Delving into the Latest Updates on Geraniol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

NeoplasmsOther Diseases

Active Indication-

Inactive Indication

InflammationNeoplasms

Originator Organization

Paediatrics Hospital Affiliated To Fudan University

Active Organization-

Inactive Organization

Paediatrics Hospital Affiliated To Fudan University

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC10H18O

InChIKeyGLZPCOQZEFWAFX-JXMROGBWSA-N

CAS Registry106-24-1

Lespedeza bicolour Turcz. is a traditional medicinal plant with a wide range of ethnomedicinal values. The main components of L. bicolour essential oil (EO) were β-pinene (15.41%), β-phellandrene (12.43%), and caryophyllene (7.79%). The EO of L. bicolour showed antioxidant activity against ABTS radical and DPPH radical with an IC₅₀ value of 0.69 ± 0.03 mg/mL and 10.44 ± 2.09 mg/mL, respectively. The FRAP antioxidant value was 81.96 ± 6.17 μmol/g. The EO had activities against acetylcholinesterase, α-glucosidase, and β-lactamase with IC₅₀ values of 309.30 ± 11.16 μg/mL, 360.47 ± 35.67 μg/mL, and 27.54 ± 1.21 μg/mL, respectively. Molecular docking showed methyl dehydroabietate docked well with all tested enzymes. Sclareol and (+)-borneol acetate showed the strongest binding affinity to α-glucosidase and β-lactamase, respectively. The present study provides a direction for searching enzyme inhibitors for three tested enzymes and shows L. bicolour EO possesses the potential to treat a series of diseases.

01 Aug 2025·Biosensors and Bioelectronics

Nondestructive methodology with discerning fruit freshness biomarker compounds using olfactory receptor nanodisc-loaded graphene transistors

Article

Author: Cho, Seongyeon ; Seo, Sung Eun ; Kwon, Oh Seok ; Park, Tai Hyun ; Song, Hyun Seok ; Cha, Yeon Kyung ; Lee, Seongbin ; Lee, Jiwon ; Ryu, Yong-Sang ; Kim, Kyung Ho

Noninvasive and facile methodologies for the assessment of fruit freshness are essential for the determination of fruit ripeness. Fruits emit characteristic aroma molecules during maturation, and the selective and sensitive detection of these scents is highly challenging. Herein, a novel nondestructive methodology for discerning fruit freshness biomarker compounds based on a target-specific olfactory receptor-loaded transistor for detecting aroma molecules at ppb levels is proposed. This fruit freshness discrimination platform can detect the representative aromas caused by compounds including iso-amyl acetate, amyl-butyrate, geraniol, and β-citronellol that are emitted by each fruit species, such as bananas, grapes, and apricots, and has a lower limit of detection below femtomolar concentrations. Measurement of the selective binding affinity between the olfactory receptor and aroma molecules was conducted using biosimulation, and the experimental results were compared with the sensor response. The fabricated sensor exhibited superior performance in determining the ripeness of fruits with discerning fruit freshness biomarker compounds and presented promising potential for application in agriculture and other industry fields as an assessment platform for detecting various aromatic molecules. Our findings highlight the broad utilization of newly developed sensor platforms as standards for distinguishing freshness.

01 Aug 2025·Food Chemistry

Agronomic characteristics, objective quantitative, metabolome and transcriptome analysis reveal the influence of fertilization treatments on fresh leaf characteristics and finished tea quality

Article

Author: Wang, Jinjin ; Zhang, Fenglan ; Liu, Ping ; Hua, Jinjie ; Chen, Ming ; Yu, Ziming ; Zhu, Xizhe ; Li, Yeyun ; Huang, Youyi ; Yuan, Haibo ; Yang, Liyue ; Hu, Bicheng

Fertilization is important for tea garden management and tea flavor improvement; however, the effects of different ratios of organic and chemical fertilizer on fresh tea leaf quality and finished tea flavor remain unclear. Therefore, four fertilization treatments were used to elucidate the underlying mechanisms. Fertilization treatments increased tea yield, and organic fertilizer increased bud density. Organic fertilizer reduced bitter rutin and γ-aminobutyric acid content and phenol-to-ammonia ratio, and increased theanine, glutamic acid, quercetin-3-O-glucoside, kaempferol-3-O-rutinoside, and (-)-epicatechin-3-O-gallate content, resulting in umami taste and bright green color of green tea. Nine key differential volatiles were screened, and organic fertilizer markedly increased the levels of floral and fruity volatiles, including indole, decanal, linalool, geraniol, and cis-jasmone, resulting in lasting orchid aroma. Transcriptome analysis showed that organic fertilizer upregulated genes related to phenylalanine conversion and fatty acid metabolism, resulting in excellent tea quality. The results provide robust support for precise quality improvement in tea production.

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Inflammation	Preclinical	China	Paediatrics Hospital Affiliated To Fudan University	04 Apr 2019
Neoplasms	Preclinical	China	Paediatrics Hospital Affiliated To Fudan University	04 Apr 2019