Last update 01 Nov 2024

Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

Last update 01 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Monoclonal antibody

Synonyms-

Target

HIV envelope protein gp120 x gp41

Mechanism

HIV envelope protein gp120 inhibitors, gp41 inhibitors(Transmembrane glycoprotein gp41 inhibitors)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesUrogenital Diseases

Active Indication

HIV Infections

Inactive Indication-

Originator Organization

Polymun Scientific Immunbiologische Forschung GmbH

Active Organization

Polymun Scientific Immunbiologische Forschung GmbH

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

100 Clinical Results associated with Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

100 Translational Medicine associated with Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

100 Patents (Medical) associated with Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

485

Literatures (Medical) associated with Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

16 Apr 2024·Journal of Virology

Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies

Article

Author: Schommers, Philipp ; Weil, Tatjana ; Wettstein, Lukas ; von Maltitz, Pascal ; Münch, Jan ; Klein, Florian

ABSTRACTTopically applied microbicides may play a critical role in preventing sexual transmission of human immunodeficiency virus type 1 (HIV-1); however, their efficacy can be compromised by amyloid fibrils present in semen, which significantly increase HIV-1 infectivity. This phenomenon may have contributed to the failure of most microbicide candidates in clinical settings. Understanding the impact of semen on microbicide effectiveness is thus crucial. In our study, we evaluated the influence of semen on the neutralizing activity of broadly neutralizing antibodies (bNAbs), including PG16, PGT121, 10–1074, 3BNC117, and VRC01, which are potential microbicide candidates. We found that semen enhances infection of HIV-1 transmitted/founder viruses but only marginally affects the neutralizing activity of tested antibodies, suggesting their potential for microbicide application. Our findings underscore the need to consider semen-mediated enhancement when evaluating and developing microbicides and highlight the potential of incorporating HIV-1 bNAbs in formulations to enhance efficacy and mitigate HIV-1 transmission during sexual encounters.IMPORTANCEThis study examined the impact of semen on the development of microbicides, substances used to prevent the transmission of HIV-1 during sexual activity. Semen contains certain components that can render the virus more infectious, posing a challenge to microbicide effectiveness. Researchers specifically investigated the effect of semen on a group of powerful antibodies called broadly neutralizing antibodies, which can neutralize a large spectrum of different HIV-1 variants. The results revealed that semen only had a minimal effect on the antibodies' ability to neutralize the virus. This is promising because it suggests that these antibodies could still be effective in microbicides, even in the presence of semen. Understanding this interaction is crucial for developing better strategies to prevent HIV-1 transmission. By incorporating the knowledge gained from this study, scientists can now focus on creating microbicides that consider the impact of semen, bringing us closer to more effective prevention methods.

01 Jan 2023·Open access journal of contraception

A Brief History and Advancement of Contraceptive Multipurpose Prevention Technology (cMPT) Products.

Review

Author: Politch, Joseph A ; Anderson, Deborah J ; Barmine, Jessica H ; Dohadwala, Sarah

The high incidence of HIV and other sexually transmitted infections (STIs), and an unmet need for modern contraception resulting in a high unintended pregnancy rate, are major problems in reproductive health. The concept of multipurpose prevention technology (MPT) was introduced following the failure of several leading microbicide candidates to prevent human immunodeficiency virus type 1 (HIV-1) transmission in large clinical trials in the early 2000s. MPTs are defined as products designed to simultaneously prevent at least two of the following conditions: unintended pregnancy, HIV-1, or other major STIs. The goal of contraceptive MPT products (cMPTs) is to provide contraception and protection against one or more major STI pathogen (eg, HIV-1, herpes simplex virus (HSV) type 2, Neisseria gonorrhoeae (gonorrhea), Treponema pallidum (syphilis), Trichomonas vaginalis, Chlamydia trachomatis (Chlamydia). This new field has great potential and will benefit from lessons learned from the early microbicide trials. The cMPT field includes candidates representing various categories with different mechanisms of action including pH modifiers, polyions, microbicidal peptides, monoclonal antibodies, and other peptides that target specific reproductive and infectious processes. More preclinical research is being conducted to ensure minimal side effects and maximum efficacy in vivo. Effective proven and novel candidates are being combined to maximize efficacy, minimize side effects, and avoid drug resistance. More attention is being paid to acceptability and new delivery systems. cMPTs have a very promising future if adequate resources can be mobilized to sustain the effort from preclinical research to clinical trials to bring effective, acceptable, and affordable products to market.

02 Oct 2022·African Journal of AIDS Research

Understanding the role of men in women's use of the vaginal ring and oral PrEP during pregnancy and breastfeeding: multi-stakeholder perspectives

Article

Author: Macagna, Nicole ; Hartmann, Miriam ; Piper, Jeanna ; Mutero, Prisca ; Reddy, Krishnaveni ; van der Straten, Ariane ; Musara, Petina ; Taulo, Frank ; Ggita, Joseph ; Mgodi, Nyaradzo M ; Ryan, Julia H

We examined men's influence on women's interest in biomedical HIV prevention during pregnancy and breastfeeding through structured questionnaires and focus group discussions with currently or recently pregnant and breastfeeding (P/BF) women (n = 65), men with P/BF partners (n = 63) and mothers/mothers-in-law of P/BF women (n = 68) in eastern and southern Africa. Data were transcribed, coded and summarised into analytical memos. Men were depicted by most participants as joint decision-makers and influencers of women's use of HIV prevention. Cultural and religious norms depicting men as heads, breadwinners and protectors of the family were cited to legitimise their involvement in decision-making. Male partner education and engagement were recommended to garner their support in women's HIV prevention. This study elucidates how P/BF women's ability to prevent HIV is shaped by traditional and contemporary gender norms in social settings and locations where the study was conducted. Findings may aid intervention design to engage men for P/BF women's effective use of microbicide and oral PrEP.

100 Deals associated with Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
HIV Infections	Phase 1	-	Polymun Scientific Immunbiologische Forschung GmbH	-

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


IAS2004	Not Applicable	HIV Infections	194	microbicide (HIV-discordant couples)	edfxupcdlk(ausxwcbpen) = pwrmqwjsyh xglcxqqcxl (nonnasljeb )	-	01 Jan 2004

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Microbicide monoclonal antibody triple combination(Polymun Scientific Immunbiologische Forschung GmbH)

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