Imaging procedures such as 1-(2-[18F]FLUOROETHYL)-L-Tryptophan PET/CT in patients with cancers may help doctors assess a patient's response to treatment and help plan the best treatment in the future. The purpose is to see if there can be a better differentiation of tumor and non-tumor tissue where the tumor tissue has a higher uptake of Tryptophan.

Start Date29 Sep 2022

Sponsor / Collaborator

Barbara Ann Karmanos Cancer Institute

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100 Clinical Results associated with 1-(2-[18F]FLUOROETHYL)-L-Tryptophan

100 Translational Medicine associated with 1-(2-[18F]FLUOROETHYL)-L-Tryptophan

100 Patents (Medical) associated with 1-(2-[18F]FLUOROETHYL)-L-Tryptophan

Literatures (Medical) associated with 1-(2-[18F]FLUOROETHYL)-L-Tryptophan

01 Feb 2017·Journal of Nuclear MedicineQ1 · MEDICINE

Assessment of Tryptophan Uptake and Kinetics Using 1-(2-¹⁸F-Fluoroethyl)-l-Tryptophan and α-¹¹C-Methyl-l-Tryptophan PET Imaging in Mice Implanted with Patient-Derived Brain Tumor Xenografts

Q1 · MEDICINE

Article

Author: Xin, Yangchun ; Michelhaugh, Sharon K ; Mangner, Thomas J ; Cai, Hancheng ; Juhász, Csaba ; Klinger, Neil V ; Guastella, Anthony R ; Zhang, Shaohui ; Muzik, Otto ; Polin, Lisa A ; Mittal, Sandeep

Abnormal tryptophan metabolism via the kynurenine pathway is involved in the pathophysiology of a variety of human diseases including cancers. α-¹¹C-methyl-l-tryptophan (¹¹C-AMT) PET imaging demonstrated increased tryptophan uptake and trapping in epileptic foci and brain tumors, but the short half-life of ¹¹C limits its widespread clinical application. Recent in vitro studies suggested that the novel radiotracer 1-(2-¹⁸F-fluoroethyl)-l-tryptophan (¹⁸F-FETrp) may be useful to assess tryptophan metabolism via the kynurenine pathway. In this study, we tested in vivo organ and tumor uptake and kinetics of ¹⁸F-FETrp in patient-derived xenograft mouse models and compared them with ¹¹C-AMT uptake.METHODSXenograft mouse models of glioblastoma and metastatic brain tumors (from lung and breast cancer) were developed by subcutaneous implantation of patient tumor fragments. Dynamic PET scans with ¹⁸F-FETrp and ¹¹C-AMT were obtained for mice bearing human brain tumors 1-7 d apart. The biodistribution and tumoral SUVs for both tracers were compared.RESULTS¹⁸F-FETrp showed prominent uptake in the pancreas and no bone uptake, whereas ¹¹C-AMT showed higher uptake in the kidneys. Both tracers showed uptake in the xenograft tumors, with a plateau of approximately 30 min after injection; however, ¹⁸F-FETrp showed higher tumoral SUV than ¹¹C-AMT in all 3 tumor types tested. The radiation dosimetry for ¹⁸F-FETrp determined from the mouse data compared favorably with the clinical ¹⁸F-FDG PET tracer.CONCLUSION¹⁸F-FETrp tumoral uptake, biodistribution, and radiation dosimetry data provide strong preclinical evidence that this new radiotracer warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abnormal tryptophan metabolism in human tumors.

100 Deals associated with 1-(2-[18F]FLUOROETHYL)-L-Tryptophan

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Indication	Highest Phase	Country/Location	Organization	Date
Apudoma	Phase 1	United States	Barbara Ann Karmanos Cancer Institute	29 Sep 2022
Brain metastases	Phase 1	United States	Barbara Ann Karmanos Cancer Institute	29 Sep 2022
Breast Cancer	Phase 1	United States	Barbara Ann Karmanos Cancer Institute	29 Sep 2022
Glioma	Phase 1	United States	Barbara Ann Karmanos Cancer Institute	29 Sep 2022
Rectal Cancer	Phase 1	United States	Barbara Ann Karmanos Cancer Institute	29 Sep 2022

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