Solar disinfection (SODIS) is regarded as an affordable and effective point-of-use (POU) water disinfection treatment urgently needed in rural developing world. This work developed an enhanced SODIS scheme that utilized a novel flower pollen-based catalyst (Te-TRP). The bench-scale experiments demonstrated 100% photothermocatalytic inactivation of approximately 7-log E. coli K-12, Spingopyxis sp. BM1-1, or S. aureus bacterium by Te-TRP within 40-60 min. Moving toward practical device design, we constructed a flow-through reactor and demonstrated the outstanding water disinfection performance of Te-TRP. The in-depth mechanistic study revealed the synergetic effect between photocatalysis and photothermal conversion and identified the bacterial inactivation pathway. ¹O₂ and ·O₂^¯ were verified to be the dominant reactive oxygen species involved in the bacterial inactivation. The damage to bacterial cells caused by photothermocatalytic reactions was systematically investigated, demonstrating the cell membrane destruction, the loss of enzyme activity, the increased cell membrane permeability, and the complete inactivation of bacteria without the viable but nonculturable state cells. This work not only affords a facile approach to preparing biomaterial-based catalysts capable of efficient photothermocatalytic bacterial inactivation, but also proposes a prototype of POU water treatment, opening up an avenue for sustainable environmental remediation.

01 Jul 2021·EsophagusQ3 · MEDICINE

Comparison of the outcomes between total eversion and conventional triangulating stapling technique in cervical esophagogastric anastomosis after esophagectomy: a propensity score-matched analysis

Q3 · MEDICINE

Article

Author: Kanamori, Jun ; Ushida, Yuta ; Toihata, Tasuku ; Otake, Reiko ; Takahashi, Keita ; Mine, Shinji ; Okamura, Akihiko ; Kozuki, Ryotaro ; Kanie, Yasukazu ; Watanabe, Masayuki ; Imamura, Yu

BACKGROUNDAnastomotic leakage and stenosis remain major problems after esophageal reconstruction. This study evaluated the clinical outcomes between the total eversion (TE) triangulating stapling technique (TST) and conventional (C) TST.METHODSThe study included 404 consecutive patients with esophageal cancer who underwent cervical esophagogastrostomy by TST between January 2013 and December 2018. The postoperative outcomes were compared between TE-TST and C-TST using propensity score-matched analysis.RESULTSBefore matching, the cT stage and the cTNM stage were different between the groups. After matching, each group consisted of 128 patients. The patients' background characteristics were similar between the groups. Although the incidence of anastomotic leakage was similar between the groups (p = 0.216), anastomotic stricture occurred in 19 (14.8%) and 7 (5.5%) patients in the C-TST and the TE-TST groups, respectively (p = 0.021).CONCLUSIONSThe incidence of anastomotic stenosis was significantly lower in the TE-TST group than in the C-TST group. TE-TST decreases the incidence of anastomotic stricture and can improve the quality of life in patients undergoing esophagectomy.

01 Mar 2019·Bioresource TechnologyQ1 · ENGINEERING & TECHNOLOGY

ADM1 based mathematical model of trace element complexation in anaerobic digestion processes

Q1 · ENGINEERING & TECHNOLOGY

Article

Author: Maria Rosaria Mattei ; Eric D. van Hullebusch ; Bikash Chandra Maharaj ; Giovanni Esposito ; Luigi Frunzo

In this study, a new model based on anaerobic digestion model no.1 (ADM1) approach has been proposed to simulate trace elements (TEs) complexation, precipitation and their effect on the anaerobic batch methane production. TEs complexation reactions with VFAs and EDTA have been incorporated in an extended ADM1 model which considers TE precipitation/dissolution reactions as well as biodegradation processes. The kinetic model tracks the dynamics of 90 state variables which constitute the components of the proposed anaerobic digestion (AD) model. The incorporation of the complexation reactions required the definition of new inorganic components (EDTA species) and new complexation process rates in the ADM1 framework. The charge balance was modified accordingly to consider the effects of the additional components. The new model is able to predict: a) the effect of TE-EDTA/VFA complexation on methane production, and b) the effect of the initial calcium and magnesium concentrations on process performance.

100 Deals associated with TED-N

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Spinal Cord Injuries	Phase 2	KR	S.Biomedics Co., Ltd.	16 Aug 2022

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

TED-N

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation