Modified Danggui-Shaoyao Pills combined with Tai Chi for Depression with kidney deficiency and liver-qi stagnation in Chronic Kidney Disease: a randomized controlled, multi-center, clinical study.

Start Date01 Jun 2021

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100 Clinical Results associated with Danggui Shaoyao Granules

100 Translational Medicine associated with Danggui Shaoyao Granules

100 Patents (Medical) associated with Danggui Shaoyao Granules

Literatures (Medical) associated with Danggui Shaoyao Granules

01 Oct 2024·Journal of Ethnopharmacology

Tokishakuyakusan alleviates ultraviolet-induced skin pigmentation by decreasing the expression of melanogenesis-related enzymes

Article

Author: Sakai, Hiroyasu ; Ikarashi, Nobutomo ; Kon, Risako ; Saito, Rinka ; Nishinaka, Yui ; Tabata, Keito ; Hosoe, Tomoo ; Shinozaki, Yui ; Yokoyama, Koki

ETHNOPHARMACOLOGICAL RELEVANCETokishakuyakusan (TSS), a traditional Kampo medicine, can effectively alleviate symptoms unique to women, such as menstrual pain and menopausal symptoms, and this effect is believed to be related to its ability to increase the secretion of female hormones. TSS is also believed to be effective against skin pigmentation. However, no studies have examined the effect of TSS on pigmentation.AIM OF THE STUDYIn this study, we conducted basic research to determine the effects of TSS on pigmentation.MATERIALS AND METHODSFemale HRM-2 mice were given free access to a normal diet or a TSS-containing diet for 7 weeks. For 3 weeks starting from the 4th week of treatment, the back of the skin was irradiated with ultraviolet (UV) light, and the melanin level was measured. The expression levels of melanogenesis-related genes and inflammatory markers in the skin were analyzed.RESULTSThe melanin level in the skin of the mice exposed to UV radiation was approximately three times greater than that in the skin of the mice in the non-UV-irradiated group, confirming pigmentation due to UV irradiation. The protein expression levels of tyrosinase (Tyr), tyrosinase-related protein-1 (Tyrp1), and dopachrome tautomerase (Dct), which are important for melanin production, were significantly greater in the UV irradiation group than in the non-UV irradiation group. In contrast, the amount of skin melanin in the mice treated with TSS was significantly lower than that in the UV-irradiated group, and the expression levels of melanogenesis-related enzymes were also lower. Furthermore, TSS significantly decreased the expression of microphthalmia transcription factor (Mitf), a transcription factor for melanogenesis-related enzymes, and the inflammatory cytokines interleukin-1β and interleukin-6.CONCLUSIONSTSS inhibits melanin production in melanocytes by suppressing the increase in the expression of melanogenesis-related enzymes caused by UV irradiation. These findings suggested that this effect of TSS is exerted through the combined regulation of MITF expression and anti-inflammatory responses.

01 Sep 2024·Journal of Ethnopharmacology

Danggui-Shaoyao San alleviates cognitive impairment via enhancing HIF-1α/EPO axis in vascular dementia rats

Article

Author: Yue, Su ; Yafeng, Zhang ; Xiang, Li ; Ying, Xu ; Ningning, Yuan ; Xiaolan, Cheng ; Ruoyu, Jiang ; Junjie, Ma ; Zhongda, Wang ; Weiwei, Tao ; Hanwen, Shi

ETHNOPHARMACOLOGICAL RELEVANCEInvigorating blood circulation to remove blood stasis is a primary strategy in TCM for treating vascular dementia (VaD). Danggui-Shaoyao San (DSS), as a traditional prescription for neuroprotective activity, has been proved to be effective in VaD treatment. However, its precise molecular mechanisms remain incompletely understood.AIM OF THE STUDYThe specific mechanism underlying the therapeutic effects of DSS on VaD was explored by employing network pharmacology as well as in vivo and in viro experiment validation.MATERIALS AND METHODSWe downloaded components of DSS from the BATMAN-TCM database for target prediction. The intersection between the components of DSS and targets, PPI network, as well as GO and KEGG enrichment analysis were then performed. Subsequently, the potential mechanism of DSS predicted by network pharmacology was assessed and validated through VaD rat model induced by 2VO operation and CoCl₂-treated PC12 cells. Briefly, the DSS extract were first quantified by HPLC. Secondly, the effect of DSS on VaD was studied using MWM test, HE staining and TUNEL assay. Finally, the molecular mechanism of DSS against VaD was validated by Western blot and RT-QPCR experiments.RESULTSThrough network analysis, 137 active ingredients were obtained from DSS, and 67 potential targets associated with DSS and VaD were identified. GO and KEGG analysis indicated that the action of DSS on VaD primarily involves hypoxic terms and HIF-1 pathway. In vivo validation, cognitive impairment and neuron mortality were markedly ameliorated by DSS. Additionally, DSS significantly reduced the expression of proteins related to synaptic plasticity and neuron apoptosis including PSD-95, SYP, Caspase-3 and BCL-2. Mechanistically, we confirmed DSS positively modulated the expression of HIF-1α and its downstream proteins including EPO, p-EPOR, STAT5, EPOR, and AKT1 in the hippocampus of VaD rats as well as CoCl₂-induced PC12 cells. HIF-1 inhibitor YC-1 significantly diminished the protection of DSS on CoCl₂-induced PC12 cell damage, with decreased HIF-1α, EPO, EPOR expression.CONCLUSIONOur results initially demonstrated DSS could exert neuroprotective effects in VaD. The pharmacological mechanism of DSS may be related to its positive regulation on HIF-1α/EPO pathway.

01 Feb 2024·Auris Nasus Larynx

Efficacy of tokishakuyakusan and mecobalamin on post-infectious olfactory dysfunction: A prospective multicenter study

Article

Author: Kashiwagi, Takashi ; Suzuki, Motohiko ; Shikina, Takashi ; Akazawa, Hitoshi ; Okutani, Fumino ; Ueno, Takayoshi ; Hayama, Masaki ; Mori, Eri ; Matsuwaki, Yoshinori ; Shiga, Hideaki ; Kondo, Kenji ; Kobayashi, Masayoshi ; Miwa, Takaki ; Ikeda, Katsuhisa ; Ogino, Eriko ; Tsuzuki, Kenzo ; Hyo, Yukiyoshi ; Shibata, Minori ; Nakamura, Yosuke

OBJECTIVETo determine if tokishakuyakusan (TSS) is effective for treating post-infectious olfactory dysfunction (PIOD) compared with vitamin B₁₂ (mecobalamin).METHODSWe conducted a randomized, nonblinded clinical trial. Patients with PIOD enrolled in 17 hospitals and clinics from 2016 to 2020 were randomly divided into two groups, and we administered TSS or mecobalamin for 24 weeks. Their olfactory function was examined using interviews and T&T olfactometry. The improvement of olfactory dysfunction was assessed following the criteria of the Japanese Rhinologic Society.RESULTSOverall, 82 patients with PIOD were enrolled in this study. In the TSS and mecobalamin groups, 39 patients completed the medication regimen. In the TSS and mecobalamin groups, olfactory dysfunction was significantly improved based on self-reports and olfactory test results. The improvement rate of olfactory dysfunction was 56% in the TSS group and 59% in the mecobalamin group. Early intervention within 3 months produced a better prognosis than the treatment initiated after 4 months. Furthermore, age and sex differences were not observed. Both medications produced no severe adverse events.CONCLUSIONThe present study showed that TSS and mecobalamin might be useful for treating PIOD.

100 Deals associated with Danggui Shaoyao Granules

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Indication	Country/Location	Organization	Date
Headache	JP	Ohsugi Pharmaceutical Co., Ltd.	25 Dec 1986
Low Back Pain	JP	Ohsugi Pharmaceutical Co., Ltd.	25 Dec 1986
Back Pain	JP	Kowa Yakutsu Y.K.	02 Sep 1986
Chilblains	JP	Kowa Yakutsu Y.K.	02 Sep 1986
Dizziness	JP	Kowa Yakutsu Y.K.	02 Sep 1986
Tumescence	JP	Kowa Yakutsu Y.K.	02 Sep 1986
Abortion	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Andropause	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Anemia	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Common Cold	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Endometritis	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Hemorrhoids	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Infertility	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Menstruation Disturbances	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986
Nephrosis	JP	Sanwa Shoyaku Co., Ltd.	18 Jul 1986

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