Sousa Silveira, Zildene ; Paulo, Cícera Laura Roque ; Filho, José Maria Barbosa ; Macedo, Nair Silva ; Bezerra da Cunha, Francisco Assis ; Coutinho, Henrique Douglas Melo ; de Araújo, Gildênia Alves ; Morais Oliveira Tintino, Cícera Datiane de ; Amaral Ferraz Navarro, Daniela Maria do ; da Silva, Ângella Eduarda ; de Sousa Rodrigues, Ewerton Yago

This study aimed to evaluate the antibacterial activity against multi-drug-resistant strains carrying efflux pumps and assess their toxicity on Drosophila melanogaster and Aedes aegypti models. Microdilution tests in broth were performed to determine the Minimum Inhibitory Concentration (MIC). The efflux pump inhibition was evaluated by analyzing the reduction in antibiotic MIC and Ethidium Bromide (EtBr) MIC when combined with the products. Mortality assay and negative geotaxis were conducted on D. melanogaster specimens, and insecticidal activity assays were performed on A. aegypti larvae. Only geraniol reduced the antibiotic MIC when combined, reducing from 64 µg/mL to 16 µg/mL in the 1199B strain of S. aureus. When combined with EtBr, both geraniol and citral reduced EtBr MIC, with geraniol decreasing from 64 µg/mL to 16 µg/mL and citral decreasing from 64 µg/mL to 32 µg/mL. Regarding the S. aureus K2068 strain, geraniol reduced the antibiotic MIC from 16 µg/mL to 8 µg/mL, and citral reduced it from 16 µg/mL to 4 µg/mL. In combination with EtBr, all monoterpenes reduced MIC from 64 µg/mL to 32 µg/mL. Both products exhibited toxicity in D. melanogaster; however, citral showed higher toxicity with a precisely determined LC50 of 2.478 μL. As for the insecticidal action on A. aegypti, both products demonstrated toxicity with cumulative effects and dose-dependent mortality.

01 May 2025·Food Chemistry

Long-term study of Citrus changshan-huyou Y.B. Chang essential oil: Chemical transformations and their impact on antibacterial efficacy

Article

Author: Xiao, Wenbin ; Liu, Ting ; Guo, Jiajing ; Li, Gaoyang ; He, Mingwang ; Fu, Fuhua ; Li, Zixuan ; Shang, Xuebo ; Fu, Yanjiao ; Gao, Zhipeng ; Xiao, Yangbo ; Su, Donglin ; Shan, Yang ; Zhang, Tongping

The essential oil from Citrus changshan-huyou Y.B. Chang (HYEO) contains volatile compounds with strong inhibitory effects on biofilms formed on food processing equipment. This study analyzed the compositional changes of HYEO over 9 years and evaluated its antibacterial and antibiofilm properties. HYEO showed significant antibacterial activity during the first 8 years, effectively removing mature biofilms. Gas chromatography-mass spectrometry analysis revealed that monoterpenes were the primary components, with d-limonene and γ-terpenes converting into oxygenated derivatives during storage, resulting in a more than 16-fold increase in antibacterial activity. The antibacterial strength correlated with the number of oxygenated derivatives from limonene and terpinene among the top 20 components. Significant associations were observed between antibacterial activity and the oxygenated derivatives of d-limonene and γ-terpenes. These findings suggest the need for further investigation into their synergistic effects, antibacterial mechanisms, potential applications in food processing, and the safety profiles of the main antibacterial components of HYEO.

100 Deals associated with Geraniol

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Inflammation	Preclinical	China	Paediatrics Hospital Affiliated To Fudan University	04 Apr 2019
Neoplasms	Preclinical	China	Paediatrics Hospital Affiliated To Fudan University	04 Apr 2019