Nabumetone

In this paper, we have developed an efficient Ni-catalyzed highly regioselective and stereoselective hydrocyanation of alkynes and Zn(CN)₂.By the control of different ligands, nickel-catalyzed regiodivergent hydrocyanation of terminal alkynes to linear and branched vinyl nitriles via anti-Markovnikov and Markovnikov additions was achieved.In addition, in this system, water or alc. served as the hydrogen source, thus avoiding the in-situ generation of hydrogen cyanide in the reaction.A preliminary study of the mechanism was performed by deuterium labeling experiments and several control experiments

A novel dispersive magnetic micro-solid-phase extraction (DM-μ-SPE) method based on the magnetic NiFe2O4 polyamidoamine dendrimers modified with deep eutectic solvent sorbent has been developed for the extraction of naproxen and nabumetone.The extracted analytes were quantified by a high-performance liquid chromatog. (HPLC) method with UV detection at 280 nm.The linearity was in the range of 1-400 μg L-1 for naproxen and 3-400 μg L-1 for nabumetone.The developed DM-μ-SPE/HPLC-UV method has been characterized by excellent intra- and inter-day repeatability of 2.3, 3.3, and 2.5, 4.0%, resp., for naproxen and nabumetone at the concentration level of 70.0 μg L-1 (n = 5).Enhancement factors of 157.7 and 151.8 and limit of detections of 0.15 μg L-1 and 0.26 μg L-1 for naproxen and nabumetone were achieved, resp.The sorption isotherm study illustrated that the exptl. data of NAP fitted better to the Langmuir isotherm with a maximum monolayer sorption capacity of 76.92 mg g-1, while the NAB data fitted to the Temkin isotherm model.The method was successfully applied to the determination of non-steroidal anti-inflammatory drug analytes in water and milk samples.