There is a global concern about iodinated contrast media because they may be an anthropogenic source of iodine, and thereby precursors of iodinated disinfection byproducts during chlorine disinfection.These byproduct compounds may exert higher toxicity than regulated-disinfection byproducts (i.e., trihalomethanes and haloacetic acids).This represents a challenge for water utilities due to the unknown formation of these iodinated disinfection byproducts.This work is two folded: on one hand, it researches the effects of ozone as pretreatment for iopamidol oxidation through a sequential treatment of low-pressure UV light followed by free chlorine, and in the other hand, it applies an algorithm of principal component anal. to obtain the multivariable of these sequential treatments.In this context, a formation iodinated disinfection byproducts to iodide correlation models were developed under each treatment condition (i.e., UV-Cl₂, and O₃-UV-Cl₂).Addnl., five iodinated disinfection byproducts were detected: dichloroidomethane, chlorodiiodomethane, iodoform, iodoacetonitrile and chloroiodoacetamide, corresponding to trihalomethanes, haloacetonitriles and haloacetamides resp.Showed that ozonation as a pre-treatment step (O₃-UV-Cl₂) reduced up to 53% byproducts formation than UV-Cl₂.Using principal component anal., it was found that iodinated disinfection byproducts to iodide correlation models showed a better correlation for the ozonation pretreatment with a R² = 0.9122 along with a Pearson coefficient of r = 0.9551.Ozonation should be considered as a strategy to control the formation of these iodinated byproducts for water reuse from waters enriched with anthropogenic iodine.Future experiments with different source waters should be addressed to explore the formation and control of unregulated iodinated disinfection byproducts.

01 Feb 2025·Journal of Hazardous Materials

Electroactivation of peroxymonosulfate (PMS)-coupled electrocoagulation for degradation of iodinated contrast media and reduction of I-DBPs formation: Dual control and QSAR modeling

Article

Author: Wang, Zhaoyang ; Fang, Shuai ; Hu, Wenyi ; Bian, Jin ; Li, Xin

Iodinated contrast medias (ICMs) can act as an iodine source to react with dissolved organic matter (DOM) in the chlorination process to form toxic iodinated disinfection byproducts (I-DBPs). In this study, a coupled process of electrically activated PMS and electrocoagulation (EO-PMS/EC) was constructed to simultaneously remove iopamidol (IPM) and DOM, which has a dual control effect on the formation of I-DBPs. This system achieved a 90.1 % degradation rate of IPM, as well as remarkable removal of DOM. Firstly, the effects of experimental conditions and water matrix on IPM degradation were investigated; ¹O₂, HO^·, SO₄^·-, O₂^·- and Fe (IV) are the main contributors to IPM degradation. Moreover, the transformation pathways of IPM were inferred and most of the intermediates were less toxic compared to I-DBPs. The formation of I-DBPs was reduced by 82.7 % and was effectively inhibited in all three real water samples. Furthermore, the developed QSAR model illustrate that the degradation rate constants of ICMs are positively correlated with the values of their highest occupied molecular orbital energies and dipole moments. This study provided a more effective I-DBPs reduction strategy which reduced the environmental risk of I-DBPs to a certain extent.

01 Oct 2024·Journal of Chromatography B

A validated LC-MS/MS method for the simultaneous quantification of iothalamate and hippuran in serum and urine for non-radioactive kidney function assessment

Article

Author: van de Merbel, Nico C ; Gansevoort, Ron T. ; Heerspink, Hiddo J L ; Mohamed, Abdulfataah A.A. ; Mohamed, Abdulfataah A A ; van de Merbel, Nico C. ; Stevens, Jasper ; Heerspink, Hiddo J.L. ; Gansevoort, Ron T ; van Londen, Marco ; Walland, Peter

A novel liquid chromatography-tandem mass spectrometry method is described for the quantitative determination of the kidney function markers iothalamate and hippuran in human serum and urine. It is based on protein precipitation with methanol followed by dilution of the supernatant for serum and simple dilution for urine. The polar analytes are chromatographically separated by a 6.5-min gradient on a low-ligand density reversed-phase column; detection is performed by electrospray ionization tandem mass spectrometry in the positive ion mode against stable-isotope labeled internal standards. The results of a thorough method validation show that iothalamate and hippuran can be simultaneously quantified in the concentration ranges 0.500-30.0 ng/mL and 10.0-5000 ng/mL for serum and urine, respectively, with values for CV and absolute bias not exceeding 10 %, and with sufficient stability in all relevant matrices and solvents. The method was successfully applied for the analysis of serum and urine samples of multiple individuals who received both iothalamate and hippuran.

100 Deals associated with Iothalamate Meglumine

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KEGG	Wiki	ATC	Drug Bank
D01999	Iothalamate Meglumine	V08AA04	DB09133

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10 top approved records.

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Indication	Country/Location	Organization	Date
Cerebrovascular Disorders	United States	Liebel-Flarsheim Co. LLC	16 Aug 1962
Contrast agents	United States	Liebel-Flarsheim Co. LLC	16 Aug 1962
Peripheral Arterial Disease	United States	Liebel-Flarsheim Co. LLC	16 Aug 1962
Urethral Diseases	United States	Liebel-Flarsheim Co. LLC	16 Aug 1962

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